Catalog No.
RHE71001
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:1000-1:2000
Target
AP3Aase, Bis(5'-adenosyl)-triphosphatase, FHIT, Dinucleosidetriphosphatase, Fragile histidine triad protein, AP3A hydrolase, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49789
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1X74
FHITlow /pHER2high signature in non-small cell lung cancer is predictive of anti-HER2 molecule efficacy., PMID:32237123
Loss of heterozygosity of key tumor suppressor genes in advanced renal cancer patients treated with nivolumab., PMID:30008256
Expression of FHIT, p16, p53 and EGFR as prognostic markers in thyroid tumors of uncertain malignant potential., PMID:26011351
Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma., PMID:25622532
Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells., PMID:24464917
The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells., PMID:22451343
Preclinical rationale for combining an EGFR antibody with cisplatin/gemcitabine for the treatment of NSCLC., PMID:22399498
Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study., PMID:21394649
The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes., PMID:20183797
High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma., PMID:19759907
Molecular cloning of the canine fragile histidine triad (FHIT) gene and Fhit protein expression in canine peripheral blood mononuclear cells., PMID:19498293
Immunohistochemical assessment of Fhit protein expression in advanced gastric carcinomas in correlation with Helicobacter pylori infection and survival time., PMID:19419937
Magnetic enrichment of bronchial epithelial cells from sputum for lung cancer diagnosis., PMID:18484646
Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells., PMID:18006149
Loss of fragile histidine triad protein expression in inflammatory bowel disease., PMID:17143956
Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer., PMID:16819513
[The relationship between expression of Fhit and biological behaviors of hypopharyngeal carcinoma]., PMID:16739375
Biochemical and immunochemical characterisation of human diadenosine triphosphatase provides evidence for its identification with the tumour suppressor Fhit protein., PMID:16359767
FHIT expression in neoplastic, hyperplastic, and normal endometrium., PMID:16343185
Expression of the fragile histidine triad gene in normal rat tissues and human kidney cancer cell lines., PMID:15080505
Alterations in the common fragile site gene Parkin in ovarian and other cancers., PMID:14614460
Identification of novel proteins associated with hepatocellular carcinomas using protein microarrays., PMID:14517841
Reduced Fhit expression in cervical carcinoma: correlation with tumor progression and poor prognosis., PMID:12893195
Immunohistochemical expression of FHIT gene product in inflammatory bowel disease: significance and correlation with clinicopathological data., PMID:12840679
Abnormal fragile histidine triad expression in advanced cervical cancer and evaluation of its utility as a prognostic factor., PMID:12837987
Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters., PMID:12702909
Tumour suppressor gene expression correlates with gastric cancer prognosis., PMID:12692839
Down-regulation of fragile histidine triad expression in prostate carcinoma., PMID:12627509
Immunohistochemical detection of cell cycle regulators, Fhit protein and apoptotic cells in parathyroid lesions., PMID:12534361
[Loss of fragile histidine triad expression and metastasis in breast cancer]., PMID:12452072
Loss of Fhit expression in testicular germ cell tumors and intratubular germ cell neoplasia., PMID:12379753
Preferential loss of Fhit expression in signet-ring cell and Krukenberg subtypes of gastric cancer., PMID:12218081
FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study., PMID:12090476
Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions., PMID:11875703
Fhit protein expression in oral epithelium: immunohistochemical evaluation of three antisera., PMID:11724301
FHIT (fragile histidine triad) gene analysis in cervical intraepithelial neoplasia., PMID:11531281
FHIT gene expression in human urinary bladder transitional cell carcinomas., PMID:11317523
The pagetoid variant of urothelial carcinoma in situ of urinary bladder in a cow., PMID:11199158
Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor., PMID:11051208
Primary cervical carcinomas show 2 common regions of deletion at 3P, 1 within the FHIT gene: evaluation of allelic imbalance at FHIT, RB1 and TP53 in relation to survival., PMID:11004671
Msh2, Mlh1, Fhit, p53, Bcl-2, and Bax expression in invasive and in situ squamous cell carcinoma of the uterine cervix., PMID:10999751
Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression., PMID:10850413
Fhit expression is absent or reduced in a subset of primary head and neck cancer., PMID:10810397
Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features., PMID:10735505
Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells., PMID:10675384
The molecular pathology of Barrett's esophagus., PMID:10212817
Loss of FHIT function in lung cancer and preinvasive bronchial lesions., PMID:9823304
Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family., PMID:9770345
The FHIT gene product is highly expressed in the cytoplasm of renal tubular epithelium and is down-regulated in kidney cancers., PMID:9403704
Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities., PMID:9393735
For research use only. Not for human or drug use.
