Anti-TFEB Antibody (R1R24)

Catalog No.

RHD34401

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000

Target

TFEB, Class E basic helix-loop-helix protein 35, BHLHE35, bHLHe35, Transcription factor EB

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P19484

Applications

IF, IHC, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1R24

Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity., PMID:39956805

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis., PMID:39806423

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness., PMID:39580479

Platinum-Metformin Conjugates Acting as Promising PD-L1 Inhibitors through the AMP-Activated Protein Kinase Mediated Lysosomal Degradation Pathway., PMID:39206686

Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity., PMID:39196068

TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions., PMID:39138218

PRRSV utilizes MALT1-regulated autophagy flux to switch virus spread and reserve., PMID:39081059

Rag-GTPase-TFEB/TFE3 axis controls B cell mitochondrial fitness and humoral immunity independent of mTORC1., PMID:38585731

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness., PMID:38463988

Melanotic PEComa: A Rare But Distinctive Subtype Analyzed in a Series of 7 Cases., PMID:38117287

STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages., PMID:37554436

High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma., PMID:37095531

EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy., PMID:36788350

Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity., PMID:36759727

Obesity accelerates immune evasion of non-small cell lung carcinoma via TFEB-dependent upregulation of Siglec-15 and glycolytic reprogramming., PMID:36150633

Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance., PMID:35882754

Protocols to monitor TFEB activation following lysosomal damage in cultured cells using microscopy and immunoblotting., PMID:35243365

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations., PMID:34521933

LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells., PMID:34313548

Loss of PIKfyve drives the spongiform degeneration in prion diseases., PMID:34291577

CREG1 promotes lysosomal biogenesis and function., PMID:33966596

Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response., PMID:33706671

20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes., PMID:33460793

TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS., PMID:33300868

TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1., PMID:33208882

Arsenic induces mTOR-dependent autophagy, whereas it impairs the autophagy-lysosome pathway and the potential role of TFEB in cultured dendritic cells., PMID:32519707

Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models., PMID:32128386

Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model., PMID:31911786

Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet., PMID:31515484

TNF-α Suppresses Autophagic Flux in Acinar Cells in IgG4-Related Sialadenitis., PMID:31461632

Nutrient deprivation and lysosomal stress induce activation of TFEB in retinal pigment epithelial cells., PMID:31160892

SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions., PMID:30774023

The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts., PMID:30620384

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3]., PMID:30107660

Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome., PMID:28700687

Xp11 Translocation Renal Cell Carcinomas (RCCs) With RBM10-TFE3 Gene Fusion Demonstrating Melanotic Features and Overlapping Morphology With t(6;11) RCC: Interest and Diagnostic Pitfall in Detecting a Paracentric Inversion of TFE3., PMID:28288037

PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism., PMID:28275133

Methods to Monitor and Manipulate TFEB Activity During Autophagy., PMID:28237119

Proximal CD13 Versus Distal GATA-3 Expression in Renal Neoplasia According to WHO 2016 Classification., PMID:27556823

Oncotargets in different renal cancer subtypes., PMID:25619751

Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm., PMID:25138534

Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development., PMID:24764321

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases., PMID:24081491

Renal tumors: diagnostic and prognostic biomarkers., PMID:24025522

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice., PMID:23830905

Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein., PMID:22927642

Renal translocation carcinoma with expression of TFEB: presentation of a case with distinctive histological and immunohistochemical features., PMID:19687027

Renal translocation carcinomas: clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature., PMID:18344867

Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation., PMID:17705868

Xp11.2 translocation renal cell carcinoma with very aggressive course in five adults., PMID:17580272

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