Catalog No.
YHC27401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln139
Predicted molecular weight
17.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07737
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Profilin-1, Profilin I, Epididymis tissue protein Li 184a, PFN1
A missense mutation in close proximity of ALS-linked PFN1 mutations causes only early-onset Paget's disease of bone., PMID:40458045
Oedematic-atrophic astrocytes in hepatic encephalopathy., PMID:40450333
Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1C71G ALS mouse model., PMID:40413526
Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS., PMID:40409555
Nuclear Profilin-1 for DNA Damage Repair Is Involved in Phagocytic Impairment of Senescent Microglia., PMID:40317528
An integrated proteomic classifier to distinguish benign from malignant pulmonary nodules., PMID:40189512
Stepwise single-cell data identifies RNA binding proteins associated with the development of head and neck cancer and tumor microenvironment remodeling., PMID:40171814
Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway., PMID:40149625
Aggregates associated with amyotrophic lateral sclerosis sequester the actin-binding protein profilin 2., PMID:40063831
Clinical Response Characteristics of Salivary Proteins in the Management Strategy of Diabetes-Associated Periodontitis., PMID:40008981
Exploring Molecular Alterations in Breast Cancer Among Indian Women Using Label-Free Quantitative Serum Proteomics., PMID:39990193
Quantitative Proteomics Identifies Profilin-1 as a Pseudouridine-Binding Protein., PMID:39812085
Identification and validation of a novel defined stress granule-related gene signature for predicting the prognosis of ovarian cancer via bioinformatics analysis., PMID:39809219
Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML., PMID:39789150
Shared Gene Expression Dysregulation Across Subtypes of Sanfilippo and Morquio Diseases: The Role of PFN1 in Regulating Glycosaminoglycan Levels., PMID:39735993
Profilin-1 levels in preeclampsia: Associations with disease and adverse neonatal outcomes., PMID:39721377
Overexpression of miR-328-3p Inhibits Epithelial-Mesenchymal Transition in Prostate Cancer by Downregulating PFN1., PMID:39715971
Integrated single-cell and bulk RNA sequencing reveals immune-related SPP1+ macrophages as a potential strategy for predicting the prognosis and treatment of liver fibrosis and hepatocellular carcinoma., PMID:39635536
m6A Modification of Profilin-1 in Vascular Smooth Muscle Cells Drives Phenotype Switching and Neointimal Hyperplasia via Activation of the p-ANXA2/STAT3 Pathway., PMID:39508106
Identification and RT-qPCR Validation of Biomarkers Based on Butyrate Metabolism-Related Genes to Predict Recurrent Miscarriage., PMID:39372587
Peripherally-restricted recurrent infection by engineered E. coli strain modulates hippocampal proteome promoting memory impairments in a rat model., PMID:39341518
A pilot study: Examining cytoskeleton gene expression profiles in Pakistani children with autism spectrum disorder., PMID:39285780
Concomitant presence of a novel ARPP21 variant and CNVs in Chinese familial amyotrophic lateral sclerosis-frontotemporal dementia patients., PMID:39271636
The Potential of Eight Plasma Proteins as Biomarkers in Redefining Leptospirosis Diagnosis., PMID:39150348
PFN1 Knockdown Aggravates Mitophagy to Retard Lung Adenocarcinoma Initiation and M2 Macrophage Polarization., PMID:39120820
Using ALS to understand profilin 1's diverse roles in cellular physiology., PMID:39056295
The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function., PMID:39026010
Identification of a novel lactylation-related gene signature predicts the prognosis of multiple myeloma and experiment verification., PMID:38956267
Neurofilament light chain and profilin-1 dynamics in 30 spinal muscular atrophy type 3 patients treated with nusinersen., PMID:38924263
Serum proteomics study on cognitive impairment after cardiac valve replacement surgery: a prospective observational study., PMID:38912047
Bioprobe-RNA-seq-microRaman system for deep tracking of the live single-cell metabolic pathway chemometrics., PMID:38896978
Protein Profiles and Novel Molecular Biomarkers of Schizophrenia Based on 4D-DIA Proteomics., PMID:38856018
Plasma proteomics analysis reveals potential biomarkers for intracranial aneurysm formation and rupture., PMID:38849112
Proteins Involved in Focal Cell Adhesion and Podosome Formation Are Differentially Expressed during Colorectal Tumorigenesis in AOM-Treated Rats., PMID:38730628
Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules., PMID:38722279
Bioinformation Analysis of Differential Expression Proteins in Different Processes of COVID-19., PMID:38717820
Unveiling Actin Cytoskeleton Role in Mediating Chikungunya-Associated Arthritis: An Integrative Proteome-Metabolome Study., PMID:38717066
Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis., PMID:38700285
Serum anti-CFL1, anti-EZR, and anti-CYPA autoantibody as diagnostic markers in ovarian cancer., PMID:38684875
Correlation between Ki-67 or Profilin-1 Expression Levels, Clinicopathological Characteristics and Postoperative Prognosis in Patients with Bladder Cancer., PMID:38684494
Haplo-insufficiency of Profilin1 in vascular endothelial cells is beneficial but not sufficient to confer protection against experimentally induced atherosclerosis., PMID:38623956
Biomarker discovery with quantum neural networks: a case-study in CTLA4-activation pathways., PMID:38609844
Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis., PMID:38527459
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia., PMID:38509062
Combining bulk and scRNA-seq to explore the molecular mechanisms governing the distinct efferocytosis activities of a macrophage subpopulation in PDAC., PMID:38501838
Orosomucoid 2 as a biomarker of carotid artery atherosclerosis plaque vulnerability through its generation of reactive oxygen species and lipid accumulation in vascular smooth muscle cells., PMID:38447392
Global acetylome profiling indicates EPA impedes but OA promotes prostate cancer motility through altered acetylation of PFN1 and FLNA., PMID:38430206
Phytol and α-Bisabolol Synergy Induces Autophagy and Apoptosis in A549 Cells and Additional Molecular Insights through Comprehensive Proteome Analysis via Nano LC-MS/MS., PMID:38415491
Complex changes in serum protein levels in COVID-19 convalescents., PMID:38396092
Actin-binding protein profilin1 is an important determinant of cellular phosphoinositide control., PMID:38141770
For research use only. Not for human or drug use.
