Catalog No.
RHD22501
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
HMGA1, High mobility group protein HMG-I/HMG-Y, High mobility group protein A1, HMGIY, High mobility group protein R, HMG-I(Y), High mobility group AT-hook protein 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P17096
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1Q26
Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies., PMID:40240912
BANCR-containing extracellular vesicles enhance breast cancer resistance., PMID:39947472
HMGA1 influence on iron-induced cell death in Tfh cells of SLE patients., PMID:39707065
A three-gene expression score for predicting clinical benefit to anti-PD-1 blockade in advanced renal cell carcinoma., PMID:38660294
The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy., PMID:38622929
Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 0 (ICP0) Targets of Ubiquitination during Productive Infection of Primary Adult Sensory Neurons., PMID:36769256
Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management., PMID:35221836
Yangonin inhibits ethanol-induced hepatocyte senescence via miR-194/FXR axis., PMID:33068587
Clinical Implications of Extracellular HMGA1 in Breast Cancer., PMID:31779212
PD-L1 promotes colorectal cancer stem cell expansion by activating HMGA1-dependent signaling pathways., PMID:30776481
Setting up and exploitation of a nano/technological platform for the evaluation of HMGA1b protein in peripheral blood of cancer patients., PMID:30308301
Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer., PMID:30135148
The HMGA gene family in chordates: evolutionary perspectives from amphioxus., PMID:28474175
Analysis of Ki67, HMGA1, MDM2, and RB expression in nonfunctioning pituitary adenomas., PMID:28255749
PKCε as a novel promoter of skeletal muscle differentiation and regeneration., PMID:26431586
Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes., PMID:26009897
HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels., PMID:24833610
Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: an overview., PMID:23359388
Comparative analysis of immunohistochemical markers for differential diagnosis of hepatocelluar carcinoma and cholangiocarcinoma., PMID:23052165
Hmga1 is differentially expressed and mediates silencing of the CD4/CD8 loci in T cell lineages and leukemic cells., PMID:22106824
New prognostic markers and potential therapeutic targets in human testicular germ cell tumors., PMID:22050751
Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention., PMID:19787257
High mobility group HMGI(Y) protein expression in head and neck squamous cell carcinoma., PMID:17364334
Expression of the high-mobility group protein HMGI(Y) in gestational trophoblastic diseases., PMID:16306787
Identification of an NF-Y/HMG-I(Y)-binding site in the human IL-10 promoter., PMID:16256199
HMGA1 protein expression sensitizes cells to cisplatin-induced cell death., PMID:16007157
Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity., PMID:15249855
High mobility group A1 is expressed in metastatic adenocarcinoma to the liver and intrahepatic cholangiocarcinoma, but not in hepatocellular carcinoma: its potential use in the diagnosis of liver neoplasms., PMID:14714251
HMGA1 co-activates transcription in B cells through indirect association with DNA., PMID:12907668
Analysis of pea HMG-I/Y expression suggests a role in defence gene regulation., PMID:20569385
The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes., PMID:12663813
An intron enhancer activates the immunoglobulin-related Hemolin gene in Hyalophora cecropia., PMID:12230549
Diagnostic significance of high mobility group I(Y) protein expression in intraductal papillary mucinous tumors of the pancreas., PMID:12142746
HMGA1 and HMGA2 protein expression in mouse spermatogenesis., PMID:12032866
Dominant-negative HMGA1 blocks mu enhancer activation through a novel mechanism., PMID:11906180
HMGA1 enhances the transcriptional activity and binding of the estrogen receptor to its responsive element., PMID:11851423
Further considerations on the intranuclear distribution of HMGI/Y proteins., PMID:11767201
Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins., PMID:10866296
Induction of early transcription in one-cell mouse embryos by microinjection of the nonhistone chromosomal protein HMG-I., PMID:10790330
Characterization of a novel cdk1-related kinase., PMID:10447673
Three distinct sub-nuclear populations of HMG-I protein of different properties revealed by co-localization image analysis., PMID:9811569
Intranuclear distribution of HMGI/Y proteins. An immunocytochemical study., PMID:9632746
An HMG-I protein from human endothelial cells apparently is secreted and impairs activation of Hageman factor (factor XII)., PMID:9542770
Prevalence and characterization of novel pANCA, antibodies to the high mobility group non-histone chromosomal proteins HMG1 and HMG2, in systemic rheumatic diseases., PMID:9558172
Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervix., PMID:9458084
Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression., PMID:9365113
Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations., PMID:9212729
HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro., PMID:9038339
Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2., PMID:9010268
Independent pathways for de-repression of the mouse Ig heavy chain germ-line epsilon promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element., PMID:8757943
For research use only. Not for human or drug use.
