Catalog No.
YHC87201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu206
Predicted molecular weight
25.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11233
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ras-related protein Ral-A, RAL, RALA
RalB uncoupling from exocyst is required for endothelial Weibel-Palade body exocytosis., PMID:40172988
Novel De Novo RALA Missense Variants Expand the Genotype Spectrum of Hiatt-Neu-Cooper Neurodevelopmental Syndrome., PMID:39918382
Critical role for platelet Ral GTPases in regulating venous thrombosis in mice., PMID:39454881
HuR-miRNA complex activates RAS GTPase RalA to facilitate endosome targeting and extracellular export of miRNAs., PMID:38360271
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation., PMID:38286821
TORC1 regulation of dendrite regrowth after pruning is linked to actin and exocytosis., PMID:37167328
Regulation of Ras p21 and RalA GTPases activity by quinine in mammary epithelial cells., PMID:37131040
Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse model., PMID:36923939
Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma., PMID:36817861
Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module., PMID:36812304
Systematic pan-cancer analysis identifies RALA as a tumor targeting immune therapeutic and prognostic marker., PMID:36466919
FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer., PMID:36229838
The RalGAPα1-RalA signal module protects cardiac function through regulating calcium homeostasis., PMID:35879328
Brain Somatic Variant in Ras-Like Small GTPase RALA Causes Focal Cortical Dysplasia Type II., PMID:35846790
The RAL Enigma: Distinct Roles of RALA and RALB in Cancer., PMID:35626682
EGFR promotes the apoptosis of CD4+ T lymphocytes through TBK1/Glut1 induced Warburg effect in sepsis., PMID:35618635
RalGPS2 Interacts with Akt and PDK1 Promoting Tunneling Nanotubes Formation in Bladder Cancer and Kidney Cells Microenvironment., PMID:34944949
RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth., PMID:34944458
Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma., PMID:34767674
Presence of serum RalA and serum p53 autoantibodies in 1833 patients with various types of cancers., PMID:34632560
Shigella flexneri subverts host polarized exocytosis to enhance cell-to-cell spread., PMID:34608697
Formulating RALA/Au nanocomplexes to enhance nanoparticle internalisation efficiency, sensitising prostate tumour models to radiation treatment., PMID:34538237
Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs., PMID:34480001
RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal., PMID:34320341
The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer., PMID:34118960
RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis., PMID:34096503
Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma., PMID:34009715
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules., PMID:33632898
Possible predictive significance of serum RalA autoantibodies on relapse-free survival in patients with colorectal cancer., PMID:33363728
Design and Efficient Synthesis of RalA Inhibitors Containing the Dihydro-α-carboline Scaffold., PMID:33244883
Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing., PMID:32993972
Prevalence of autoantibodies against Ras-like GTPases, RalA, in patients with gastric cancer., PMID:32765875
Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex., PMID:31969325
A Crucial Role for the Small GTPase Rac1 Downstream of the Protein Kinase Akt2 in Insulin Signaling that Regulates Glucose Uptake in Mouse Adipocytes., PMID:31683681
Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair., PMID:31676385
Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experiments., PMID:31408780
Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression., PMID:31329042
Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system., PMID:31201267
RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation., PMID:31201266
RalA and RalB relocalization to depolarized mitochondria depends on clathrin-mediated endocytosis and facilitates TBK1 activation., PMID:30995277
Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets., PMID:30880223
RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes., PMID:30853556
Emerging RAS superfamily conditions involving GTPase function., PMID:30763311
RALA mutation in a patient with autism spectrum disorder and Noonan syndrome-like phenotype., PMID:30761613
Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle., PMID:30735546
De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay., PMID:30500825
Phospholipase D-dependent mTOR complex 1 (mTORC1) activation by glutamine., PMID:30194281
RalA controls glucose homeostasis by regulating glucose uptake in brown fat., PMID:29915037
Polymer Nanovesicle-Mediated Delivery of MLN8237 Preferentially Inhibits Aurora Kinase A To Target RalA and Anchorage-Independent Growth in Breast Cancer Cells., PMID:29863884
Subcellular localization of aquaporin 3 in prostate cancer is regulated by RalA., PMID:29532894
For research use only. Not for human or drug use.
