Catalog No.
YHC78901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr28-Leu158
Predicted molecular weight
17.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10124
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Platelet proteoglycan core protein, Secretory granule proteoglycan core protein, PRG1, PRG, P.PG, Serglycin, Hematopoietic proteoglycan core protein, SRGN
The interaction of HT-2 toxin and Akt1 on gene expression regulation in Kashin-Beck disease pathogenesis., PMID:40449756
SRGN-mediated reactivation of the YAP/CRISPLD2 axis promotes aggressiveness of hepatocellular carcinoma., PMID:40384866
Computational prediction of Homo sapiens-Candida albicans protein-protein interactions reveal key virulence factors using dual RNA-Seq data analysis., PMID:40188396
Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression., PMID:40140646
Glypican3 and serglycin as potential biomarkers involved in the pathogenesis of ovarian endometriosis., PMID:40139079
Expansion of peripheral cytotoxic CD4+ T cells in Alzheimer's disease: New insights from multi-omics evidence., PMID:39657893
SRGN promotes macrophage recruitment through CCL3 in osteoarthritis., PMID:39067006
The relationship between tumor immunity and the cGAS-STING pathway in breast cancer: An immunohistochemical study., PMID:39053305
CCAAT/enhancer-binding protein α-dependent regulation of granule formation in mast cells by intestinal bacteria., PMID:38980255
Serglycin controls megakaryocyte retention of platelet factor 4 and influences megakaryocyte fate in bone marrow., PMID:38941534
Tumour cell-derived serglycin promotes IL-8 secretion of CAFs in gastric cancer., PMID:38862740
The Expression of Serglycin Is Required for Active Transforming Growth Factor β Receptor I Tumorigenic Signaling in Glioblastoma Cells and Paracrine Activation of Stromal Fibroblasts via CXCR-2., PMID:38672477
OralExplorer: a web server for exploring the mechanisms of oral inflammatory diseases., PMID:38491529
Ceftriaxone averts neuroinflammation and relieves depressive-like behaviors via GLT-1/TrkB signaling., PMID:38310688
SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury., PMID:38287411
Integrated Bioinformatic Analysis of Differentially Expressed Genes Associated with Wound Healing., PMID:38192258
Identification of the immune-associated characteristics and predictive biomarkers of keratoconus based on single-cell RNA-sequencing and bulk RNA-sequencing., PMID:37965330
Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors., PMID:37924708
Identification of Candidate Biomarkers of Alzheimer's Disease via Multiplex Cerebrospinal Fluid and Serum Proteomics., PMID:37762527
MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study., PMID:37391754
Multi-omics analysis of Siglec family genes in cutaneous melanoma., PMID:37207210
Integrative network-based analysis on multiple Gene Expression Omnibus datasets identifies novel immune molecular markers implicated in non-alcoholic steatohepatitis., PMID:37008925
Decellularised spinal cord matrix manipulates glial niche into repairing phase via serglycin-mediated signalling pathway., PMID:36807637
M6PR- and EphB4-Rich Exosomes Secreted by Serglycin-Overexpressing Esophageal Cancer Cells Promote Cancer Progression., PMID:36632458
Evaluation of human platelet granules by structured illumination laser fluorescence microscopy., PMID:36572649
Cathepsin L promotes chemresistance to neuroblastoma by modulating serglycin., PMID:36133820
GLI1-rearranged mesenchymal tumor in the ovary., PMID:36053785
Identification of Key Biomarkers and Immune Infiltration in Liver Tissue after Bariatric Surgery., PMID:35789605
STAT3 regulates SRGN and promotes metastasis of nasopharyngeal carcinoma through the FoxO1-miR-148a-5p-CREB1 axis., PMID:35562411
Exosomal miR-106a-5p accelerates the progression of nasopharyngeal carcinoma through FBXW7-mediated TRIM24 degradation., PMID:35293097
Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability., PMID:35019721
miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin., PMID:34924500
Serglycin Is Involved in Adipose Tissue Inflammation in Obesity., PMID:34872979
[Identification of serum peptide biomarker for ovarian cancer diagnosis by Clin-TOF-II-MS combined with magnetic beads technology]., PMID:34794222
Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone., PMID:34556636
SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas., PMID:34524427
Serglycin promotes proliferation, migration, and invasion via the JAK/STAT signaling pathway in osteosarcoma., PMID:34493692
Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases., PMID:34244505
Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype., PMID:34059749
Epigenetic Landscape Analysis of the Long Non-Coding RNA and Messenger RNA in a Mouse Model of Corneal Alkali Burns., PMID:33891681
Cancer-associated fibroblasts secrete hypoxia-induced serglycin to promote head and neck squamous cell carcinoma tumor cell growth in vitro and in vivo by activating the Wnt/β-catenin pathway., PMID:33651283
Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential., PMID:33543029
Significance of serglycin and its binding partners in autocrine promotion of metastasis in esophageal cancer., PMID:33456569
Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin., PMID:33448622
The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy., PMID:33314317
Identification of Common Differentially Expressed Genes and Potential Therapeutic Targets in Ulcerative Colitis and Rheumatoid Arthritis., PMID:33262784
Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome., PMID:33110154
Molecular signature of extracellular matrix pathology in schizophrenia., PMID:33070392
Serum proteomics analysis of candidate predictive biomarker panel for the diagnosis of trastuzumab-based therapy resistant breast cancer., PMID:32887021
SRGN, a new identified shear-stress-responsive gene in endothelial cells., PMID:32712749
For research use only. Not for human or drug use.
