Catalog No.
YHC82801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp29-Phe209
Predicted molecular weight
23.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10646
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Extrinsic pathway inhibitor, Lipoprotein-associated coagulation inhibitor, TFPI, EPI, LACI, TFPI1, Tissue factor pathway inhibitor
Mediating Role of the ANGPTL3/TFPI Protein Ratio in Regulating T-Cell Surface Glycoprotein CD5 Levels on Knee Osteoarthritis (KOA): A Mendelian Randomization Study., PMID:40429617
Characterization of the Endothelial, Coagulofibrinolytic and Inflammatory Profile in Burn Patients after Resuscitation with Fresh Frozen Plasma., PMID:40402034
Evaluating the Safety and Efficacy of Concizumab in Hemophilia A/B Patients: A Systematic Review., PMID:40368339
Effect of bone marrow blood versus peripheral blood on the hemostatic balance of osteoblasts and endothelial cells., PMID:40258877
Revolutionizing Treatment Strategies through Inhibition of Tissue Factor Pathway Inhibitor: A Promising Therapeutic Approach for Hemophilia Management., PMID:40200623
The effect of combined oral contraceptives on thrombin generation assessed on ST Genesia- a paired clinical study., PMID:40200315
Vitamin D Supplementation Effects on Markers Related with Endothelial Function and Coagulation in Obese Orthopedic Patients: Insights from Acute and Chronic Cases., PMID:40077751
Tissue factor pathway inhibitor levels and atherothrombotic events in patients with chronic kidney disease or diabetes., PMID:40064839
Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review., PMID:39971274
YTHDF2-mediated m6A modification of ONECUT2 promotes stemness and oxaliplatin resistance in gastric cancer through transcriptionally activating TFPI., PMID:39823826
Chemotherapy alters thrombomodulin and factor VIIIc expression resulting in acquired activated protein C resistance and enhanced thrombin generation in cancer associated thrombosis., PMID:39793535
Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation., PMID:39766213
Olink Profiling of Intestinal Tissue Identifies Novel Biomarkers For Colorectal Cancer., PMID:39757570
Molecular Display of the Animal Meta-Venome for Discovery of Novel Therapeutic Peptides., PMID:39746545
Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection., PMID:39738466
Elevated tissue factor pathway inhibitor is associated with intracerebral haemorrhage of unknown cause in young adults., PMID:39737585
Marstacimab: First Approval., PMID:39715914
Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial., PMID:39661372
Importance of individual residues in hydrophobic patch PLVIVGL (1481-1487) in FV-Short for synergistic TFPIα cofactor activity with protein S, an alanine-scanning study: AlphaFold-mediated prediction of FV-Short/TFPIα/protein S trimolecular complex structure., PMID:39617184
Citrullination of tissue factor pathway inhibitor alpha by peptidylarginine deiminase 4 impairs its natural anticoagulant activity toward factors Xa and VIIa/tissue factor and reduces binding to its cofactor protein S., PMID:39613106
Protective effects of tissue factor pathway inhibitor on mice with lipopolysaccharide-induced acute lung injury., PMID:39603553
A new look at TFPI inhibition of factor X activation., PMID:39546494
Examining downstream effects of concizumab in hemophilia A with a mathematical modeling approach., PMID:39536817
Functionally distinct anticoagulant mechanisms of endothelial cells., PMID:39522336
Effect of therapeutic plasma exchange on tissue factor and tissue factor pathway inhibitor in septic shock., PMID:39478586
The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding., PMID:39365993
[Advances in hemophilia treatment]., PMID:39358264
Tissue factor pathway inhibitor - cofactor-dependent regulation of the initiation of coagulation., PMID:39259668
A high-calcium environment induced ectopic calcification of renal interstitial fibroblasts via TFPI-2-DCHS1-ALP/ENPP1 axis to participate in Randall's plaque formation., PMID:39196305
Tissue factor pathway inhibitor-2 (TFPI-2)-an underappreciated partaker in cancer and metastasis., PMID:39153052
Tissue-specific sex-dependent difference in the metabolism of fatty acid esters of hydroxy fatty acids., PMID:39097081
Prediction of Peripheral Artery Disease Prognosis Using Clinical and Inflammatory Biomarker Data., PMID:39070129
Elevated TFPI is a prognostic factor in hepatocellular carcinoma: Putative role of miR-7-5p and miR-1236-3p., PMID:38945092
Tissue factor regulates autophagy in pulmonary artery endothelial cells from chronic thromboembolic pulmonary hypertension rats via the p38 MAPK-FoxO1 pathway., PMID:38943142
Deletion of tissue factor pathway inhibitor isoform beta or gamma, but not alpha, improves clotting in hemophilic mice., PMID:38925489
Minimal interference of concizumab with standard clinical coagulation laboratory assays - An in vitro study., PMID:38924198
MEK1/2- and ERK1/2-Mediated Lung Endothelial Injury and Altered Hemostasis Promote Diffuse Alveolar Hemorrhage in Murine Lupus., PMID:38923837
Associations of tissue factor and tissue factor pathway inhibitor with organ dysfunctions in septic shock., PMID:38914630
Targeting tissue factor pathway inhibitor with concizumab to improve hemostasis in patients with Glanzmann thrombasthenia: an in vitro study., PMID:38880178
Mutational analysis of pig tissue factor pathway inhibitor α to increase anti-coagulation activity in pig-to-human xenotransplantation., PMID:38872071
Molecular Display of the Animal Meta-Venome for Discovery of Novel Therapeutic Peptides., PMID:38854075
Exploration on the effect of anserine on the alleviation of DVT and its molecular mechanism., PMID:38846090
Proteome-Wide Multicenter Mendelian Randomization Analysis to Identify Novel Therapeutic Targets for Lung Cancer., PMID:38824092
Concizumab improves clot formation in hemophilia A under flow., PMID:38815755
MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupus., PMID:38766226
Comparative analysis of dynamic transcriptomes reveals specific COVID-19 features and pathogenesis of immunocompromised populations., PMID:38752789
TFPI from erythroblasts drives heme production in central macrophages promoting erythropoiesis in polycythemia., PMID:38729948
Engineering and evaluation of FXa bypassing agents that restore hemostasis following Apixaban associated bleeding., PMID:38724509
Tissue Factor Pathway Inhibitor and Interleukin-1 Receptor Levels in COVID-19., PMID:38677277
For research use only. Not for human or drug use.
