Catalog No.
RHD74801
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000
Target
APX, APE1, APEX nuclease, APEN, Redox factor-1, APE-1, REF1, APEX, APE, Apurinic-apyrimidinic endonuclease 1, HAP1, AP endonuclease 1, APEX1, DNA-(apurinic or apyrimidinic site) endonuclease, REF-1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P27695
Applications
IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1T37
Divergent evolution of opposite base specificity and single-stranded DNA activity in animal and plant AP endonucleases., PMID:39778867
Expression of Apurinic/Apyrimidinic Endonuclease 1 in Colorectal Cancer and its Relation to Tumor Progression and Prognosis., PMID:37652525
Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown., PMID:33627408
Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions., PMID:32555206
Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus., PMID:31494269
An electrochemical biosensor integrating immunoassay and enzyme activity analysis for accurate detection of active human apurinic/apyrimidinic endonuclease 1., PMID:31387027
The extracellular role of Ref-1 as anti-inflammatory function in lipopolysaccharide-induced septic mice., PMID:31100475
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination., PMID:30705092
Metal-Ion-Responsive Bionanocomposite for Selective and Reversible Enzyme Inhibition., PMID:30484642
Unusual interaction of human apurinic/apyrimidinic endonuclease 1 (APE1) with abasic sites via the Schiff-base-dependent mechanism., PMID:29730300
Clinical value of combined detection of serum APE1-Aabs and CEACAM-1 in the diagnosis of colorectal cancer., PMID:29565485
SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA Repair., PMID:28689995
Clinical implications of APEX1 and Jagged1 as chemoresistance factors in biliary tract cancer., PMID:28090501
Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen., PMID:27560983
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses., PMID:27637330
DNA Methylation Leads to DNA Repair Gene Down-Regulation and Trinucleotide Repeat Expansion in Patient-Derived Huntington Disease Cells., PMID:27182645
Secreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor., PMID:26964514
Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia., PMID:26761793
A novel method for monitoring functional lesion-specific recruitment of repair proteins in live cells., PMID:25879709
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination., PMID:25404348
Signal-on electrochemical immunoassay for APE1 using ionic liquid doped Au nanoparticle/graphene as a nanocarrier and alkaline phosphatase as enhancer., PMID:25356934
Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity., PMID:24970265
Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation., PMID:24927551
The changes of 8-OHdG, hOGG1, APE1 and Pol β in lenses of patients with age-related cataract., PMID:24911554
Growth hormone protects colorectal cancer cells from radiation by improving the ability of DNA damage repair., PMID:24788673
The binding of silibinin to ERp57., PMID:24530445
Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex., PMID:24328308
You break it, you fix it: functions for AID downstream of deamination., PMID:24145783
Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance., PMID:24127576
A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination., PMID:24097111
Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancer., PMID:23472128
The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos., PMID:23154201
Ultrasensitive electrochemical strategy for trace detection of APE-1 via triple signal amplification strategy., PMID:22981009
Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers., PMID:22713458
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil., PMID:22483865
Antifungal miconazole induces cardiotoxicity via inhibition of APE/Ref-1-related pathway in rat neonatal cardiomyocytes., PMID:22262564
Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches., PMID:21474795
Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer., PMID:21325978
Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice., PMID:21321532
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions., PMID:21151102
Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death., PMID:20637286
APE1/Ref-1 in Alzheimer's disease: an immunohistochemical study., PMID:19782121
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA., PMID:19401441
[Preparation and characterization of rabbit anti-human apurinic/apyrimidinic endonuclease(APE1) polyclonal antibody]., PMID:19351502
The SET complex acts as a barrier to autointegration of HIV-1., PMID:19266025
Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells., PMID:19101986
The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch., PMID:19010771
Long patch base excision repair in mammalian mitochondrial genomes., PMID:18635552
Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats., PMID:18253720
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination., PMID:18025127
For research use only. Not for human or drug use.
