Catalog No.
RHC93503
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
Fc-gamma RII-a, IgG Fc receptor II-a, IGFR2, FCG2, CDw32, FCGR2A1, FCGR2A, FcRII-a, CD32, Low affinity immunoglobulin gamma Fc region receptor II-a, Fc-gamma-RIIa
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P12318, P31994, P31995
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1N68
Note
For research use only.
Fcγ Receptor IIa (FCGR2A) Polymorphism Is Associated With Severe Respiratory Syncytial Virus Disease in Argentinian Infants., PMID:33392111
Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB., PMID:33424858
Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT): Targeting Pathomechanisms with Bruton Tyrosine Kinase Inhibitors., PMID:33851389
G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment., PMID:34049929
Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques., PMID:34093580
Procoagulant microparticles: a possible link between vaccine-induced immune thrombocytopenia (VITT) and cerebral sinus venous thrombosis., PMID:34129181
Immunomodulation: Immunoglobulin Preparations Suppress Hyperinflammation in a COVID-19 Model via FcγRIIA and FcαRI., PMID:34177967
Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients., PMID:34205175
CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues., PMID:34220857
Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia., PMID:34233346
Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival., PMID:34497614
Development of a novel reporter gene assay to evaluate antibody-dependent cellular phagocytosis for anti-CD20 therapeutic antibodies., PMID:34521023
Platelet FcγRIIA-induced serotonin release exacerbates the severity of transfusion-related acute lung injury in mice., PMID:34521102
Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children., PMID:34551786
HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function., PMID:34566999
An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability., PMID:34687301
Fc fragment of immunoglobulin G receptor IIa (FCGR2A) as a new potential prognostic biomarker of esophageal squamous cell carcinoma., PMID:34743150
Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease., PMID:34970970
Role of Fcγ receptors in HER2-targeted breast cancer therapy., PMID:34992090
ACE2 can act as the secondary receptor in the FcγR-dependent ADE of SARS-CoV-2 infection., PMID:35005526
Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton's Tyrosine Kinase., PMID:35008508
SAR442085, a novel anti-CD38 antibody with enhanced antitumor activity against multiple myeloma., PMID:35201323
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19., PMID:35309299
Cell-based reporter assays for measurements of antibody-mediated cellular cytotoxicity and phagocytosis against SARS-CoV-2 spike protein., PMID:35671888
Impact of FCGR2A R131H, FCGR3A F158V and FCGR3B NA1/NA2 polymorphisms on response to Fc-containing TNF inhibitors in Tunisian rheumatoid arthritis patients., PMID:36919284
Mass cytometry for the multiplexed quantification and characterization of target expression on circulating cells in whole blood., PMID:36966446
FcγRIIA-specific DARPins as novel tools in blood cell analysis and platelet aggregation., PMID:37100283
Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis., PMID:37114884
Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis., PMID:37149714
Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy., PMID:37250170
Vaccine-induced immune thrombotic thrombocytopenia: what do we know hitherto?, PMID:37261122
Antimyeloperoxidase antibodies modulate inflammatory responses and activate profibrotic pathways in human monocytes., PMID:37331172
T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity., PMID:37436890
FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab., PMID:37575254
Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology., PMID:37703311
Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes., PMID:37790943
Macrophage N-glycan processing inhibits antibody-dependent cellular phagocytosis., PMID:37792857
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia., PMID:37872381
Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors., PMID:38077405
Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro., PMID:38455048
Immunoglobulin genes and severity of COVID-19., PMID:38602517
Druggability properties of a L309K mutation in the antibody CH2 domain., PMID:38742229
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics., PMID:38798354
Suppressing anti-citrullinated protein antibody-induced osteoclastogenesis in rheumatoid arthritis using anti-CD64 and PAD-2 inhibitors., PMID:39152765
FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms., PMID:39359734
Impact of FCGR2A rs1801274 and IL-6R rs2228145 polymorphisms on tocilizumab response in the Iranian population with severe COVID-19., PMID:39415081
Roles of immunoglobulin GM and KM allotypes and Fcγ receptor 2 A genotypes in humoral immunity to a conserved microbial polysaccharide in pulmonary diseases., PMID:39774260
Construction and characterization of chimeric FcγR T cells for universal T cell therapy., PMID:39810257
Structural and functional changes underlying activation of monocytes in heparin-induced thrombocytopenia., PMID:39933652
Human Fcγ-receptors selectively respond to C-reactive protein isoforms., PMID:40458392
For research use only. Not for human or drug use.
