Catalog No.
YHC85601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp534-Gly615
Predicted molecular weight
11.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11142
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lipopolysaccharide-associated protein 1, HSPA10, Heat shock 70 kDa protein 8, LPS-associated protein 1, LAP-1, HSP73, HSC70, HSPA8, Heat shock cognate 71 kDa protein
USP43-mediated HSPA8 deubiquitination alleviates diabetic kidney disease., PMID:40505547
Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer., PMID:40504349
Harnessing miRNA dynamics in HIV-1-infected macrophages: Unveiling new targeted therapeutics using systems biology., PMID:40453371
RNA sequencing and genome-wide association analysis reveal key genes responsible for different feather colors in Youjiang goose., PMID:40424883
Small Extracellular Vesicles Orchestrate Cisplatin-Induced Ototoxicity: Potential Biomarker and Targets Discovery., PMID:40411396
Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer., PMID:40395325
Quantitative Proteome Analysis of Plasma Extracellular Vesicles Identifies Three Proteins with Potential Diagnostic Value for Mycobacterium bovis Infection in Cows., PMID:40372928
Chaperone-mediated autophagy manipulates PGC1α stability and governs energy metabolism under thermal stress., PMID:40360527
Targeting overexpressed HSPA8 by halofuginone suppresses aberrant proliferation and invasion of rheumatoid arthritis fibroblast-like synoviocytes., PMID:40339966
Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis., PMID:40338234
Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex., PMID:40327696
Rituximab-Chidamide combination chemotherapy enhances autophagy to overcome drug resistance in diffuse large B-cell lymphoma., PMID:40258315
HDCA alleviates Parkinson's disease symptoms by promoting autophagic degradation of α-synuclein in enteric neurons., PMID:40252434
HSPA8 and HSPA9: Two prognostic and therapeutic targets in breast, colon, and kidney cancers?, PMID:40189113
Stepwise recruitment of chaperone Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibril disassembly., PMID:40159506
RBMS1-HSPA8 axis activation drives head and neck squamous cell carcinoma progression., PMID:40140757
Integrative proteomic and lipidomic analysis of GNB1 and SCARB2 knockdown in human subcutaneous adipocytes., PMID:40127054
Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease., PMID:40122840
NDRG1 alleviates Erastin-induced ferroptosis of hepatocellular carcinoma., PMID:40119318
Chaperone-mediated autophagy degrades SERPINA1E342K/α1-antitrypsin Z variant and alleviates cell stress., PMID:40114294
Circular RNA circHSPA8 Aggravates Metastasis by Acting as a Competitive Inhibitor of miR-195-5p to Upregulate WNT3A Expression in Breast Cancer., PMID:40099939
Subacute exposure of male adolescent rats to 2,2',5,5'-tetrachlorobiphenyl-4-ol via a polymeric implant causes gene expression changes in the brain and metabolomic disruption in serum., PMID:40097135
Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach., PMID:39996454
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation., PMID:39977267
Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer., PMID:39955556
MSC-EV-transmitted HSPA8 alleviates cisplatin-induced ovotoxicity by regulating the MGARP/PRDX2 axis., PMID:39952536
Secretome and Proteome of Extracellular Vesicles Provide Protein Markers of Lung and Colorectal Cancer., PMID:39940785
Transcriptional dynamics of porcine granulosa cells during cellular acclimation to thermal challenge., PMID:39923387
Chaperone-mediated autophagy contributes to chromosomal stability by controlling TTC28 degradation., PMID:39893561
Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells., PMID:39882071
The underlying mechanisms of the association of bone health with depression - an experimental study., PMID:39869252
Pristimerin Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proliferation., PMID:39813169
Identification of key genes associated with oxidative stress in ischemic stroke via bioinformatics integrated analysis., PMID:39806309
Spatial Genomics Identifies Heat Shock Proteins as Key Molecular Changes Associated to Adipose Periprostatic Space Invasion in Prostate Cancer., PMID:39796635
LAP1 Interactome Profiling Provides New Insights into LAP1's Physiological Functions., PMID:39769001
Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma., PMID:39747468
Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis., PMID:39737952
Corrigendum to: HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells., PMID:39719882
HSP mRNA sequences and their expression under different thermal oscillation patterns and heat stress in two populations of Nodipecten subnodosus., PMID:39706547
Autophagy promotes p72 degradation and capsid disassembly during the early phase of African swine fever virus infection., PMID:39688418
Molecular response of canine testis to GnRH agonist: Insights into AR, HIF-1α, and HSPs expression during arrest and recovery of spermatogenesis., PMID:39631561
The essential role of TTC28 in maintaining chromosomal stability via HSPA8 chaperone-mediated autophagy., PMID:39630868
Single nuclear RNA sequencing and analysis of basal cells in pulmonary acute respiratory distress syndrome., PMID:39622393
Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis., PMID:39611307
In Silico Discovery and Evaluation of Inhibitors of the SARS-CoV-2 Spike Protein-HSPA8 Complex Towards Developing COVID-19 Therapeutic Drugs., PMID:39599841
Exploring the Antiviral Potential of Artemisia annua Through JAK-STAT Pathway Targeting: A Network Pharmacology Approach., PMID:39598448
Comparison of Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis Lipid Extracts Effects on UVA-Induced Changes in Human Skin Fibroblasts Proteome., PMID:39590789
Transcriptome analysis of jejunal mucosal tissue in breeder hens exposed to acute heat stress., PMID:39561558
Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation., PMID:39543624
Single-cell sequencing combined with transcriptomics and in vivo and in vitro analysis reveals the landscape of ferroptosis in myocardial ischemia-reperfusion injury., PMID:39520298
For research use only. Not for human or drug use.
