Catalog No.
RHE78201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:1000-1:2000
Target
CAK1, Cyclin-dependent kinase 7, MO15, p39 Mo15, STK1, CDKN7, CDK7, CDK-activating kinase 1, 39 kDa protein kinase, TFIIH basal transcription factor complex kinase subunit, Cell division protein kinase 7, CAK, Serine/threonine-protein kinase 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P50613
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1Y08
Antibody-drug conjugates targeting SSEA-4 inhibits growth and migration of SSEA-4 positive breast cancer cells., PMID:39798832
DNp73 enhances tumor progression and immune evasion in multiple myeloma by targeting the MYC and MYCN pathways., PMID:39380995
Selective but not pan-CDK inhibition abrogates 5-FU-driven tissue factor upregulation in colon cancer., PMID:38719932
Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency., PMID:37591314
An Overview of CDK Enzyme Inhibitors in Cancer Therapy., PMID:36959160
Inhibition of MYC suppresses programmed cell death ligand-1 expression and enhances immunotherapy in triple-negative breast cancer., PMID:36583862
Systematic illumination of druggable genes in cancer genomes., PMID:35196490
CDK inhibitors in cancer therapy, an overview of recent development., PMID:34094661
Advances in Therapy for Hormone Receptor (HR)-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Advanced Breast Cancer Patients Who Have Experienced Progression After Treatment with CDK4/6 Inhibitors., PMID:33976551
G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181., PMID:33352782
CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer., PMID:32690037
Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma., PMID:32653773
Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells., PMID:31755214
Transcriptional targeting of oncogene addiction in medullary thyroid cancer., PMID:30135308
Selective inhibition of CDK7 ameliorates experimental arthritis in mice., PMID:25149277
Nascent histamine induces α-synuclein and caspase-3 on human cells., PMID:25124665
Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation., PMID:19487459
A scoring system for the follow up study of nuclear receptor coactivator complexes., PMID:16862220
Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells., PMID:15695176
[Analysis of transient G1/S arrest in E1A+E1B-19kDa transformed cells after ionizing radiation]., PMID:15027353
Two forms of RNA polymerase II holoenzyme display different abundance during the cell cycle., PMID:12615059
Functional coupling of capping and transcription of mRNA., PMID:12408827
Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II., PMID:12185079
Cyclin H is a new binding partner for protein kinase CK2., PMID:12147220
Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera., PMID:12118371
Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein., PMID:12007796
Modulation of MDM2/p53 and cyclin-activating kinase during the megakaryocyte differentiation of human erythroleukemia cells., PMID:11823051
Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome., PMID:11259578
Molecular structure of human TFIIH., PMID:11007478
Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins., PMID:10958787
Analysis of CAK activities from human cells., PMID:10866826
Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity., PMID:10611320
The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes., PMID:10590085
A rice homolog of Cdk7/MO15 phosphorylates both cyclin-dependent protein kinases and the carboxy-terminal domain of RNA polymerase II., PMID:10036778
An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor., PMID:9891058
Heat-shock-specific phosphorylation and transcriptional activity of RNA polymerase II., PMID:9665818
Differential expression of G1 cyclins and cyclin-dependent kinase inhibitors in normal and transformed melanocytes., PMID:9579467
Changes in cyclin B during oocyte maturation and early embryonic cell cycle in the newt, Cynops pyrrhogaster: requirement of germinal vesicle for MPF activation., PMID:9520324
Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone., PMID:9331337
The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies., PMID:9243502
Translocation of cdk2 to the nucleus during G1-phase in PDGF-stimulated human fibroblasts., PMID:9141623
Regulation of CDK7 substrate specificity by MAT1 and TFIIH., PMID:9130709
Protein kinase C inhibits the CAK-CDK2 cyclin-dependent kinase cascade and G1/S cell cycle progression in human diploid fibroblasts., PMID:9244189
Biochemical characterization of the human cyclin-dependent protein kinase activating kinase. Identification of p35 as a novel regulatory subunit., PMID:8550604
A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation., PMID:7553866
Cdk-activating kinase complex is a component of human transcription factor TFIIH., PMID:7533895
Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase., PMID:8208556
For research use only. Not for human or drug use.
