Catalog No.
RME31501
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Applications
IF, IHC, WB
Recommended Dilution
| Application |
Dilution |
| IF |
1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000 |
Target
Nuclear receptor subfamily 2 group A member 1, HNF-4-alpha, HNF4A, Hepatocyte nuclear factor 4-alpha, NR2A1, TCF14, Transcription factor 14, Transcription factor HNF-4, TCF-14, HNF4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49698
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1V90
Note
For research use only.
Positivity for islet cell autoantibodies in patients with monogenic diabetes is associated with later diabetes onset and higher HbA1c level., PMID:24102923
Upregulation of hepatic melanocortin 4 receptor during rat liver regeneration., PMID:24433867
HNF-4α regulates expression of human ornithin carbamoyltransferase through interaction with two positive cis-acting regulatory elements located in the proximal promoter., PMID:25056436
Clinical and molecular characterization of maturity onset-diabetes of the young caused by hepatocyte nuclear factor-4 alpha mutation: red flags for prediction of the diagnosis., PMID:25266181
Characteristics of maturity onset diabetes of the young in a large diabetes center., PMID:26059258
Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells., PMID:26232425
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189
Treating young adults with type 2 diabetes or monogenic diabetes., PMID:27432078
Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α., PMID:27501760
Differentiation of human foreskin fibroblast-derived induced pluripotent stem cells into hepatocyte-like cells., PMID:27569862
Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors., PMID:27820600
Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry., PMID:27913849
[Effects of pargyline on histone methylation in promoter and enhancer regions and transcription of CYP3A4/3A7]., PMID:29911787
Monogenic Diabetes Accounts for 6.3% of Cases Referred to 15 Italian Pediatric Diabetes Centers During 2007 to 2012., PMID:28323911
DNA methylation controls unmethylated transcription start sites in the genome in trans., PMID:28470094
Comprehensive screening for monogenic diabetes in 89 Japanese children with insulin-requiring antibody-negative type 1 diabetes., PMID:28597946
Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients., PMID:28701371
Can Biomarkers Help Target Maturity-Onset Diabetes of the Young Genetic Testing in Antibody-Negative Diabetes?, PMID:29355436
More than kin, less than kind: one family and the many faces of diabetes in youth., PMID:29412391
Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study., PMID:29509884
A novel INS mutation in a family with maturity-onset diabetes of the young: Variable insulin secretion and putative mechanisms., PMID:29633446
Site-Specific Fluorescent Labeling of Antibodies and Diabodies Using SpyTag/SpyCatcher System for In Vivo Optical Imaging., PMID:29948640
IL-23 enhances the malignant properties of hepatoma cells by attenuation of HNF4α., PMID:29983862
Autoantibodies against ZnT8 are rare in Central-European LADA patients and absent in MODY patients, including those positive for other autoantibodies., PMID:30377089
Isolation and Expansion of Rat Hepatocytic Progenitor Cells., PMID:30536088
Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells., PMID:31612883
Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study., PMID:31704690
Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6., PMID:31924695
Systematic Genetic Study of Youth With Diabetes in a Single Country Reveals the Prevalence of Diabetes Subtypes, Novel Candidate Genes, and Response to Precision Therapy., PMID:32086287
Update on clinical screening of maturity-onset diabetes of the young (MODY)., PMID:32528556
Clinical and laboratory clues of maturity-onset diabetes of the young and determination of association with molecular diagnosis., PMID:32710514
Immunohistochemical detection of hepatocyte nuclear factor-4α in vertebrates., PMID:34196449
Identification of Novel GCK and HNF4α Gene Variants in Japanese Pediatric Patients with Onset of Diabetes before 17 Years of Age., PMID:34746319
Functional screen of inflammatory bowel disease genes reveals key epithelial functions., PMID:34758847
Comprehensive genetic screening reveals wide spectrum of genetic variants in monogenic forms of diabetes among Pakistani population., PMID:34888019
Comparison of Different Hepatocyte Nuclear Factor 4α Clones for Invasive Mucinous Adenocarcinoma of the Lung., PMID:35510773
Identification of Variants Responsible for Monogenic Forms of Diabetes in Brazil., PMID:35592779
The coexistence of autoimmune diabetes and maturity-onset diabetes of the young (MODY): a case series., PMID:35894830
Study of the frequency and clinical features of maturity-onset diabetes in the young in the pediatric and adolescent diabetes population in Iran., PMID:36100423
Identification of monogenic variants in more than ten per cent of children without type 1 diabetes-related autoantibodies at diagnosis in the Finnish Pediatric Diabetes Register., PMID:36418577
OMIP-088: Twenty-target imaging mass cytometry panel for major cell populations in mouse formalin fixed paraffin embedded liver., PMID:36602064
Prevalence of maturity-onset diabetes of the young in phenotypic type 2 diabetes in young adults: a nationwide, multi-center, cross-sectional survey in China., PMID:36723869
Comprehensive proteomics and platform validation of urinary biomarkers for bladder cancer diagnosis and staging., PMID:37016361
High Frequency of Recessive WFS1 Mutations Among Indian Children With Islet Antibody-negative Type 1 Diabetes., PMID:37931151
Screening of Mutations in Maturity-onset Diabetes of the Young-related Genes and RFX6 in Children with Autoantibody-negative Type 1 Diabetes Mellitus., PMID:38054414
Hepatocyte nuclear factor 4 located in different developmental stages of Schistosoma japonicum and involved in important metabolic pathways., PMID:38621646
Clinical and Laboratory Characteristics of MODY Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship., PMID:38665000
Development of a clinical calculator to aid the identification of MODY in pediatric patients at the time of diabetes diagnosis., PMID:38719926
Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity., PMID:39364395
Molecular and clinical profiles of pediatric monogenic diabetes subtypes: comprehensive genetic analysis of 138 patients., PMID:39504571
For research use only. Not for human or drug use.
