Catalog No.
RHH39601
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IP: 1:20, WB: 1:500-1:1000
Target
Renal carcinoma antigen NY-REN-56, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, iPFK-2, PFKFB3, 6PF-2-K/Fru-2,6-P2ase 3, PFK/FBPase 3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16875
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2H60
Glycolytic PFKFB3 and Glycogenic UGP2 Axis Regulates Perfusion Recovery in Experimental Hind Limb Ischemia., PMID:38934117
Identifying hub genes in response to ustekinumab and the impact of ustekinumab treatment on fibrosis in Crohn's disease., PMID:38840917
Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming., PMID:38045056
Assessing the Immune Cell Subset and Genetic Mutations in Patients With Palindromic Rheumatism Seronegative for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide., PMID:35819819
Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation., PMID:35637411
A low-carbohydrate diet containing soy protein and fish oil reduces breast but not prostate cancer in C3(1)/Tag mice., PMID:34958345
The Role of HIF1α-PFKFB3 Pathway in Diabetic Retinopathy., PMID:34019671
Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes., PMID:33310262
Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions., PMID:33256735
Effects of NRP1 on angiogenesis and vascular maturity in endothelial cells are dependent on the expression of SEMA4D., PMID:32945351
Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI., PMID:32641990
MIF signaling blocking alleviates airway inflammation and airway epithelial barrier disruption in a HDM-induced asthma model., PMID:31708110
The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses., PMID:30171427
Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid., PMID:30170611
Detecting and Imaging O-GlcNAc Sites Using Glycosyltransferases: A Systematic Approach to Study O-GlcNAc., PMID:30100348
Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells., PMID:28152500
A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22., PMID:27777982
Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort., PMID:27015091
Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer., PMID:26530697
Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway., PMID:22811469
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation., PMID:22591674
Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer., PMID:16115917
For research use only. Not for human or drug use.
