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Anti-ITPR1 Antibody (R2F62)

Catalog #:   RHG85301 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IHC, IP, WB
Accession: Q14643
Overview

Catalog No.

RHG85301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000

Target

Inositol 1,4,5-trisphosphate receptor type 1, INSP3R1, IP3R 1, ITPR1, InsP3R1, Type 1 InsP3 receptor, Type 1 inositol 1,4,5-trisphosphate receptor, IP3 receptor isoform 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q14643

Applications

IHC, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R2F62

Data Image
  • Western blot
    Western blot analysis of IP3 Receptor expression in HeLa cell lysate.
References

Chronic vertigo and central oculomotor dysfunction with evidence of anti-ITPR1 antibodies., PMID:39891750

Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria., PMID:39708293

Impact of anti-PD-1 therapy in a melanoma patient with paraneoplastic anti-ITPR1 encephalitis., PMID:38061970

Autoantibodies against Central Nervous System Antigens and the Serum Levels of IL-32 in Patients with Schizophrenia., PMID:36122562

Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature., PMID:35907972

Paraneoplastic encephalomyeloradiculits with multiple autoantibodies against ITPR-1, GFAP and MOG: case report and literature review., PMID:34635185

Neurological Autoimmunity Associated With Homer-3 Antibody: A Case Series From China., PMID:34580182

Confabulation, amnesia and motor memory loss as a presentation of apparent ITPR1 antibody autoimmune encephalitis., PMID:34531236

Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia., PMID:34489848

Purkinje cell (PC) antibody positivity in a patient with autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy., PMID:33287611

Neurochondrin Antibody Serum Positivity in Three Cases of Autoimmune Cerebellar Ataxia., PMID:31179511

Paraneoplastic cerebellar degeneration associated with anti-ITPR1 antibodies., PMID:28203616

Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells., PMID:28191598

Selaginella uncinata flavonoids ameliorated ovalbumin-induced airway inflammation in a rat model of asthma., PMID:27916586

Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy., PMID:27776522

Sulforaphane-induced apoptosis involves the type 1 IP3 receptor., PMID:27528021

Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case., PMID:26869529

'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII., PMID:26377085

Generation and application of a novel InsP(3)R(1) mono-antibody from mouse., PMID:25522905

Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia., PMID:25498830

Tumor necrosis factor-alpha-induced reduction of glomerular filtration rate in rats with fulminant hepatic failure., PMID:24887412

Interleukin-6 prevents NMDA-induced neuronal death via Gp130 signaling-dependent IP3R inhibition., PMID:24378454

Nuclear ALG-2 protein interacts with Ca2+ homeostasis endoplasmic reticulum protein (CHERP) Ca2+-dependently and participates in regulation of alternative splicing of inositol trisphosphate receptor type 1 (IP3R1) pre-mRNA., PMID:24078636

Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder., PMID:23697635

Activated inositol 1,4,5-trisphosphate receptors are modified by homogeneous Lys-48- and Lys-63-linked ubiquitin chains, but only Lys-48-linked chains are required for degradation., PMID:21071436

Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells., PMID:20713546

c-Myb-dependent inositol 1,4,5-trisphosphate receptor type-1 expression in vascular smooth muscle cells., PMID:17363689

Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores., PMID:16870612

Calcium signaling pathways mediating synaptic potentiation triggered by amyotrophic lateral sclerosis IgG in motor nerve terminals., PMID:16525045

A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets., PMID:16308346

Jak2 tyrosine kinase prevents angiotensin II-mediated inositol 1,4,5 trisphosphate receptor degradation., PMID:16257270

The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria., PMID:16192275

Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor., PMID:16183993

Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein., PMID:15901789

Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells., PMID:15728185

Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor., PMID:15308649

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate., PMID:15263017

Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353., PMID:14761954

Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation., PMID:14662757

Inositol 1,4,5-trisphosphate receptor (type 1) phosphorylation and modulation by Cdc2., PMID:14635192

Modification of phospholipase C-gamma-induced Ca2+ signal generation by 2-aminoethoxydiphenyl borate., PMID:14558886

Type-specific inositol 1,4,5-trisphosphate receptor localization in the vomeronasal organ and its interaction with a transient receptor potential channel, TRPC2., PMID:12472899

Calcium-binding proteins and calcium-release channels in human maturing oocytes, pronuclear zygotes and early preimplantation embryos., PMID:12407053

Inositol 1,4,5-trisphosphate receptor function in human oocytes: calcium responses and oocyte activation-related phenomena induced by photolytic release of InsP(3) are blocked by a specific antibody to the type I receptor., PMID:12356940

Glycoprotein Ib cross-linking/ligation on echicetin-coated surfaces or echicetin-IgMkappa in stirred suspension activates platelets by cytoskeleton modulated calcium release., PMID:12324454

Endogenously expressed Trp1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets., PMID:12196544

PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells., PMID:11927609

BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor., PMID:11782428

Molecular characterization of the starfish inositol 1,4,5-trisphosphate receptor and its role during oocyte maturation and fertilization., PMID:11687583

Co-localization of the inositol 1,4,5-trisphosphate receptor and calreticulin in the equatorial segment and in membrane bounded vesicles in the cytoplasmic droplet of human spermatozoa., PMID:11574661

Datasheet

Document Download

Anti-ITPR1 Antibody (R2F62).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

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Anti-ITPR1 Antibody (R2F62) [RHG85301]
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