Catalog No.
RHG47901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:500-1:1000
Target
Cyclin-A/CDK2-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2, SKP2, p45skp2, FBXL1, F-box protein Skp2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13309
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2E22
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma., PMID:39609269
Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis., PMID:38130998
Comparative Analysis on Abnormal Methylome of Differentially Expressed Genes and Disease Pathways in the Immune Cells of RA and SLE., PMID:34079550
Prolonged cetuximab treatment promotes p27Kip1-mediated G1 arrest and autophagy in head and neck squamous cell carcinoma., PMID:33664437
Metformin and an insulin/IGF-1 receptor inhibitor are synergistic in blocking growth of triple-negative breast cancer., PMID:32940848
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2., PMID:32830536
The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFβ Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A., PMID:32774143
Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation., PMID:30885218
B Cell Development sans B Cell Receptor Responsiveness Due to Unfolded Protein Response-Triggered Mef2c Protein Degradation., PMID:30305329
Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence., PMID:28461484
Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist., PMID:28346424
Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin., PMID:28335434
Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors., PMID:26474281
Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells., PMID:26416244
Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFNγ-dependent cell-cycle arrest., PMID:25127875
Biologic correlates and significance of axonogenesis in prostate cancer., PMID:24767770
Knockdown of SCF(Skp2) function causes double-parked accumulation in the nucleus and DNA re-replication in Drosophila plasmatocytes., PMID:24205363
FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21(Waf1) and p27(Kip1)., PMID:23939995
Downregulation of Ezh2 methyltransferase by FOXP3: new insight of FOXP3 into chromatin remodeling?, PMID:23688634
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis., PMID:22632973
All-trans retinoic acid inhibits mesangial cell proliferation by up-regulating p21Waf1/Cip1 and p27Kip1 and down-regulating Skp2., PMID:22344541
P27/SKP-2 histochemical profile is relevant to malignant salivary gland tumors (MST) histogenesis and tumor grade., PMID:22094872
Up-regulation of Cks1 and Skp2 with TNFα/NF-κB signaling in chronic progressive nephropathy., PMID:22017545
Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro., PMID:21317921
[Prognostic significance of Skp2 and p27(kip) in diffuse large B cell lymphoma]., PMID:21258183
Inhibition of proliferation of rabbit lens epithelial cells by S-phase kinase-interacting protein 2 targeting small interfering RNA., PMID:20508867
Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors., PMID:20492666
In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms., PMID:20465575
Prognostic significance of S-phase kinase-associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: effects of rituximab., PMID:19889619
Inhibition of cell proliferation of Tenon's capsule fibroblast by S-phase kinase-interacting protein 2 targeting SiRNA through increasing p27 protein level., PMID:19875654
A relationship between p27(kip1) and Skp2 after adult brain injury: implications for glial proliferation., PMID:19852587
Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells., PMID:19625121
An in vivo study of Cdh1/APC in breast cancer formation., PMID:19350629
Array comparative genomic hybridization in retinoma and retinoblastoma tissues., PMID:19183342
Regulation of Sp1 by cell cycle related proteins., PMID:18769160
The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype., PMID:18620730
Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis., PMID:18535175
Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells., PMID:18074352
Forkhead protein FKHR and its phosphorylated form p-FKHR in human prostate cancer., PMID:17597184
Skp2 is an independent prognosticator of gallbladder carcinoma among p27(Kip1)-interacting cell cycle regulators: an immunohistochemical study of 62 cases by tissue microarray., PMID:17384652
Utility of SKP2 and MIB-1 in grading follicular lymphoma using quantitative imaging analysis., PMID:17350668
Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing., PMID:17308064
Increased expression of SKP2 and phospho-MAPK/ERK1/2 and decreased expression of p27 during tumor progression of cervical neoplasms., PMID:17079005
A peptide-based inhibitor for prevention of B cell hyperproliferation induced by Epstein-Barr virus., PMID:16876848
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway., PMID:16170383
Prognostic significance of p27Kip1, p45Skp2 and Ki67 expression profiles in Merkel cell carcinoma, extracutaneous small cell carcinoma, and cutaneous squamous cell carcinoma., PMID:15910592
The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma., PMID:15717322
Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship., PMID:15491322
Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2., PMID:15314162
Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma., PMID:15073847
For research use only. Not for human or drug use.
