Catalog No.
RHC28101
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
LPS-associated protein 2, Heat shock protein HSP 90-alpha, HSPCA, HSP90A, HSP 86, Lipopolysaccharide-associated protein 2, HSP86, HSP90AA1, Heat shock 86 kDa, Renal carcinoma antigen NY-REN-38, LAP-2, HSPC1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P07900, P08238
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1L21
Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules., PMID:40497783
An overview of small-molecule agents for the treatment of psoriasis., PMID:39832444
The novel HSP90 monoclonal antibody 9B8 ameliorates articular cartilage degeneration by inhibiting glycolysis via the HIF-1 signaling pathway., PMID:39229534
Extracellular heat shock protein 90 alpha (eHsp90α)'s role in cancer progression and the development of therapeutic strategies., PMID:39126794
Recent studies on non-invasive biomarkers useful in biliary atresia - a literature review., PMID:37717264
Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis., PMID:37563605
17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats., PMID:37517381
Immunoproteomics to identify species-specific antigens in Neospora caninum recognised by infected bovine sera., PMID:36562441
Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies., PMID:36317881
Exposure to nitrate induces alterations in blood parameter responses, liver immunity, and lipid metabolism in juvenile turbot (Scophthalmus maximus)., PMID:36041359
Hepatopancreas toxicity and immunotoxicity of a fungicide, pyraclostrobin, on common carp., PMID:36030005
Impacts of tea polyphenols on growth, antioxidant capacity and immunity in juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂) fed high-lipid diets., PMID:35963561
Necroptotic TNFα-Syndecan 4-TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis., PMID:35278225
HSP90 inhibitor RGRN-305 for oral treatment of plaque-type psoriasis: efficacy, safety and biomarker results in an open-label proof-of-concept study., PMID:34748646
Oral Immunization With a Plant HSP90-SAG1 Fusion Protein Produced in Tobacco Elicits Strong Immune Responses and Reduces Cyst Number and Clinical Signs of Toxoplasmosis in Mice., PMID:34675949
Toxic effects of hexavalent chromium (Cr6+) on bioaccumulation, apoptosis, oxidative damage and inflammatory response in Channa asiatica., PMID:34416396
Heat Shock Protein 90 Involvement in the Development of Idiopathic Epiretinal Membranes., PMID:32716502
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion., PMID:32640214
Biochemical properties of human full-length aryl hydrocarbon receptor (AhR)., PMID:32289173
Chaperone mediated detection of small molecule target binding in cells., PMID:31974362
Tailoring subtractive cell biopanning to identify diffuse gastric adenocarcinoma-associated antigens via human scFv antibodies., PMID:31596953
Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes., PMID:30629603
Glucocorticoid insensitivity by staphylococcal enterotoxin B in keratinocytes of allergic dermatitis is associated with impaired nuclear translocation of the Glucocorticoid Receptor α., PMID:30522881
Autoantibodies to heat shock proteins 60, 70, and 90 in patients with rheumatoid arthritis., PMID:30465159
Effect on Serum Parameters and Immune Responses of Carassius auratus gibelio Exposed to Dietary Lead and Bacillus subtilis., PMID:30324503
HER2 Activation Factors in Arsenite-Exposed Bladder Epithelial Cells., PMID:30137596
PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78., PMID:29178343
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function., PMID:28915917
The Hsp90 inhibitor 17-DMAG decreases infection of porcine circovirus type 2 in mice., PMID:28602838
Heat shock proteins 70 and 90 from Clonorchis sinensis induce Th1 response and stimulate antibody production., PMID:28249599
Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex., PMID:27771897
Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression., PMID:27721406
Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo., PMID:27640183
Two routes of infection with Photobacterium damselae subsp. piscicida are effective in the modulation of the transcription of immune related genes in Solea senegalensis., PMID:27590420
Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes., PMID:27448590
Immunotoxicological effects of cadmium on Labeo rohita, with emphasis on the expression of HSP genes., PMID:26994673
Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment., PMID:26846992
Characterization of calcium oxalate crystal-induced changes in the secretome of U937 human monocytes., PMID:26762788
Immunoexpression patterns for Hypoxia-inducible Factor-1α and von Hippel-Lindau protein, in relation to Hsp90, of human brain tumors., PMID:26592496
Grating coupled SPR microarray analysis of proteins and cells in blood from mice with breast cancer., PMID:26539568
TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form., PMID:26065428
Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE., PMID:25871979
Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm., PMID:25824822
Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway., PMID:25714412
Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells., PMID:25449433
Berberine induces hERG channel deficiency through trafficking inhibition., PMID:25171176
Human epidermal growth factor receptor 2-positive breast cancer: heat shock protein 90 overexpression, Ki67 proliferative index, and topoisomerase II-α co-amplification as predictors of pathologic complete response to neoadjuvant chemotherapy with trastuzumab and docetaxel., PMID:25034441
GIST treatment options after tyrosine kinase inhibitors., PMID:24952730
Targeting the androgen receptor in prostate cancer., PMID:24890318
Molecular profiling of childhood cancer: Biomarkers and novel therapies., PMID:26675306
For research use only. Not for human or drug use.
