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Recombinant Human CD48 Protein, N-His

Catalog #:   YHC39801 Specific References (99) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: P09326
Protein length: Gln27-Ser220
Overview

Catalog No.

YHC39801

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Gln27-Ser220

Predicted molecular weight

24.65 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P09326

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Signaling lymphocytic activation molecule 2, TCT.1, CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1, CD48, BLAST1, Leukocyte antigen MEM-102, SLAMF2, BCM1 surface antigen, SLAM family member 2

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human CD48 protein
References

Mast cell modulation of immune responses to bacteria. PMID: 11292019

Assessment of NK Cell Activity Based on NK Cell-Specific Receptor Synergy in Peripheral Blood Mononuclear Cells and Whole Blood. PMID: 33143099

A ligand for human CD48 on epithelial cells. PMID: 9378979

Regulation of T lymphocyte function by glycosylphosphatidylinositol (GPI)-anchored proteins. PMID: 8054537

Hematopoiesis Remains Permissive to Bone Marrow Transplantation After Expansion of Progenitors and Resumption of Blood Cell Production. PMID: 34414177

Immune evasion by oncogenic proteins of acute myeloid leukemia. PMID: 24449212

CD48 monoclonal antibody K31 for bone marrow transplantation. PMID: 1438442

Influence of breast cancer on thymic function in mice. PMID: 12463739

2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. PMID: 15607804

Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. PMID: 16569764

Identification Hub Genes in Colorectal Cancer by Integrating Weighted Gene Co-Expression Network Analysis and Clinical Validation in vivo and vitro. PMID: 32426282

Analysis of cell-adhesion molecule interactions using surface plasmon resonance. PMID: 8725949

Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells. PMID: 10577499

2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. PMID: 10658976

The structure and ligand interactions of CD2: implications for T-cell function. PMID: 8871350

sCD48 is anti-inflammatory in Staphylococcus aureus Enterotoxin B-induced eosinophilic inflammation. PMID: 26836239

Determination of the lifetime and force dependence of interactions of single bonds between surface-attached CD2 and CD48 adhesion molecules. PMID: 8986773

Parallels in T lymphocyte development between lpr and normal mice. PMID: 8167306

Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors. PMID: 11899233

Regulation of mast cell-mediated innate immunity during early response to bacterial infection. PMID: 11975423

NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice. PMID: 24610736

The dependence of the association rate of surface-attached adhesion molecules CD2 and CD48 on separation distance. PMID: 9091309

Dancing the immunological two-step. PMID: 10428718

Cell biology. Bacterial spelunkers. PMID: 10950716

Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. PMID: 12369898

The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation. PMID: 8104794

Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. PMID: 15634901

Antitumour activity of a chimeric antibody against the leucocyte antigen CD48. PMID: 10630312

Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2. PMID: 20813844

Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells. PMID: 28939491

A critical role for CD48 antigen in regulating alloengraftment and lymphohematopoietic recovery after bone marrow transplantation. PMID: 9834253

Eosinophils interaction with mast cells: the allergic effector unit. PMID: 24986621

The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. PMID: 1999350

Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations. PMID: 28390194

Increased expression of CD48 on neutrophils activated in childhood patients with aplastic anemia. PMID: 7534499

Mechanism of induction of NK activation by 2B4 (CD244) via its cognate ligand. PMID: 20881194

Macrophages lift off surface-bound bacteria using a filopodium-lamellipodium hook-and-shovel mechanism. PMID: 24097079

Characterisation of the low affinity interaction between rat cell adhesion molecules CD2 and CD48 by analytical ultracentrifugation. PMID: 9188168

Functional capability of IL-15-Akt signaling in the denervated muscle. PMID: 23017227

The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells. PMID: 22693613

Enhanced murine CD4+ T cell responses induced by the CD2 ligand CD48. PMID: 9862369

COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes. PMID: 34143756

Radiation-induced bystander effect in immune response. PMID: 15202863

Analysis of mutation in the rat Pig-a assay: II. Studies with bone marrow granulocytes. PMID: 30091248

Identification of a clonally expanding haematopoietic compartment in bone marrow. PMID: 23188081

Receptors and counterreceptors involved in NK-B cell interactions. PMID: 15778370

Further evidence for a gamma/delta T cell receptor-mediated TCT.1/CD48 recognition. PMID: 1655899

Clonal T cells of pure red-cell aplasia. PMID: 16044445

Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling. PMID: 24882704

Case Report: Flow cytometric differential diagnosis of a peripheral T-cell lymphoma, NOS with complete loss of CD45 and dim expression of CD3., PMID:40510503

SGSM1 as a pan-cancer biomarker: multi-omics insights into immune regulation, prognostic value, and therapeutic implications., PMID:40500484

