Catalog No.
RHE50201
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
KIAA0051, p195, IQGAP1, Ras GTPase-activating-like protein IQGAP1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P46940
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1W90
IQGAP1 promotes early B cell development, is essential for the development of marginal zone (MZ) B cells, and is critical for both T-dependent and T-independent antibody responses., PMID:39585462
In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia., PMID:38834690
Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer., PMID:37434399
Rgs16 promotes antitumor CD8+ T cell exhaustion., PMID:35622904
Identification of IQGAP1 as a SLC26A4 (Pendrin)-Binding Protein in the Kidney., PMID:35601831
Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells., PMID:34076498
Interaction of microtubules and actin during the post-fusion phase of exocytosis., PMID:31427591
CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration., PMID:31040262
The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse., PMID:28167682
A new approach for the direct visualization of the membrane cytoskeleton in cryo-electron microscopy: a comparative study with freeze-etching electron microscopy., PMID:27587510
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer., PMID:26919099
Transforming growth factor-β inhibits IQ motif containing guanosine triphosphatase activating protein 1 expression in lung fibroblasts via the nuclear factor-κB signaling pathway., PMID:25684348
IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation., PMID:25675045
Hepatocyte growth factor-induced Asef-IQGAP1 complex controls cytoskeletal remodeling and endothelial barrier., PMID:25492863
Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry., PMID:25329145
Isolation of the lateral border recycling compartment using a diaminobenzidine-induced density shift., PMID:24915828
IQ domain GTPase-activating protein 1 is involved in shear stress-induced progenitor-derived endothelial cell alignment., PMID:24278215
IQGAP1 expression in spared CA1 neurons after an excitotoxic lesion in the mouse hippocampus., PMID:23907317
Protein 4.1R regulates cell migration and IQGAP1 recruitment to the leading edge., PMID:21750196
IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance., PMID:21724847
IQGAP1 regulates NR2A signaling, spine density, and cognitive processes., PMID:21653857
Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways., PMID:21478254
CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology., PMID:21430156
Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase., PMID:21304987
The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome., PMID:19815536
Identification and characterization of Ibe, a novel type III effector protein of A/E pathogens targeting human IQGAP1., PMID:19134119
Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos., PMID:18662680
Site-specific expression of IQGAP1, a key mediator of cytoskeleton, in mouse renal tubules., PMID:18413651
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells., PMID:17957782
Characterization of IQGAP1-containing complexes in NK-like cells: evidence for Rac 2 and RACK1 association during homotypic adhesion., PMID:17269730
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth., PMID:17244649
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex., PMID:15994232
Expression pattern of the scaffold protein IQGAP1 in lung cancer., PMID:15706411
Identification of protein-protein interactions using in vivo cross-linking and mass spectrometry., PMID:15540166
Isolation and characterization of 190K protein from aorta smooth muscle., PMID:15098669
Identification of an IQGAP1/AKAP79 complex in beta-cells., PMID:12938160
Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development., PMID:12617831
RasGAP-like protein IQGAP1 is expressed by human keratinocytes and recognized by autoantibodies in association with bullous skin disease., PMID:12603848
Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites., PMID:11329369
Changes in E-cadherin associated with cytoplasmic molecules in well and poorly differentiated endometrial cancer., PMID:11027430
Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli., PMID:10793131
IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs., PMID:8670801
For research use only. Not for human or drug use.
