Catalog No.
RHC92801
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
IMPDH-II, IMPD 2, IMPD2, IMPDH2, IMPDH 2, Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P12268
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1N60
Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer., PMID:38302471
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling., PMID:36177032
A recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer., PMID:35416106
Acute severe autoimmune hepatitis with anti-rods and rings autoantibodies; literature first evidence., PMID:33868616
Relationship between circulating tumor-associated autoantibodies and clinical outcomes in advanced-stage NSCLC patients receiving PD-1/-L1 directed immune checkpoint inhibition., PMID:33434603
Anti-rod and ring antibodies in patients with chronic hepatitis C using direct-acting antivirals., PMID:32537670
IMP dehydrogenase rod/ring structures in acral melanomas., PMID:31883196
Autoantibodies to cytoplasmic rods and rings in patients with hepatitis C virus infection treated with direct-acting antivirals: The role of prior treatment with interferon plus ribavirin., PMID:30446175
Autoantibodies against "rods and rings"-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a "real life" cohort., PMID:28815296
Prospective evaluation of 64 serum autoantibodies as biomarkers for early detection of colorectal cancer in a true screening setting., PMID:26909861
Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-α/ribavirin therapy., PMID:26877604
Anti-rods/rings: a human model of drug-induced autoantibody generation., PMID:25699057
Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures., PMID:25601894
Induction of cytoplasmic pattern in the form of "rods and rings" through the treatment of hepatitis C: a case report., PMID:25476473
Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α., PMID:24845459
Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection., PMID:23506439
Development of a recombinant cell-based indirect immunofluorescence assay (RC-IFA) for the determination of autoantibodies against "rings and rods"-associated inosine-5'-monophosphate dehydrogenase 2 in viral hepatitis C., PMID:23333419
Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients., PMID:23100146
Autoantibodies against inosine-5'-monophosphate dehydrogenase 2--characteristics and prevalence in patients with HCV-infection., PMID:22029192
Lymphocyte counts in kidney allograft recipients are associated with IMPDH2 3757T>C gene polymorphism., PMID:21996196
Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis., PMID:19597826
Mycophenolic acid inhibits oleic acid-induced mesangial cell activation through both cellular reactive oxygen species and inosine monophosphate dehydrogenase 2 pathways., PMID:19093139
For research use only. Not for human or drug use.
