Catalog No.
RHD71201
Species reactivity
Human, Mouse, Rat, Hamster
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
HMGB2, High mobility group protein 2, HMG-2, HMG2, High mobility group protein B2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P26583
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1T10
Note
For research use only.
High mobility group proteins of amphibian oocytes: a large storage pool of a soluble high mobility group-1-like protein and involvement in transcriptional events., PMID:6224801
Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line., PMID:2423348
[Comparison of the antigenic properties of the HMG proteins composing the chromatin of tissues differing in levels of transcription activity]., PMID:2431563
Studies on the stability of the higher-order structure of rat liver chromatin containing high-mobility-group proteins., PMID:3816809
Autoantibodies to nonhistone chromosomal proteins HMG-1 and HMG-2 in sera of patients with juvenile rheumatoid arthritis., PMID:2403401
[Effect of HMG proteins and their phosphorylated forms on the process of transcription in neuronal nuclei of the rat brain (data from an immunochemical analysis)]., PMID:1525238
Molecular cloning of chick liver HMG 2a cDNA and developmental expression of HMG 2a mRNA., PMID:1562600
HMG-2 protein in developing rat brain cells., PMID:8432381
Antibodies to HMG proteins in patients with drug-induced autoimmunity., PMID:7907477
Repression of basal transcription by HMG2 is counteracted by TFIIH-associated factors in an ATP-dependent process., PMID:8007973
Antibodies to high mobility group proteins in systemic sclerosis., PMID:7869312
Identification of cDNA clones encoding HMG 2, a major protein of the mexican axolotl hydrocortisone-sensitive thymocytes., PMID:8654668
Intracellular distribution of HMG1, HMG2 and UBF change following treatment with cisplatin., PMID:8679707
Primary pulmonary hypertension: immunogenetic response to high-mobility group (HMG) proteins and histone., PMID:8918589
Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2., PMID:9010268
RAGged repair: what's new in V(D)J recombination., PMID:9377476
Antibodies against a peptide sequence located in the linker region of the HMG-1/2 box domains in sera from patients with juvenile rheumatoid arthritis., PMID:9336414
Prevalence and characterization of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) directed against HMG1 and HMG2 in ulcerative colitis (UC)., PMID:9486411
Prevalence and characterization of novel pANCA, antibodies to the high mobility group non-histone chromosomal proteins HMG1 and HMG2, in systemic rheumatic diseases., PMID:9558172
High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro., PMID:9722660
[High mobility group protein HMG1/HMG2: clinical significance of the autoantibodies]., PMID:9867410
High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis., PMID:10323891
Alteration of protein composition in mouse thymocytes by signals through T-cell receptor., PMID:10870970
Relationship between sex and antibodies to high mobility group proteins 1 and 2 in juvenile idiopathic arthritis., PMID:11036848
Detection of anti-neutrophil cytoplasmic antibodies in MRL/Mp-lpr/lpr mice and analysis of their target antigens., PMID:11191287
Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain., PMID:11279268
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation., PMID:11756557
Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases., PMID:12473246
High mobility group protein 1 (HMGB1) quantified by ELISA with a monoclonal antibody that does not cross-react with HMGB2., PMID:12928240
The interaction of the estrogen receptor with mononucleosomes., PMID:15062546
Contributions of high mobility group box protein in experimental and clinical acute lung injury., PMID:15374839
Conformational difference in HMGB1 proteins of human neutrophils and lymphocytes revealed by epitope mapping of a monoclonal antibody., PMID:15496585
RAG1/2 re-expression causes receptor revision in a model B cell line., PMID:16701898
New high mobility group box 1 assay system., PMID:16797518
Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a transport protein involved in gene-specific mRNA export and protein translation during spermatogenesis., PMID:16968703
HMGB1, a novel inflammatory cytokine., PMID:16979611
High mobility group box (HMGB) proteins of Plasmodium falciparum: DNA binding proteins with pro-inflammatory activity., PMID:18234548
Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage., PMID:19372559
Anti-high mobility group box 1 and box 2 non-histone chromosomal proteins (HMGB1/HMGB2) antibodies and anti-Saccharomyces cerevisiae antibodies (ASCA): accuracy in differentially diagnosing UC and CD and correlation with inflammatory bowel disease phenotype., PMID:22644337
The combination of a nuclear HMGB1-positive and HMGB2-negative expression is potentially associated with a shortened survival in patients with pancreatic ductal adenocarcinoma., PMID:25060178
Cross-reactivity of anti-HMGB1 antibodies for HMGB2., PMID:29453955
Emergence of antibodies endowed with proteolytic activity against High-mobility group box 1 protein (HMGB1) in patients surviving septic shock., PMID:31767118
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung., PMID:33731112
The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis., PMID:35525959
Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974
The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy., PMID:38622929
HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia., PMID:39829613
Myeloid-Driven Immune Suppression Subverts Neutralizing Antibodies and T Cell Immunity in Severe COVID-19., PMID:40183283
Targeting HMGB2 acts as dual immunomodulator by bolstering CD8+ T cell function and inhibiting tumor growth in hepatocellular carcinoma., PMID:40315321
Circulating HMGB2 Is Associated With Angiographic Coronary Collateralization in Diabetic Patients With Chronic Total Occlusion and Impairs Vessel Growth via NLRP3., PMID:40368806
For research use only. Not for human or drug use.
