Catalog No.
RHC12901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Applications
IF, IHC, IP, WB
Recommended Dilution
| Application |
Dilution |
| IF |
1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000 |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Steroid 17-alpha-monooxygenase, 17-alpha-hydroxyprogesterone aldolase, CYP17A1, S17AH, Cytochrome P450c17, CYP17
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P05093
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1J96
Note
For research use only.
Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice., PMID:19696014
Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary., PMID:21430025
Interleukins 1α and 1β as regulators of steroidogenesis in human NCI-H295R adrenocortical cells., PMID:21600230
Emerging treatments for castrate-resistant prostate cancer., PMID:21984773
Insulin-like growth factor 3 regulates expression of genes encoding steroidogenic enzymes and key transcription factors in the Nile tilapia gonad., PMID:22337331
Cytochrome b(5) forms homomeric complexes in living cells., PMID:22878120
Cyp17a1 and Cyp19a1 in the zebrafish testis are differentially affected by oestradiol., PMID:23283575
IGF2 increases de novo steroidogenesis in prostate cancer cells., PMID:23319492
Research on the steroidogenesis of proliferated Leydig cells in vitro., PMID:23322215
The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis., PMID:23391632
Novel gonadal characteristics in an aged bovine freemartin., PMID:24630042
Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype., PMID:24706793
Targeting the androgen receptor in prostate cancer., PMID:24890318
CYP17A1 gene polymorphisms and environmental exposure to organochlorine pesticides contribute to the risk of small for gestational age., PMID:25064838
Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17., PMID:26597777
Autoantibodies against Cytochrome P450 Side-Chain Cleavage Enzyme in Dogs (Canis lupus familiaris) Affected with Hypoadrenocorticism (Addison's Disease)., PMID:26618927
Immunohistochemistry of the adrenal in primary aldosteronism., PMID:27119751
Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3., PMID:27793677
Establishment of an in vitro culture model of theca cells from hierarchical follicles in ducks., PMID:28432272
Dose- dependent ameliorative effects of quercetin and l-Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats., PMID:29710542
Neurotrophin-3 stimulates stem Leydig cell proliferation during regeneration in rats., PMID:33090725
Impairment of testes development in Yangzhou ganders by augmentation of leptin receptor signaling., PMID:34051590
Dulaglutide, a long-acting GLP-1 receptor agonist, can improve hyperandrogenemia and ovarian function in DHEA-induced PCOS rats., PMID:34375684
Concomitant occurence of multiple autoantibodies against human cytochromes P450., PMID:34464888
Genetic diagnosis and clinical analysis of 17α-hydroxylase/17, 20-lyase deficiency combined with type 2 diabetes mellitus: A case report., PMID:38206738
Role of p57KIP2 in Stem and Progenitor Leydig Cells of Mouse Testes., PMID:38772531
Characterization of Potential Target Genes of Borneol in Increasing Trastuzumab Sensitivity in HER2+ Trastuzumab-Resistant Breast Cancer: Bioinformatics and In Vitro Studies., PMID:38809634
Testicular mosaicism in non-mosaic postpubertal Klinefelter patients with focal spermatogenesis and in non-mosaic prepubertal Klinefelter boys., PMID:39198007
Dihydroberberine alleviates Th17/Treg imbalance in premature ovarian insufficiency mice via inhibiting Rheb/mTOR signaling., PMID:39472803
Effect of Treatment on Steroidome in Women with Multiple Sclerosis., PMID:40076462
Bimodal genomic approach predicting Semaphorin 7A (SEMA7A) as prognostic biomarker in adrenocortical carcinoma., PMID:40291702
For research use only. Not for human or drug use.
