Catalog No.
RHC93503
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
Fc-gamma RII-a, IgG Fc receptor II-a, IGFR2, FCG2, CDw32, FCGR2A1, FCGR2A, FcRII-a, CD32, Low affinity immunoglobulin gamma Fc region receptor II-a, Fc-gamma-RIIa
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P12318, P31994, P31995
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1N68
Human Fcγ-receptors selectively respond to C-reactive protein isoforms., PMID:40458392
Structural and functional changes underlying activation of monocytes in heparin-induced thrombocytopenia., PMID:39933652
Construction and characterization of chimeric FcγR T cells for universal T cell therapy., PMID:39810257
Roles of immunoglobulin GM and KM allotypes and Fcγ receptor 2 A genotypes in humoral immunity to a conserved microbial polysaccharide in pulmonary diseases., PMID:39774260
Impact of FCGR2A rs1801274 and IL-6R rs2228145 polymorphisms on tocilizumab response in the Iranian population with severe COVID-19., PMID:39415081
FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms., PMID:39359734
Suppressing anti-citrullinated protein antibody-induced osteoclastogenesis in rheumatoid arthritis using anti-CD64 and PAD-2 inhibitors., PMID:39152765
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics., PMID:38798354
Druggability properties of a L309K mutation in the antibody CH2 domain., PMID:38742229
Immunoglobulin genes and severity of COVID-19., PMID:38602517
Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro., PMID:38455048
Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors., PMID:38077405
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia., PMID:37872381
Macrophage N-glycan processing inhibits antibody-dependent cellular phagocytosis., PMID:37792857
Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes., PMID:37790943
Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology., PMID:37703311
FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab., PMID:37575254
T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity., PMID:37436890
Antimyeloperoxidase antibodies modulate inflammatory responses and activate profibrotic pathways in human monocytes., PMID:37331172
Vaccine-induced immune thrombotic thrombocytopenia: what do we know hitherto?, PMID:37261122
Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy., PMID:37250170
Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis., PMID:37149714
Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis., PMID:37114884
FcγRIIA-specific DARPins as novel tools in blood cell analysis and platelet aggregation., PMID:37100283
Mass cytometry for the multiplexed quantification and characterization of target expression on circulating cells in whole blood., PMID:36966446
Impact of FCGR2A R131H, FCGR3A F158V and FCGR3B NA1/NA2 polymorphisms on response to Fc-containing TNF inhibitors in Tunisian rheumatoid arthritis patients., PMID:36919284
Cell-based reporter assays for measurements of antibody-mediated cellular cytotoxicity and phagocytosis against SARS-CoV-2 spike protein., PMID:35671888
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19., PMID:35309299
SAR442085, a novel anti-CD38 antibody with enhanced antitumor activity against multiple myeloma., PMID:35201323
Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton's Tyrosine Kinase., PMID:35008508
ACE2 can act as the secondary receptor in the FcγR-dependent ADE of SARS-CoV-2 infection., PMID:35005526
Role of Fcγ receptors in HER2-targeted breast cancer therapy., PMID:34992090
Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease., PMID:34970970
Fc fragment of immunoglobulin G receptor IIa (FCGR2A) as a new potential prognostic biomarker of esophageal squamous cell carcinoma., PMID:34743150
An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability., PMID:34687301
HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function., PMID:34566999
Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children., PMID:34551786
Platelet FcγRIIA-induced serotonin release exacerbates the severity of transfusion-related acute lung injury in mice., PMID:34521102
Development of a novel reporter gene assay to evaluate antibody-dependent cellular phagocytosis for anti-CD20 therapeutic antibodies., PMID:34521023
Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival., PMID:34497614
Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia., PMID:34233346
CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues., PMID:34220857
Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients., PMID:34205175
Immunomodulation: Immunoglobulin Preparations Suppress Hyperinflammation in a COVID-19 Model via FcγRIIA and FcαRI., PMID:34177967
Procoagulant microparticles: a possible link between vaccine-induced immune thrombocytopenia (VITT) and cerebral sinus venous thrombosis., PMID:34129181
Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques., PMID:34093580
G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment., PMID:34049929
Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT): Targeting Pathomechanisms with Bruton Tyrosine Kinase Inhibitors., PMID:33851389
Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB., PMID:33424858
Fcγ Receptor IIa (FCGR2A) Polymorphism Is Associated With Severe Respiratory Syncytial Virus Disease in Argentinian Infants., PMID:33392111
For research use only. Not for human or drug use.
