Catalog No.
RHC27302
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
CTSL1, MEP, Procathepsin L, Major excreted protein, Cathepsin L1, CTSL
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P07711, O60911, P43235, P09668
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1L12
Integrated renin angiotensin system dysregulation and immune profiles predict COVID-19 disease severity in a South African cohort., PMID:40229302
Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd)., PMID:40175391
Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans., PMID:39316441
Molecular and serological detection of Leishmania infantum (Trypanosomatida: Trypanosomatidae) in domestic dogs in Manaus city, Amazonas, Brazil., PMID:39182231
Diagnosis of fasciolosis antibodies in Brazilian cattle through ELISA employing both native and recombinant antigens., PMID:38534120
Designing and Developing Serological Test for the Diagnosis of Human Fascioliasis Using a New Recombinant Multi-epitope., PMID:38498251
The protease inhibitor E64d might attenuate the development of experimental anti-glomerular basement membrane disease through regulating the activation of Th1 cells., PMID:38295547
Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS-CoV-2 Pseudovirus Entry into Lung ACE2+ Cells., PMID:38194699
[Up to Date of Cyanobacterial Natural Products]., PMID:38171790
Trichinella spiralis cathepsin L induces macrophage M1 polarization via the NF-κB pathway and enhances the ADCC killing of newborn larvae., PMID:37993938
Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer., PMID:37889671
Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L., PMID:37816708
Involvement of cathepsin L in the degradation and degeneration of postovulatory follicle of the medaka ovary†., PMID:37712895
Development of a novel method for diagnosis of fasciolosis based on cathepsin L7 in ruminants., PMID:37657153
Immunodiagnosis of Fascioliasis in Ruminants by ELISA Method: A Mini-Review., PMID:37655153
Immunol detection of cathepsin L from Fasciola hepatica infection in sheep by monoclonal antibody-based colloidal gold test strip assay., PMID:37635410
Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy., PMID:37537587
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase., PMID:37039676
A Bispecific METxMET Antibody-Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes., PMID:36861363
A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors., PMID:36661514
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells., PMID:36313266
Fasciola hepatica Cathepsin L Zymogens: Immuno-Proteomic Evidence for Highly Immunogenic Zymogen-Specific Conformational Epitopes to Support Diagnostics Development., PMID:35849550
Molecular characterization and determination of the biochemical properties of cathepsin L of Trichinella spiralis., PMID:35739604
Introducing a new anti-Rhipicephalus (Boophilus) microplus tick recombinant vaccine candidate using cathepsin and tropomyosin multi-epitope gene., PMID:35529827
Recombinant cysteine proteinase as anti-tick targeting Hyalomma asiaticum infestation., PMID:35218759
Prevalence of Leishmania infantum in Dogs from Deforested Areas of the Amazon Biome., PMID:34898260
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells., PMID:34883264
Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization., PMID:34645933
Mechanisms of SARS-CoV-2 entry into cells., PMID:34611326
Molecular characterization of a novel cathepsin L from Trichinella spiralis and its participation in invasion, development and reproduction., PMID:34453915
Prevalence of Anti-Toxocara canis Antibodies in Dogs Detected with Recombinant Cathepsin L-1 and TES-26 Antigens in Three States of India., PMID:34453704
Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA)., PMID:34271318
Vaccination with cathepsin L mimotopes of Fasciola hepatica in goats reduces worm burden, morphometric measurements, and reproductive structures., PMID:33845124
SerpinB13 antibodies promote β cell development and resistance to type 1 diabetes., PMID:33827974
Recombinant interferon-gamma promotes immunoglobulin G and cytokine memory responses to cathepsin L-like cysteine proteinase of Hyalomma asiaticum and the efficacy of anti-tick., PMID:33735822
The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies., PMID:33713388
Tracking the Behavior of Monoclonal Antibody Product Quality Attributes Using a Multi-Attribute Method Workflow., PMID:33513021
A hemocyte-specific cathepsin L-like cysteine protease is involved in response to 20-hydroxyecdysone and microbial pathogens stimulation in silkworm, Bombyx mori., PMID:33376000
Procathepsin V Is Secreted in a TSH Regulated Manner from Human Thyroid Epithelial Cells and Is Accessible to an Activity-Based Probe., PMID:33266306
Effectiveness of Fasciola gigantica excretory-secretory and recombinant cathepsin L antigens for rapid diagnosis of human fascioliasis using immunochromatographic devices., PMID:33009945
Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach., PMID:32736582
A humanized antibody inhibitor for cathepsin L., PMID:32683733
The expression of Cathepsin L in oral lichen planus., PMID:32612918
Laser capture microdissection in combination with mass spectrometry: Approach to characterization of tissue-specific proteomes of Eudiplozoon nipponicum (Monogenea, Polyopisthocotylea)., PMID:32555742
Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer., PMID:32388635
A novel cystatin derived from Trichinella spiralis suppresses macrophage-mediated inflammatory responses., PMID:32236093
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV., PMID:32221306
The effect of iron on Trichomonas vaginalis TvCP2: a cysteine proteinase found in vaginal secretions of trichomoniasis patients., PMID:32174285
Serodiagnosis of Fasciola gigantica Infection in Buffaloes with Native Cathepsin-L Proteases and Recombinant Cathepsin L1-D., PMID:32077036
Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro., PMID:31996242
For research use only. Not for human or drug use.
