Catalog No.
RHD71202
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
HMGB2, High mobility group protein 2, HMG-2, HMG2, High mobility group protein B2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P26583
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1T09
Circulating HMGB2 Is Associated With Angiographic Coronary Collateralization in Diabetic Patients With Chronic Total Occlusion and Impairs Vessel Growth via NLRP3., PMID:40368806
Targeting HMGB2 acts as dual immunomodulator by bolstering CD8+ T cell function and inhibiting tumor growth in hepatocellular carcinoma., PMID:40315321
Myeloid-Driven Immune Suppression Subverts Neutralizing Antibodies and T Cell Immunity in Severe COVID-19., PMID:40183283
HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia., PMID:39829613
The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy., PMID:38622929
Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974
The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis., PMID:35525959
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung., PMID:33731112
Emergence of antibodies endowed with proteolytic activity against High-mobility group box 1 protein (HMGB1) in patients surviving septic shock., PMID:31767118
Cross-reactivity of anti-HMGB1 antibodies for HMGB2., PMID:29453955
The combination of a nuclear HMGB1-positive and HMGB2-negative expression is potentially associated with a shortened survival in patients with pancreatic ductal adenocarcinoma., PMID:25060178
Anti-high mobility group box 1 and box 2 non-histone chromosomal proteins (HMGB1/HMGB2) antibodies and anti-Saccharomyces cerevisiae antibodies (ASCA): accuracy in differentially diagnosing UC and CD and correlation with inflammatory bowel disease phenotype., PMID:22644337
Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage., PMID:19372559
High mobility group box (HMGB) proteins of Plasmodium falciparum: DNA binding proteins with pro-inflammatory activity., PMID:18234548
HMGB1, a novel inflammatory cytokine., PMID:16979611
Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a transport protein involved in gene-specific mRNA export and protein translation during spermatogenesis., PMID:16968703
New high mobility group box 1 assay system., PMID:16797518
RAG1/2 re-expression causes receptor revision in a model B cell line., PMID:16701898
Conformational difference in HMGB1 proteins of human neutrophils and lymphocytes revealed by epitope mapping of a monoclonal antibody., PMID:15496585
Contributions of high mobility group box protein in experimental and clinical acute lung injury., PMID:15374839
The interaction of the estrogen receptor with mononucleosomes., PMID:15062546
High mobility group protein 1 (HMGB1) quantified by ELISA with a monoclonal antibody that does not cross-react with HMGB2., PMID:12928240
Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases., PMID:12473246
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation., PMID:11756557
Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain., PMID:11279268
Detection of anti-neutrophil cytoplasmic antibodies in MRL/Mp-lpr/lpr mice and analysis of their target antigens., PMID:11191287
Relationship between sex and antibodies to high mobility group proteins 1 and 2 in juvenile idiopathic arthritis., PMID:11036848
Alteration of protein composition in mouse thymocytes by signals through T-cell receptor., PMID:10870970
High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis., PMID:10323891
[High mobility group protein HMG1/HMG2: clinical significance of the autoantibodies]., PMID:9867410
High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro., PMID:9722660
Prevalence and characterization of novel pANCA, antibodies to the high mobility group non-histone chromosomal proteins HMG1 and HMG2, in systemic rheumatic diseases., PMID:9558172
Prevalence and characterization of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) directed against HMG1 and HMG2 in ulcerative colitis (UC)., PMID:9486411
Antibodies against a peptide sequence located in the linker region of the HMG-1/2 box domains in sera from patients with juvenile rheumatoid arthritis., PMID:9336414
RAGged repair: what's new in V(D)J recombination., PMID:9377476
Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2., PMID:9010268
Primary pulmonary hypertension: immunogenetic response to high-mobility group (HMG) proteins and histone., PMID:8918589
Intracellular distribution of HMG1, HMG2 and UBF change following treatment with cisplatin., PMID:8679707
Identification of cDNA clones encoding HMG 2, a major protein of the mexican axolotl hydrocortisone-sensitive thymocytes., PMID:8654668
Antibodies to high mobility group proteins in systemic sclerosis., PMID:7869312
Repression of basal transcription by HMG2 is counteracted by TFIIH-associated factors in an ATP-dependent process., PMID:8007973
Antibodies to HMG proteins in patients with drug-induced autoimmunity., PMID:7907477
HMG-2 protein in developing rat brain cells., PMID:8432381
Molecular cloning of chick liver HMG 2a cDNA and developmental expression of HMG 2a mRNA., PMID:1562600
[Effect of HMG proteins and their phosphorylated forms on the process of transcription in neuronal nuclei of the rat brain (data from an immunochemical analysis)]., PMID:1525238
Autoantibodies to nonhistone chromosomal proteins HMG-1 and HMG-2 in sera of patients with juvenile rheumatoid arthritis., PMID:2403401
Studies on the stability of the higher-order structure of rat liver chromatin containing high-mobility-group proteins., PMID:3816809
[Comparison of the antigenic properties of the HMG proteins composing the chromatin of tissues differing in levels of transcription activity]., PMID:2431563
Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line., PMID:2423348
High mobility group proteins of amphibian oocytes: a large storage pool of a soluble high mobility group-1-like protein and involvement in transcriptional events., PMID:6224801
For research use only. Not for human or drug use.
