Anti-STING1/TMEM173 Antibody (R2J01)

Catalog No.

RHJ16702

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

FCM: 1:20-1:100, IF: 1:50-1:200, WB: 1:1000-1:2000

Target

STING1, Stimulator of interferon genes protein, Endoplasmic reticulum interferon stimulator, Transmembrane protein 173, ERIS, hSTING, TMEM173, Mediator of IRF3 activation, MITA, hMITA

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q86WV6

Applications

FCM, IF, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R2J01

A guide to selecting high-performing antibodies for STING1 (Uniprot ID: Q86WV6) for use in western blot, immunoprecipitation, and immunofluorescence., PMID:40535171

Identification of a Novel Small Molecule STING Agonist Reshaping the Immunomicroenvironment of Pancreatic Ductal Adenocarcinoma., PMID:40520004

A Multi-Threshold Micelle Improves Tumor Accumulation and STING Immunotherapy., PMID:40439216

Nanoimmunomodulation of the Aβ-STING feedback machinery in microglia for Alzheimer's disease treatment., PMID:40434641

Reprogramming tumor-associated macrophages using STING or TLR agonists: a promising strategy to enhance immunotherapy in hormone-dependent cancers., PMID:40379270

[Buzhong Yiqi Decoction alleviates immune injury of autoimmune thyroiditis in NOD.H-2~(h4)mice via c GAS-STING signaling pathway]., PMID:40350879

Microbial dysbiosis fuels STING-driven autoinflammation through cyclic dinucleotides., PMID:40334619

The emerging concept of ANCA-associated vasculitis related to inborn errors of immunity., PMID:40294837

[Effects of lipopolysaccharide-activated interferon gene stimulator signaling on periodontal ligament cells]., PMID:40268534

STING agonist-based ER-targeting molecules boost antigen cross-presentation., PMID:40140567

Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy., PMID:40128784

Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy., PMID:40098909

Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1., PMID:40083918

PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion., PMID:40048154

ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion., PMID:40033100

XMT-2056, a HER2-Directed STING Agonist Antibody-Drug Conjugate, Induces Innate Antitumor Immune Responses by Acting on Cancer Cells and Tumor-Resident Immune Cells., PMID:40029253

STING activation improves T-cell-engaging immunotherapy for acute myeloid leukemia., PMID:40009483

Sustained Interferon Signature Suppression With Anifrolumab in a Patient With STING-Associated Vasculopathy with Onset in Infancy Refractory to JAK Inhibitor and Dazukibart Therapy., PMID:40007227

TAX1BP1-dependent autophagic degradation of STING1 impairs anti-tumor immunity., PMID:40000606

Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy., PMID:39994712

Inhibitors of soluble epoxide hydrolase and cGAS/STING repair defects in amyloid-β clearance underlying vascular complications of Alzheimer's disease., PMID:39962970

STING activation and overcoming the challenges associated with STING agonists using ADC (antibody-drug conjugate) and other delivery systems., PMID:39922441

Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody-Drug Conjugate TAK-500., PMID:39918395

Chemotherapy boosts anti-angiogenic and anti-PD-1 combination therapy through activation of cCAS-STING pathway in colon cancer., PMID:39904029

Immune checkpoint inhibitors mediate myocarditis by promoting macrophage polarization via cGAS/STING pathway., PMID:39884185

Intratumoral or Subcutaneous MK-2118, a Noncyclic Dinucleotide STING Agonist, with or without Pembrolizumab, for Advanced or Metastatic Solid Tumors or Lymphomas., PMID:39846804

Activating the cGAS-STING Pathway by Manganese-Based Nanoparticles Combined with Platinum-Based Nanoparticles for Enhanced Ovarian Cancer Immunotherapy., PMID:39846241

Open-label, phase Ia study of STING agonist BI 1703880 plus ezabenlimab for patients with advanced solid tumors., PMID:39817655

Personalized Nanovaccine Based on STING-Activating Nanocarrier for Robust Cancer Immunotherapy., PMID:39817337

STING Agonist VB-85247 Induces Durable Antitumor Immune Responses by Intravesical Administration in a Non-Muscle-Invasive Bladder Cancer., PMID:39700406

Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma., PMID:39658648

Role of STING Deficiency in Amelioration of Mouse Models of Lupus and Atherosclerosis., PMID:39605244

Urease-powered nanomotor containing STING agonist for bladder cancer immunotherapy., PMID:39548120

Bendamustine-rituximab elicits dual tumoricidal and immunomodulatory responses via cGAS-STING activation in diffuse large B-cell lymphoma., PMID:39521616

Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy., PMID:39464890

Targeting STING signaling for the optimal cancer immunotherapy., PMID:39450170

Immunomodulatory effects of trastuzumab deruxtecan through the cGAS-STING pathway in gastric cancer cells., PMID:39449023

Robust and Sustained STING Pathway Activation via Hydrogel-Based In Situ Vaccination for Cancer Immunotherapy., PMID:39405469

Intratumoral STING agonist reverses immune evasion in PD-(L)1-refractory Merkel cell carcinoma: mechanistic insights from detailed biomarker analyses., PMID:39401968

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model., PMID:39353433

DKN-01 Suppresses Gastric Cancer Progression Through Activating cGAS-STING Pathway to Block Macrophage M2 Polarization., PMID:39352454

Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway., PMID:39237260

Cannabidiol Enhances Atezolizumab Efficacy by Upregulating PD-L1 Expression via the cGAS-STING Pathway in Triple-Negative Breast Cancer Cells., PMID:39226389

Microglial cGAS-STING signaling underlies glaucoma pathogenesis., PMID:39190350

Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS-STING activation for hepatocellular carcinoma chemo-immunotherapy., PMID:39180916

Metal-Phenolic Vehicles Potentiate Cycle-Cascade Activation of Pyroptosis and cGAS-STING Pathway for Tumor Immunotherapy., PMID:39155444

Overcome the challenge for intratumoral injection of STING agonist for pancreatic cancer by systemic administration., PMID:39113096

Circulating cell-free DNA promotes inflammation in dermatomyositis patients with anti-NXP2 antibodies  via the cGAS/STING pathway., PMID:39110532

Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy., PMID:39060021

Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer., PMID:39059614

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