Catalog No.
RHE65901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:500-1:1000
Target
CENP-A, Centromere autoantigen A, CENPA, Centromere protein A, Histone H3-like centromeric protein A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49450
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1X42
Anti-Centromere Protein A Antibody Disrupts the Competence of Mouse Oocytes Matured In Vitro., PMID:39665768
Dysregulation of R-loop homeostasis shapes the immunosuppressive microenvironment and induces malignant progression in melanoma., PMID:39487313
Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective., PMID:39102671
Structural basis for Mis18 complex assembly and its implications for centromere maintenance., PMID:38951710
Native and tagged CENP-A histones are functionally inequivalent., PMID:38825690
Neuronal autoantibodies in the cerebrospinal fluid of 148 patients with schizophrenia and 151 healthy controls., PMID:38770306
Detection of IgE-autoantibodies to nuclear antigens in patients with systemic sclerosis and analysis of their clinical relevance., PMID:38530662
Interaction of histone H4 with Cse4 facilitates conformational changes in Cse4 for its sumoylation and mislocalization., PMID:38038247
Prevalence and Clinical Implications of Scleroderma-Specific Autoantibodies in Seronegative Patients with Sicca Complaints., PMID:37941855
Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability., PMID:37436802
Systemic sclerosis and primary biliary cholangitis share an antibody population with identical specificity., PMID:36715304
Autoantibodies and Clinical Correlations in Polish Systemic Sclerosis Patients: A Cross-Sectional Study., PMID:36675584
Autoantibodies associated with systemic sclerosis in three autoimmune diseases imprinted by type I interferon gene dysregulation: a comparison across SLE, primary Sjögren's syndrome and systemic sclerosis., PMID:36581379
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis., PMID:36400785
Genome-Wide Super-Enhancer-Based Analysis: Identification of Prognostic Genes in Oral Squamous Cell Carcinoma., PMID:36012427
Robertsonian Fusion and Centromere Repositioning Contributed to the Formation of Satellite-free Centromeres During the Evolution of Zebras., PMID:35881460
Pitfalls in establishing mouse model of female infertility by immunization with human centromere protein., PMID:34418489
Anticentromere antibody induced by immunization with centromere protein and Freund's complete adjuvant may interfere with mouse early-stage embryo., PMID:34416895
Combining multi-antigenic immunodot with indirect immunofluorescence on HEp-2 cells improves the diagnosis of systemic sclerosis., PMID:34111525
Protein-Based Immunome Wide Association Studies (PIWAS) for the Discovery of Significant Disease-Associated Antigens., PMID:33986742
Autoantibody profiles in systemic sclerosis; a comparison of diagnostic tests., PMID:33818234
Anticentromere antibody induced by immunization with centromere protein a and Freund's complete adjuvant may interfere with mouse oocyte meiosis., PMID:33794912
CENP-A Nucleosome is a Sensitive Allosteric Scaffold for DNA and Chromatin Factors., PMID:33387534
Spt6 is a maintenance factor for centromeric CENP-A., PMID:32522980
Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment., PMID:31127102
Evaluation of a commercial immunoassay for autoantibodies in Chinese Han systemic sclerosis population., PMID:30685360
Imaging and Quantitation of Assembly Dynamics of the Centromeric Histone H3 Variant CENP-A in Drosophila melanogaster Spermatocytes by Immunofluorescence and Fluorescence In-Situ Hybridization (Immuno-FISH)., PMID:30073536
Birth, evolution, and transmission of satellite-free mammalian centromeric domains., PMID:29712753
Identification of methylation sites and signature genes with prognostic value for luminal breast cancer., PMID:29642861
Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype., PMID:29369808
An Exploration of the Impact of Anticentromere Antibody on Early-Stage Embryo., PMID:29119119
Disease-related autoantibody profile in patients with systemic sclerosis., PMID:28749191
CENP-A regulates chromosome segregation during the first meiosis of mouse oocytes., PMID:28585134
Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais., PMID:28296274
Stepwise unfolding supports a subunit model for vertebrate kinetochores., PMID:28265097
Increased immunoreactivity against human cytomegalovirus UL83 in systemic sclerosis., PMID:28240591
Mass Spectrometry-Based Methodology for Identification of Native Histone Variant Modifications From Mammalian Tissues and Solid Tumors., PMID:28137567
Identifying Centromeric RNAs Involved in Histone Dynamics In Vivo., PMID:27372766
Subspecificities of anticentromeric protein A antibodies identify systemic sclerosis patients at higher risk of pulmonary vascular disease., PMID:27336883
Anticentromere antibody-positive primary Sjögren's syndrome: Epitope analysis of a subset of anticentromere antibody-positive patients., PMID:27161330
Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins., PMID:26967065
Anti-centromere protein A antibodies in systemic sclerosis: Significance and origin., PMID:26455561
Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes., PMID:26430472
Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis., PMID:26246178
A cross-sectional study of autoantibody profiles in the Waikato systemic sclerosis cohort, New Zealand., PMID:26022620
CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere., PMID:25727006
Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres., PMID:25556658
Lessons learned from counting molecules: how to lure CENP-A into the kinetochore., PMID:25500356
Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas., PMID:25421174
Centromere sliding on a mammalian chromosome., PMID:25413176