Catalog No.
RHE71001
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Applications
WB
Recommended Dilution
| Application |
Dilution |
| WB |
1:1000-1:2000 |
Target
AP3Aase, Bis(5'-adenosyl)-triphosphatase, FHIT, Dinucleosidetriphosphatase, Fragile histidine triad protein, AP3A hydrolase, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49789
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1X74
Note
For research use only.
Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities., PMID:9393735
The FHIT gene product is highly expressed in the cytoplasm of renal tubular epithelium and is down-regulated in kidney cancers., PMID:9403704
Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family., PMID:9770345
Loss of FHIT function in lung cancer and preinvasive bronchial lesions., PMID:9823304
The molecular pathology of Barrett's esophagus., PMID:10212817
Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells., PMID:10675384
Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features., PMID:10735505
Fhit expression is absent or reduced in a subset of primary head and neck cancer., PMID:10810397
Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression., PMID:10850413
Msh2, Mlh1, Fhit, p53, Bcl-2, and Bax expression in invasive and in situ squamous cell carcinoma of the uterine cervix., PMID:10999751
Primary cervical carcinomas show 2 common regions of deletion at 3P, 1 within the FHIT gene: evaluation of allelic imbalance at FHIT, RB1 and TP53 in relation to survival., PMID:11004671
Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor., PMID:11051208
The pagetoid variant of urothelial carcinoma in situ of urinary bladder in a cow., PMID:11199158
FHIT gene expression in human urinary bladder transitional cell carcinomas., PMID:11317523
FHIT (fragile histidine triad) gene analysis in cervical intraepithelial neoplasia., PMID:11531281
Fhit protein expression in oral epithelium: immunohistochemical evaluation of three antisera., PMID:11724301
Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions., PMID:11875703
FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study., PMID:12090476
Preferential loss of Fhit expression in signet-ring cell and Krukenberg subtypes of gastric cancer., PMID:12218081
Loss of Fhit expression in testicular germ cell tumors and intratubular germ cell neoplasia., PMID:12379753
[Loss of fragile histidine triad expression and metastasis in breast cancer]., PMID:12452072
Immunohistochemical detection of cell cycle regulators, Fhit protein and apoptotic cells in parathyroid lesions., PMID:12534361
Down-regulation of fragile histidine triad expression in prostate carcinoma., PMID:12627509
Tumour suppressor gene expression correlates with gastric cancer prognosis., PMID:12692839
Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters., PMID:12702909
Abnormal fragile histidine triad expression in advanced cervical cancer and evaluation of its utility as a prognostic factor., PMID:12837987
Immunohistochemical expression of FHIT gene product in inflammatory bowel disease: significance and correlation with clinicopathological data., PMID:12840679
Reduced Fhit expression in cervical carcinoma: correlation with tumor progression and poor prognosis., PMID:12893195
Identification of novel proteins associated with hepatocellular carcinomas using protein microarrays., PMID:14517841
Alterations in the common fragile site gene Parkin in ovarian and other cancers., PMID:14614460
Expression of the fragile histidine triad gene in normal rat tissues and human kidney cancer cell lines., PMID:15080505
FHIT expression in neoplastic, hyperplastic, and normal endometrium., PMID:16343185
Biochemical and immunochemical characterisation of human diadenosine triphosphatase provides evidence for its identification with the tumour suppressor Fhit protein., PMID:16359767
[The relationship between expression of Fhit and biological behaviors of hypopharyngeal carcinoma]., PMID:16739375
Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer., PMID:16819513
Loss of fragile histidine triad protein expression in inflammatory bowel disease., PMID:17143956
Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells., PMID:18006149
Magnetic enrichment of bronchial epithelial cells from sputum for lung cancer diagnosis., PMID:18484646
Immunohistochemical assessment of Fhit protein expression in advanced gastric carcinomas in correlation with Helicobacter pylori infection and survival time., PMID:19419937
Molecular cloning of the canine fragile histidine triad (FHIT) gene and Fhit protein expression in canine peripheral blood mononuclear cells., PMID:19498293
High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma., PMID:19759907
The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes., PMID:20183797
Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study., PMID:21394649
Preclinical rationale for combining an EGFR antibody with cisplatin/gemcitabine for the treatment of NSCLC., PMID:22399498
The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells., PMID:22451343
Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells., PMID:24464917
Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma., PMID:25622532
Expression of FHIT, p16, p53 and EGFR as prognostic markers in thyroid tumors of uncertain malignant potential., PMID:26011351
Loss of heterozygosity of key tumor suppressor genes in advanced renal cancer patients treated with nivolumab., PMID:30008256
FHITlow /pHER2high signature in non-small cell lung cancer is predictive of anti-HER2 molecule efficacy., PMID:32237123
For research use only. Not for human or drug use.
