Catalog No.
YHC32101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile30-Gln247
Predicted molecular weight
50.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08246
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Medullasin, ELA2, ELANE, PMN elastase, Neutrophil elastase, HLE, Human leukocyte elastase, Elastase-2, Bone marrow serine protease
NAT10 inhibits the pyroptosis of laryngeal squamous cell carcinoma through ac4C modification of ELANE mRNA., PMID:40448263
Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia., PMID:40260377
Identification and validation of pyroptosis patterns in AML via comprehensive bioinformatics analysis., PMID:40208371
ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease., PMID:40204709
Downregulation of tropomyosin 2 promotes the progression of lung adenocarcinoma by regulating neutrophil infiltration through neutrophil elastase., PMID:40199876
Tetrahedral DNA-Enhanced Interparticle Rolling Machine for High-Efficiency Human Neutrophil Elastase SERS Ratiometric Sensing in Serum and Tissue., PMID:40047041
Alterations in neutrophil mRNA profiles in multiple sclerosis and identification of candidate genes for further investigation., PMID:40035034
Correlation between REDOX enzymes and NET markers expression during the development of periapical lesions in mice., PMID:40024980
Caspase-12 exhibits non-redundant functions in response to endoplasmic reticulum stress to promote GSDMD-mediated NETosis, leading to thoracic aortic dissection., PMID:40015601
Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies., PMID:39975544
Evaluation of Neutrophil Elastase Inhibitors as Potential Therapies for ELANE Associated Neutropenia., PMID:39867870
Identification, Clinical Values, and Prospective Pathway Signaling of Lipid Metabolism Genes in Epilepsy and AED Treatment., PMID:39812994
The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure., PMID:39788946
Identification and Validation of Potential Biomarkers and Therapeutic Targets of COVID-19-related Depression., PMID:39781723
Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface., PMID:39777987
Down-regulation of SHP2 promotes neutrophil autophagy and inhibits neutrophil extracellular trap formation to alleviate asthma through the ERK5 pathway., PMID:39720267
CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis., PMID:39707013
Neutrophil Elastase Targets Select Proteins on Human Blood-Monocyte-Derived Macrophage Cell Surfaces., PMID:39684750
Case report: A cyclic neutropenia patient with ELANE mutation accompanied by hemophagocytic lymphohistiocytosis., PMID:39676859
The impact of genetic polymorphism on course and severity of the SARS-CoV-2 infection and COVID-19 disease., PMID:39660715
Integrative bioinformatics analysis of immune activation and gene networks in pediatric septic arthritis., PMID:39631225
Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties., PMID:39604162
G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing truncated-neutrophil elastase aggregates., PMID:39560992
DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2+ breast cancer., PMID:39542653
Neutrophil Elastase, Neuron-Specific Enolase, and S100B Protein as Potential Markers of Long-Term Complications Caused by COVID-19 in Patients with Type 2 Diabetes Mellitus (T2DM) and Advanced Stage of Diabetic Nephropathy (NfT2DM)-Observational Studies., PMID:39519343
Increased Lipocalin 2 detected by RNA sequencing regulates apoptosis and ferroptosis in COPD., PMID:39462322
Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice., PMID:39442524
Meta-Analysis and DIA-MS-Based Proteomic Investigation of COPD Patients and Asymptomatic Smokers in the Indian Population., PMID:39436829
Comparison of Gene-Editing Approaches for Severe Congenital Neutropenia-Causing Mutations in the ELANE Gene., PMID:39436283
Simplified Lipid Nanoparticles for Tissue- And Cell-Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model., PMID:39390844
Relationship between fat embolism and endothelial glycocalyx., PMID:39383615
Behçet's disease modifies the gingival inflammatory response., PMID:39295442
Genetic causes of primary immunodeficiency in the Jordanian population., PMID:39268404
Robustaflavone as a novel scaffold for inhibitors of native and auto-proteolysed human neutrophil elastase., PMID:39246138
Identifying Key Genes and Their Associated Molecular Pathways in Lupus Nephritis-Osteoporosis: An In-Silico Analysis., PMID:39213724
De Novo Deep Intron ELANE Mutation Resulting in Severe Congenital Neutropenia., PMID:39172268
Exploration of novel human neutrophil elastase inhibitors from natural compounds: Virtual screening, in vitro, molecular dynamics simulation and in vivo study., PMID:39159715
Pinhão potential and their parts (failures, shells, and almonds) in the elaboration of yogurts containing acai pulp: physicochemical, nutritional, and functional properties, antimicrobial activity, and multi-elemental profile., PMID:39147507
ELANE is a promising prognostic biomarker that mediates pyroptosis in gastric cancer., PMID:39130462
Human Neutrophil Elastase: Characterization of Intra- vs. Extracellular Inhibition., PMID:39063160
Integrative genomic analysis reveals cancer-associated mutations in patients with ophthalmic tumors., PMID:39053449
Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial., PMID:39048549
[Sivelestat sodium inhibits neutrophil elastase to regulate intrahepatic biliary mucin 5AC expression]., PMID:38991960
Transcriptome analysis reveals hepatic disordered lipid metabolism, lipotoxic injury, and abnormal development in IUGR sheep fetuses due to maternal undernutrition during late pregnancy., PMID:38968678
Bioinformatics analysis of key genes, immune infiltration, and risk assessment in low bone mineral density among perimenopausal women: An observational study., PMID:38968517
Elastin-derived peptides (EDPs) as a potential pro-malignancy factor in human leukemia cell lines., PMID:38967692
Proteomics analysis of deep fascia in acute compartment syndrome., PMID:38950026
Absence of Neutropenia in Patients With Early Exon Nonsense Mutations in ELANE : Clinical Evidence to Support Gene Therapy Approaches for Severe Congenital Neutropenia., PMID:38934594
Identification of key genes as potential diagnostic biomarkers in sepsis by bioinformatics analysis., PMID:38912048
Identification of potential biomarkers for sepsis based on neutrophil extracellular trap-related genes., PMID:38852219
For research use only. Not for human or drug use.
