Catalog No.
RHC09802
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
Trk-A, High affinity nerve growth factor receptor, NTRK1, Tropomyosin-related kinase A, Neurotrophic tyrosine kinase receptor type 1, MTC, TRKA, Tyrosine kinase receptor, TRK, p140-TrkA, TRK1-transforming tyrosine kinase protein, gp140trk, Tyrosine kinase receptor A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P04629, Q16288, Q16620
Applications
IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1J66
Plantamajoside Promotes NGF/TrkA Pathway to Inhibit Neuronal Apoptosis and Improve Diabetic Peripheral Neuropathy., PMID:40289624
Pain mediator NGF improves chondrocyte extracellular matrix synthesis via PI3K/AKT pathway., PMID:40016770
NGF in Neuropathic Pain: Understanding Its Role and Therapeutic Opportunities., PMID:39996814
Utility of a commercial antibody against NTRK1 for western blotting and potential application to immunohistochemistry in adult mouse brain., PMID:39955330
NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas., PMID:39839837
CXCL10 Promotes Spinal Macrophage Recruitment via the JAK/STAT3 Pathway to Induce Pain in Experimental Autoimmune Prostatitis., PMID:39718951
Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models., PMID:39589827
Role of endogenous nerve growth factor in laryngeal airway hyperreactivity and laryngeal inflammation induced by intermittent hypoxia in rats., PMID:39566876
Activation of α7 nicotinic acetylcholine receptor augments nerve growth factor action on PCtrk cells., PMID:39505136
Early-life cisplatin exposure induces neuroinflammation and chemotherapy-induced neuropathic pain., PMID:39428813
Positive Allosteric Modulators of Trk Receptors for the Treatment of Alzheimer's Disease., PMID:39204102
Effect of the novel anti-NGF monoclonal antibody DS002 on the metabolomics of pain mediators, cartilage and bone., PMID:39188953
Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice., PMID:39142441
Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway., PMID:38637413
Respiratory Syncytial Virus Infections in Neonates: A Persisting Problem., PMID:38348152
Neuropilin-1 is a co-receptor for Nerve Growth Factor-evoked pain., PMID:38106002
Canadian Multicentric Pan-TRK (CANTRK) Immunohistochemistry Harmonization Study., PMID:37972928
Influential Serum Kinases (Non-sFlt-1) and Phosphatases in Preeclampsia-Systemic Review and Metanalysis., PMID:37629025
Benzenesulfonamide Analogs: Synthesis, Anti-GBM Activity and Pharmacoprofiling., PMID:37569654
β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells., PMID:37373014
Isolation of human pluripotent stem cell-derived sensory neuron subtypes by immunopanning., PMID:37206924
Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype., PMID:37143894
Multicenter Harmonization Study of Pan-Trk Immunohistochemistry for the Detection of NTRK3 Fusions., PMID:37084942
The Pan-TRK Antibody is a Sensitive and Specific Tool for the Detection of NTRK Fusion Genes., PMID:37017998
Nerve growth factor promotes differentiation and protects the oligodendrocyte precursor cells from in vitro hypoxia/ischemia., PMID:36875668
A systematic comparison of pan-Trk immunohistochemistry assays among multiple cancer types., PMID:36759438
Ntrk1 promotes mesangial cell proliferation and inflammation in rat glomerulonephritis model by activating the STAT3 and p38/ERK MAPK signaling pathways., PMID:36575400
NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol., PMID:36240445
New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease., PMID:36091713
ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion., PMID:35916735
Limited Accuracy of Pan-Trk Immunohistochemistry Screening for NTRK Rearrangements in Follicular-Derived Thyroid Carcinoma., PMID:35806472
Quality Control for IG /TR Marker Identification and MRD Analysis., PMID:35622322
Nerve growth factor receptors in equine synovial membranes vary with osteoarthritic disease severity., PMID:35578994
NGF monoclonal antibody DS002 alleviates chemotherapy-induced peripheral neuropathy in rats., PMID:35468993
Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model., PMID:35417079
Tanezumab for the treatment of osteoarthritis pain., PMID:35412532
Using pan-TRK and RET Immunohistochemistry for the Detection of Fusion Types of Salivary Gland Secretory Carcinoma., PMID:35384876
NTRK Fusions Detection in Paediatric Sarcomas to Expand the Morphological Spectrum and Clinical Relevance of Selected Entities., PMID:35295613
Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers., PMID:35237889
The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908
Localization of Neurotrophin Specific Trk Receptors in Mechanosensory Systems of Killifish (Nothobranchius guentheri)., PMID:34638748
Preparation and characterization of a high-affinity monoclonal antibody against nerve growth factor., PMID:34627999
Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs., PMID:34391918
The WHO 2018 Classification of Cutaneous Melanocytic Neoplasms: Suggestions From Routine Practice., PMID:34277420
The Role of Anti-Nerve Growth Factor Monoclonal Antibodies in the Control of Chronic Cancer and Non-Cancer Pain., PMID:34234542
An update on targets for treating osteoarthritis pain: NGF and TRPV1., PMID:34178580
A Quantitative Bioassay to Determine the Inhibitory Potency of NGF-TrkA Antagonists., PMID:33874771
Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease., PMID:33776745
Retrobulbar administration of purified anti-nerve growth factor in developing rats induces structural and biochemical changes in the retina and cornea., PMID:33614448
Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75NTR but not mature NGF-TrkA., PMID:33482180
For research use only. Not for human or drug use.
