Catalog No.
YHC82401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu758
Predicted molecular weight
81.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10636
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAPTL, Paired helical filament-tau, MTBT1, Microtubule-associated protein tau, TAU, Neurofibrillary tangle protein, MAPT, PHF-tau
Influence of ethnicity on the diagnostic accuracy of plasma p-tau217 for the identification of Alzheimer's disease: A consecutive mixed memory clinic cohort study., PMID:40501109
β-Amyloid as a new target to suppress tonic PTH hypersecretion in primary hyperparathyroidism., PMID:40492090
Cell-type-specific Transcriptomic-wide Association Studies Detected 91 Independent Risk Genes for Alzheimer's Disease Dementia., PMID:40492066
Integrating plasma p-tau217 and digital cognitive assessments for early detection in Alzheimer's disease., PMID:40491259
Neuropathological examination of 12 cases of familial Parkinson's disease with LRRK2 I2020T mutation including tau and TDP-43 pathology., PMID:40488901
Uncovering Ethnicity-Specific Recessive Loci for Alzheimer's Disease in 89 Dominican Families Using Family-Based WGS Analysis., PMID:40488219
Molecular signatures of regional vulnerability to tauopathy in excitatory cortical neurons., PMID:40481857
Rewired m6A of promoter antisense RNAs in Alzheimer's disease regulates neuronal genes in 3D nucleome., PMID:40480976
Untangling hidden players of PCOS: From transcriptomics to key biomarkers using WGCNA, LASSO and ROC analysis., PMID:40480394
Diagnostic performance of plasma p-tau217 and Aβ42/40 biomarkers in the outpatient memory clinic., PMID:40476540
Multiplex digital spatial profiling identifies subregion dependent targeted proteome changes across variants of dementia., PMID:40476255
Association of Plasma Phosphorylated Tau 217 With Clinical Deterioration Across Alzheimer Disease Stages., PMID:40472304
Alzheimer's disease plasma biomarkers in the Midwestern Amish., PMID:40465679
[Cerebrospinal Fluid Biomarker Profile in Atypical Alzheimer's Disease]., PMID:40464420
Revisiting the therapeutic landscape of tauopathies: assessing the current pipeline and clinical trials., PMID:40462159
Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases., PMID:40447946
Repeated plasma p-tau217 measurements to monitor clinical progression heterogeneity., PMID:40442871
Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life., PMID:40442822
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference., PMID:40437880
Depressive symptoms interact with CSF levels of p-tau in predicting cognitive performance in the early stages of Parkinson's disease., PMID:40435794
Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers., PMID:40432308
The Role of Tau in Neuronal Function and Neurodegeneration., PMID:40423231
Phenylacetylglutamine produced from injury lung alveolar epithelial cells promotes the function of BMSCs by regulating NONRATT006276.2/Mapt pathway., PMID:40413470
The performance of plasma p-tau217 in Black middle-aged and older adults., PMID:40410928
Sequence and trajectory of early Alzheimer's disease-related tau inclusions in the hippocampal formation of cases without amyloid-β deposits., PMID:40407905
hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation., PMID:40390134
Glucose starvation induces tau phosphorylation leading to cellular stress response in fission yeast., PMID:40387938
Tomatidine Ameliorates Diabetes-Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK-TFEB Pathway., PMID:40387453
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration., PMID:40380000
A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC., PMID:40379966
Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease., PMID:40373247
Assessment of Plasma and Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease and Other Dementias: A Center-Based Study., PMID:40362548
The Intersection of Genetics and Neuroimaging: A Systematic Review of Imaging Genetics in Neurological Disease for Personalized Treatment., PMID:40360788
Associations between Aβ40, Aβ42, and tau and postoperative delirium in older adults undergoing cardiac surgery., PMID:40355623
Combination of RNA-sequencing data analysis, network pharmacology, molecular docking techniques to investigate the mechanism of Prunella vulgaris L. in the treatment of non-small cell lung cancer., PMID:40353950
Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit., PMID:40348819
Study on the effect and mechanism of PM2.5 on the expression of Alzheimer's disease-like pathological proteins in SH-SY5Y cells., PMID:40348349
Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology., PMID:40348205
Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate., PMID:40346521
ANXA11 Mutations in the FTD Spectrum: A Novel Finding in a Patient With Semantic Variant Primary Progressive Aphasia., PMID:40345169
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry., PMID:40333995
High Tau expression correlates with reduced invasion and prolonged survival in Ewing sarcoma., PMID:40319030
The interactome of tau phosphorylated at T217 in Alzheimer's disease human brain tissue., PMID:40317322
Differences in Alzheimer's disease blood biomarker stability: Implications for the use of tau/amyloid ratios., PMID:40308118
A Novel Phosphorylated Tau Conformer Implicated in the Tauopathy Pathogenesis of Human Neurons., PMID:40305319
Functional Specificity of Astrocyte Subtypes in Alzheimer's Disease: Decoding Disease Mechanisms Through Network-based Analysis of Integrated Single-Nuclei Multi-Omic Data., PMID:40301248
Splicing factor PTBP1 promotes hepatocarcinogenesis via oncogenic splice-switching of MAPT., PMID:40296916
NRN1 may Modulate Tau Phosphorylation and Neuronal Apoptosis in AD via the PIGU-CASP3 Axis., PMID:40296620
Cerebrospinal Fluid Biomarkers for Alzheimer Disease Among Patients With Dementia., PMID:40293734
Association between high plasma p-tau181 level and gait changes in patients with mild cognitive impairment., PMID:40287471
For research use only. Not for human or drug use.
