Catalog No.
YHC27201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys315-Tyr456
Predicted molecular weight
18.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07686
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
N-Acetyl-β-glucosaminidase (NAG),chitobiase,NAG,Beta-hexosaminidase subunit beta, Beta-N-acetylhexosaminidase subunit beta, N-acetyl-beta-glucosaminidase subunit beta, Cervical cancer proto-oncogene 7 protein, Hexosaminidase subunit B, HCC-7, HEXB
Yeast-Produced Human Recombinant Lysosomal β-Hexosaminidase Efficiently Rescues GM2 Ganglioside Accumulation in Tay-Sachs Disease., PMID:40423067
Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'., PMID:40329321
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders., PMID:40305572
Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis., PMID:40016926
HEXB Drives Raised Paucimannosylation in Colorectal Cancer and Stratifies Patient Risk., PMID:39947398
Dysregulation of the NLRP3 Inflammasome and Promotion of Disease by IL-1β in a Murine Model of Sandhoff Disease., PMID:39791736
JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain., PMID:39716224
Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice., PMID:39677060
AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity., PMID:39675352
Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease., PMID:39647513
Hexosaminidase B-driven cancer cell-macrophage co-dependency promotes glycolysis addiction and tumorigenesis in glioblastoma., PMID:39353936
Identification of key regulatory genes involved in myelination after spinal cord injury by GSEA analysis., PMID:39326824
Treating late-onset Tay Sachs disease: Brain delivery with a dual trojan horse protein., PMID:39211733
Lamc1 promotes osteogenic differentiation and inhibits adipogenic differentiation of bone marrow-derived mesenchymal stem cells., PMID:39179716
Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma., PMID:38944674
Tandem mass spectrometric enzyme assay for simultaneous detection of Tay-Sachs and Sandhoff diseases in dried blood spots for newborn screening., PMID:38908075
Lysosome-related biomarkers in preeclampsia and cancers: Machine learning and bioinformatics analysis., PMID:38428097
A novel autoantibody signatures for enhanced clinical diagnosis of pancreatic ductal adenocarcinoma., PMID:37974212
Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions., PMID:37877564
Efficacy of Adeno-Associated Virus Serotype 9-Mediated Gene Therapy for AB-Variant GM2 Gangliosidosis., PMID:37834060
A case of Sandhoff disease caused by a novel β-hexosaminidase B (HEXB) mutation c.118delG (p.A40fs*24): A case report from China., PMID:37327298
Metabolic Cardiomyopathies and Cardiac Defects in Inherited Disorders of Carbohydrate Metabolism: A Systematic Review., PMID:37239976
Revealing the roles of glycosphingolipid metabolism pathway in the development of keloid: a conjoint analysis of single-cell and machine learning., PMID:37168863
Combination of single-nucleus and bulk RNA-seq reveals the molecular mechanism of thalamus haemorrhage-induced central poststroke pain., PMID:37153564
Elucidation of the Late Steps during Hexacosalactone A Biosynthesis in Streptomyces samsunensis OUCT16-12., PMID:36847553
Plasma GM2 ganglioside potential biomarker for diagnosis, prognosis and disease monitoring of GM2-Gangliosidosis., PMID:36709536
Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study., PMID:36635400
P. Ala278Val mutation might cause a pathogenic defect in HEXB folding leading to the Sandhoff disease., PMID:36190588
CRISPR/nCas9-Based Genome Editing on GM2 Gangliosidoses Fibroblasts via Non-Viral Vectors., PMID:36142595
Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease., PMID:35849011
Cobalt (II) Chloride Regulates the Invasion and Survival of Brucella abortus 544 in RAW 264.7 Cells and B6 Mice., PMID:35631117
2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes., PMID:35162960
Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease., PMID:35146484
N-acetyl-β-D-hexosaminidases mediate the generation of paucimannosidic proteins via a putative noncanonical truncation pathway in human neutrophils., PMID:34939086
Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses., PMID:37082581
Hexosaminidase A (HEXA) regulates hepatic sphingolipid and lipoprotein metabolism in mice., PMID:34800307
Analysis of the HEXA, HEXB, ARSA, and SMPD1 Genes in 68 Iranian Patients., PMID:34554397
The GM2 gangliosidoses: Unlocking the mysteries of pathogenesis and treatment., PMID:34450229
Microglia-Specific Expression of HEXA and HEXB Leads to Poor Prognosis in Glioblastoma Patients., PMID:34422641
Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses., PMID:34100447
Identification of Biomarkers Related to Atrial Fibrillation With Mitral Regurgitation., PMID:33541709
Identification and characterization of a residual host cell protein hexosaminidase B associated with N-glycan degradation during the stability study of a therapeutic recombinant monoclonal antibody product., PMID:33476097
Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin., PMID:33448622
Infantile onset Sandhoff disease: clinical manifestation and a novel common mutation in Thai patients., PMID:33407268
New insight into the molecular basis of chromium exposure of Litopenaeus vannamei by transcriptome analysis., PMID:33181946
Generation of pure monocultures of human microglia-like cells from induced pluripotent stem cells., PMID:33096385
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations., PMID:33028409
Pronounced Therapeutic Benefit of a Single Bidirectional AAV Vector Administered Systemically in Sandhoff Mice., PMID:32592687
Novel Hexb-based tools for studying microglia in the CNS., PMID:32541832
Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport., PMID:32397873
For research use only. Not for human or drug use.
