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Anti-CENPA Antibody (R1X42)

Catalog #:   RHE65901 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: WB
Accession: P49450
Overview

Catalog No.

RHE65901

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

WB: 1:500-1:1000

Target

CENP-A, Centromere autoantigen A, CENPA, Centromere protein A, Histone H3-like centromeric protein A

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P49450

Applications

WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1X42

Data Image
  • Western blot
    Western blot analysis of CENPA in K562, Hela lysates using CENPA antibody.
References

Anti-Centromere Protein A Antibody Disrupts the Competence of Mouse Oocytes Matured In Vitro., PMID:39665768

Dysregulation of R-loop homeostasis shapes the immunosuppressive microenvironment and induces malignant progression in melanoma., PMID:39487313

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective., PMID:39102671

Structural basis for Mis18 complex assembly and its implications for centromere maintenance., PMID:38951710

Native and tagged CENP-A histones are functionally inequivalent., PMID:38825690

Neuronal autoantibodies in the cerebrospinal fluid of 148 patients with schizophrenia and 151 healthy controls., PMID:38770306

Detection of IgE-autoantibodies to nuclear antigens in patients with systemic sclerosis and analysis of their clinical relevance., PMID:38530662

Interaction of histone H4 with Cse4 facilitates conformational changes in Cse4 for its sumoylation and mislocalization., PMID:38038247

Prevalence and Clinical Implications of Scleroderma-Specific Autoantibodies in Seronegative Patients with Sicca Complaints., PMID:37941855

Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability., PMID:37436802

Systemic sclerosis and primary biliary cholangitis share an antibody population with identical specificity., PMID:36715304

Autoantibodies and Clinical Correlations in Polish Systemic Sclerosis Patients: A Cross-Sectional Study., PMID:36675584

Autoantibodies associated with systemic sclerosis in three autoimmune diseases imprinted by type I interferon gene dysregulation: a comparison across SLE, primary Sjögren's syndrome and systemic sclerosis., PMID:36581379

Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis., PMID:36400785

Genome-Wide Super-Enhancer-Based Analysis: Identification of Prognostic Genes in Oral Squamous Cell Carcinoma., PMID:36012427

Robertsonian Fusion and Centromere Repositioning Contributed to the Formation of Satellite-free Centromeres During the Evolution of Zebras., PMID:35881460

Pitfalls in establishing mouse model of female infertility by immunization with human centromere protein., PMID:34418489

Anticentromere antibody induced by immunization with centromere protein and Freund's complete adjuvant may interfere with mouse early-stage embryo., PMID:34416895

Combining multi-antigenic immunodot with indirect immunofluorescence on HEp-2 cells improves the diagnosis of systemic sclerosis., PMID:34111525

Protein-Based Immunome Wide Association Studies (PIWAS) for the Discovery of Significant Disease-Associated Antigens., PMID:33986742

Autoantibody profiles in systemic sclerosis; a comparison of diagnostic tests., PMID:33818234

Anticentromere antibody induced by immunization with centromere protein a and Freund's complete adjuvant may interfere with mouse oocyte meiosis., PMID:33794912

CENP-A Nucleosome is a Sensitive Allosteric Scaffold for DNA and Chromatin Factors., PMID:33387534

Spt6 is a maintenance factor for centromeric CENP-A., PMID:32522980

Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment., PMID:31127102

Evaluation of a commercial immunoassay for autoantibodies in Chinese Han systemic sclerosis population., PMID:30685360

Imaging and Quantitation of Assembly Dynamics of the Centromeric Histone H3 Variant CENP-A in Drosophila melanogaster Spermatocytes by Immunofluorescence and Fluorescence In-Situ Hybridization (Immuno-FISH)., PMID:30073536

Birth, evolution, and transmission of satellite-free mammalian centromeric domains., PMID:29712753

Identification of methylation sites and signature genes with prognostic value for luminal breast cancer., PMID:29642861

Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype., PMID:29369808

An Exploration of the Impact of Anticentromere Antibody on Early-Stage Embryo., PMID:29119119

Disease-related autoantibody profile in patients with systemic sclerosis., PMID:28749191

CENP-A regulates chromosome segregation during the first meiosis of mouse oocytes., PMID:28585134

Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais., PMID:28296274

Stepwise unfolding supports a subunit model for vertebrate kinetochores., PMID:28265097

Increased immunoreactivity against human cytomegalovirus UL83 in systemic sclerosis., PMID:28240591

Mass Spectrometry-Based Methodology for Identification of Native Histone Variant Modifications From Mammalian Tissues and Solid Tumors., PMID:28137567

Identifying Centromeric RNAs Involved in Histone Dynamics In Vivo., PMID:27372766

Subspecificities of anticentromeric protein A antibodies identify systemic sclerosis patients at higher risk of pulmonary vascular disease., PMID:27336883

Anticentromere antibody-positive primary Sjögren's syndrome: Epitope analysis of a subset of anticentromere antibody-positive patients., PMID:27161330

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins., PMID:26967065

Anti-centromere protein A antibodies in systemic sclerosis: Significance and origin., PMID:26455561

Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes., PMID:26430472

Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis., PMID:26246178

A cross-sectional study of autoantibody profiles in the Waikato systemic sclerosis cohort, New Zealand., PMID:26022620

CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere., PMID:25727006

Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres., PMID:25556658

Lessons learned from counting molecules: how to lure CENP-A into the kinetochore., PMID:25500356

Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas., PMID:25421174

Centromere sliding on a mammalian chromosome., PMID:25413176

Datasheet

Document Download

Anti-CENPA Antibody (R1X42).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

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Anti-CENPA Antibody (R1X42) [RHE65901]
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