Integrating bioinformatics and machine learning to identify glomerular injury genes and predict drug targets in diabetic nephropathy., PMID:40374840

SAMSN1 causes sepsis immunosuppression by inducing macrophages to express coinhibitory molecules that cause T-cell exhaustion via KEAP1-NRF2 signaling., PMID:40293473

Comprehensive pan-cancer analysis identifies PLAG1 as a key regulator of tumor immune microenvironment and prognostic biomarker., PMID:40276502

DNA methylation-predicted plasma protein levels and breast cancer risk., PMID:40140843

Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head., PMID:40102965

Sex differences alter primitive progenitors in the C57BL/6 Tet2 knockout mouse model., PMID:40015506

Functional study of tilapia T cell activation stimulus signal molecule CD2., PMID:39909121

Imaging of biphasic signalosomes constructed by checkpoint receptor 2B4 in conventional and chimeric antigen receptor-T cells., PMID:39886466

Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury., PMID:39814871

Urinary Immune Complexes Reflect Renal Pathology in Lupus Nephritis., PMID:39767148

Neutrophil Elastase Targets Select Proteins on Human Blood-Monocyte-Derived Macrophage Cell Surfaces., PMID:39684750

Deep phenotyping of T regulatory cells in psoriatic arthritis highlights targetable mechanisms of disease., PMID:39662827

Exploring diagnostic biomarkers of type 2 cardio-renal syndrome based on secreted proteins and bioinformatics analysis., PMID:39427047

High-Throughput Transcriptomics Identifies Chemoresistance-Associated Gene Expression Signatures in Human Angiosarcoma., PMID:39409192

In Situ Analyses of Placental Inflammatory Response to SARS-CoV-2 Infection in Cases of Mother-Fetus Vertical Transmission., PMID:39201511

Identification of gene and protein signatures associated with long-term effects of COVID-19 on the immune system after patient recovery by analyzing single-cell multi-omics data using a machine learning approach., PMID:39182316

Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration., PMID:38996072

CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation., PMID:38957433

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity., PMID:38896451

Identification of Immune Infiltrating Cell-Related Biomarkers in Early Gastric Cancer Progression., PMID:38860335

Exploring T-cell exhaustion features in Acute myocardial infarction for a Novel Diagnostic model and new therapeutic targets by bio-informatics and machine learning., PMID:38783198

Identification of potential biomarkers of leprosy: A study based on GEO datasets., PMID:38739634

Proteomics validate circulating GDF-15 as an independent biomarker for COVID-19 severity., PMID:38686386

Biomarker discovery with quantum neural networks: a case-study in CTLA4-activation pathways., PMID:38609844

Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia., PMID:38452334

HERVK-mediated regulation of neighboring genes: implications for breast cancer prognosis., PMID:38388382

Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48., PMID:38386559

A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution., PMID:38374174

Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma., PMID:38355622

Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma., PMID:38292661

The transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure., PMID:37978185

Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974

Exploring immune related gene signatures and mechanisms linking non alcoholic fatty liver disease to atrial fibrillation through transcriptome data analysis., PMID:37845390

Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice., PMID:37756546

FCGR2B as a prognostic and immune microenvironmental marker for gliomas based on transcriptomic analysis., PMID:37713871

Combination of CD49b and CD229 Reveals a Subset of Multipotent Progenitors With Short-Term Activity Within the Hematopoietic Stem Cell Compartment., PMID:37706539

2B4: A potential target in Staphylococcus aureus associated allergic inflammation., PMID:37583293

Involvement of KLRK1 in immune infiltration of head and neck squamous cell carcinoma correlates with favorable prognosis., PMID:37565867

2B4 inhibits the apoptosis of natural killer cells through phosphorylated extracellular signal-related kinase/B-cell lymphoma 2 signal pathway., PMID:37516949

Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity., PMID:37404017

Immune response of DNA vaccinated-gilthead seabream (Sparus aurata) against LCDV-Sa infection: relevance of the inflammatory process., PMID:37346045

CD48 suppresses proliferation and migration as an immune-related prognostic signature in the cervical cancer immune microenvironment., PMID:37279525

The hyperinflammatory spectrum: from defects in cytotoxicity to cytokine control., PMID:37187762

WGCNA and molecular docking identify hub genes for cardiac aging., PMID:37180776

Integrative analyses of biomarkers and pathways for diabetic nephropathy., PMID:37113991

Deep learning on graphs for multi-omics classification of COPD., PMID:37083575

Uncovering the Underworld of Axial Spondyloarthritis., PMID:37047435

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity., PMID:36891288

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human CD48 Protein, N-His [YHC39801]
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