Catalog No.
YHC43801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly1240-Ser1462
Predicted molecular weight
28.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P09884
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
POLA1, POLA, DNA polymerase alpha catalytic subunit p180, DNA polymerase alpha catalytic subunit
DNA glycosylase (NEIL3) overexpression associated with low tumor immune infiltration and poor overall patient survival in endometrial cancer., PMID:40348794
Whole-exome sequencing screening for candidate genes and potential pathogenic variants associated with early-onset high myopia in 47 Chinese families., PMID:40175531
Discovery of novel serum peptide biomarkers for cholangiocarcinoma recurrence through MALDI-TOF MS and LC-MS/MS peptidome analysis., PMID:39833435
Transcriptome analysis reveals the DNA replication genes response to Vibrio anguillarum and NNV infection in Jinhu grouper (Epinephelus fuscoguttatus♀ × Epinephelus tukulal♂)., PMID:39813918
Transcriptional analysis reveals the suppression of RAD51 and disruption of the homologous recombination pathway during PEDV infection in IPEC-J2 cells., PMID:39731192
The evolving genetic landscape of telomere biology disorder dyskeratosis congenita., PMID:39198715
DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps., PMID:39191785
Synthetic lethality between ATR and POLA1 reveals a potential new target for individualized cancer therapy., PMID:39128273
The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial., PMID:38555285
(Re-)Viewing Role of Intracellular Glucose Beyond Extracellular Regulation of Glucose-Stimulated Insulin Secretion by Pancreatic Cells., PMID:38496986
Regulation of Cell Cycle Progression through RB Phosphorylation by Nilotinib and AT-9283 in Human Melanoma A375P Cells., PMID:38474202
CryoEM insights into RNA primer synthesis by the human primosome., PMID:38335062
Filaggrin-Associated Atopic Skin, Eye, Airways, and Gut Disease, Modifying the Presentation of X-Linked Reticular Pigmentary Disorder (XLPDR)., PMID:38165470
Single-cell transcriptomics reveals subtype-specific molecular profiles in Nrf2-deficient macrophages from murine atherosclerotic aortas., PMID:37965327
The Antitumor Effect of the DNA Polymerase Alpha Inhibitor ST1926 in Glioblastoma: A Proteomics Approach., PMID:37762371
Application of Protein-Protein Interaction Network Analysis in Order to Identify Cervical Cancer miRNA and mRNA Biomarkers., PMID:37746664
Pathogenic Genes for Congenital Microtia: A Bioinformatics Analysis., PMID:37643078
Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis., PMID:37452331
The splicing factor SNRPB promotes ovarian cancer progression through regulating aberrant exon skipping of POLA1 and BRCA2., PMID:37391593
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics., PMID:37349788
Recycling of modified H2A-H2B provides short-term memory of chromatin states., PMID:36750094
Characterization of DNA Polymerase Genes in Amazonian Amerindian Populations., PMID:36672794
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments., PMID:36260751
Structure of Tetrahymena telomerase-bound CST with polymerase α-primase., PMID:35831498
Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state., PMID:35578024
Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Adult Dermal Fibroblasts on Cervical Cancer Cells., PMID:35563525
Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions., PMID:35523900
NF-κB-Related Metabolic Gene Signature Predicts the Prognosis and Immunotherapy Response in Gastric Cancer., PMID:35036435
From Mendel laws to whole genetic association study to decipher the swine mulefoot phenotype., PMID:34974356
Antitumor activity of novel POLA1-HDAC11 dual inhibitors., PMID:34772529
Investigation of Key Signaling Pathways Associating miR-204 and Common Retinopathies., PMID:34646884
Establishment of myoblast cell line and identification of key genes regulating myoblast differentiation in a marine teleost, Sebastes schlegelii., PMID:34352298
Comparative analysis of non structural protein 1 of SARS-CoV2 with SARS-CoV1 and MERS-CoV: An in silico study., PMID:34121768
Molecular diagnosis of childhood immune dysregulation, polyendocrinopathy, and enteropathy, and implications for clinical management., PMID:33864888
Construction of Gene Modules and Analysis of Prognostic Biomarkers for Cervical Cancer by Weighted Gene Co-Expression Network Analysis., PMID:33816217
Role of Amygdalin in Blocking DNA Replication in Breast Cancer In Vitro., PMID:33535947
Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity., PMID:32920362
Longitudinal Analysis of Gene Expression Changes During Cervical Carcinogenesis Reveals Potential Therapeutic Targets., PMID:32489245
CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells., PMID:32161100
Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication., PMID:32075739
NK cell defects in X-linked pigmentary reticulate disorder., PMID:31672938
Aberrant ERG expression associates with downregulation of miR-4638-5p and selected genomic alterations in a subset of diffuse large B-cell lymphoma., PMID:31237044
The oncomir face of microRNA-206: A permanent miR-206 transfection study., PMID:30111166
Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline., PMID:29775245
Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α., PMID:29416919
Induction of senescence in cancer cells by 5'-Aza-2'-deoxycytidine: Bioinformatics and experimental insights to its targets., PMID:28802167
Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy., PMID:28320388
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis., PMID:27019227
Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer., PMID:26795696
Reconstruction of canine diffuse large B-cell lymphoma gene regulatory network: detection of functional modules and hub genes., PMID:25678421
For research use only. Not for human or drug use.
