Catalog No.
RHD95001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000
Target
RR2, Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit, Ribonucleoside-diphosphate reductase subunit M2, RRM2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P31350
Applications
IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1U21
Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses., PMID:38941598
Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer., PMID:37588202
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection., PMID:37434783
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo., PMID:37434215
USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2., PMID:37341611
Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM)., PMID:36315425
Palbociclib-based high-throughput combination drug screening identifies synergistic therapeutic options in HPV-negative head and neck squamous cell carcinoma., PMID:35546399
Identification of RRM2 in peripheral blood mononuclear cells as a novel biomarker for the diagnosis of rheumatoid arthritis., PMID:35200126
microRNA-20b-5p overexpression combing Pembrolizumab potentiates cancer cells to radiation therapy via repressing programmed death-ligand 1., PMID:34968160
CHK1 inhibition exacerbates replication stress induced by IGF blockade., PMID:34773074
Phosphorylated TAR DNA-binding protein-43: Aggregation and antibody-based inhibition., PMID:34339840
Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell-Free Expression Systems., PMID:33768661
Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction., PMID:33509941
Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein., PMID:32905837
Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma., PMID:32653773
The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status., PMID:26980146
The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism., PMID:24375594
Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA., PMID:24060417
Ligand-targeted particulate nanomedicines undergoing clinical evaluation: current status., PMID:24018362
Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent., PMID:23864387
Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43., PMID:23300771
Gene expression analysis in human breast cancer associated blood vessels., PMID:23056178
Regulation of urokinase expression at the posttranscription level by lung epithelial cells., PMID:22166006
Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma., PMID:20811706
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)., PMID:19815002
The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53., PMID:14583450
Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication., PMID:12414941
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements., PMID:10022872
Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal., PMID:7926751
For research use only. Not for human or drug use.
