Catalog No.
YHC26801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg23-Ala250
Predicted molecular weight
28.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07510
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHRNG, ACHRG, Acetylcholine receptor subunit gamma
Trophic Factors in Muscle-Nerve Cross-Talk Signaling Augment Muscle Fiber and Motor Endplate Development., PMID:39987522
Repurposing of dipeptidyl peptidase FDA-approved drugs in Alzheimer's disease using network pharmacology and in-silico approaches., PMID:39938415
Exploring the mechanism of cytisine in treating respiratory depression following venomous snake bites based on network pharmacology and molecular docking., PMID:38715819
Effects of DDT and DDE on placental cholinergic receptors., PMID:38615785
A novel missense compound heterozygous variant in TLR1 gene is associated with susceptibility to rheumatoid arthritis - structural perspective and functional annotations., PMID:37479888
[Analysis of a case of Multiple pterygium syndrome due to a novel variant of CHRNG gene]., PMID:37212003
Longitudinal transcriptomic analysis of mouse sciatic nerve reveals pathways associated with age-related muscle pathology., PMID:36905126
Clinical and Pathologic Features of Congenital Myasthenic Syndromes Caused by 35 Genes-A Comprehensive Review., PMID:36835142
Genome-Wide Analysis of Circular RNAs Reveals circCHRNG Regulates Sheep Myoblast Proliferation via miR-133/SRF and MEF2A Axis., PMID:36555706
Combining Gene Mutation with Expression of Candidate Genes to Improve Diagnosis of Escobar Syndrome., PMID:36292632
Overexpression of cholinergic receptor nicotinic gamma subunit inhibits proliferation and differentiation of bovine preadipocytes., PMID:36108684
Mutual stimulatory signaling between human myogenic cells and rat cerebellar neurons., PMID:34713978
The Clinical and Genotypic Spectrum of Scoliosis in Multiple Pterygium Syndrome: A Case Series on 12 Children., PMID:34440395
[Clinical Characteristics and Genetic Analysis of Klippel-Feil Syndrome]., PMID:33663658
Recessive MYH3 variants cause "Contractures, pterygia, and variable skeletal fusions syndrome 1B" mimicking Escobar variant multiple pterygium syndrome., PMID:32902138
Profile of the Nicotinic Cholinergic Receptor Alpha 7 Subunit Gene Expression is Associated with Response to Varenicline Treatment., PMID:32640505
Utilization of Whole Exome Sequencing in Lethal Form of Multiple Pterygium Syndrome: Identification of Mutations in Embryonal Subunit of Acetylcholine Receptor., PMID:32587836
Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology., PMID:32547535
Use of gene expression profile to identify potentially relevant transcripts to myofibrillar fragmentation index trait., PMID:32285226
Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis., PMID:31456060
Molecular indicators of denervation in aging human skeletal muscle., PMID:31314910
Prenatal diagnosis of fetal skeletal dysplasia using targeted next-generation sequencing: an analysis of 30 cases., PMID:31299979
Lethal multiple pterygium syndrome., PMID:31068350
Myasthenia gravis., PMID:31048687
CHRNG-related nonlethal multiple pterygium syndrome: Muscle imaging pattern and clinical, histopathological, and molecular genetic findings., PMID:30868735
Molecular Diagnosis of Rare Autosomal Recessive Escobar Syndrome in a Consanguineous Pakistani Family., PMID:30461311
Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients., PMID:29765992
Correlation of HLA-DQ and TNF-α gene polymorphisms with ocular myasthenia gravis combined with thyroid-associated ophthalmopathy., PMID:28119492
Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice., PMID:27964759
When do myopia genes have their effect? Comparison of genetic risks between children and adults., PMID:27611182
Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats., PMID:27496100
Truncating CHRNG mutations associated with interfamilial variability of the severity of the Escobar variant of multiple pterygium syndrome., PMID:27245440
Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence., PMID:27085880
Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy., PMID:26929355
Salbutamol-responsive fetal acetylcholine receptor inactivation syndrome., PMID:26791147
Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin., PMID:26752647
Switch to double positive late onset MuSK myasthenia gravis following thymomectomy in paraneoplastic AChR antibody positive myasthenia gravis., PMID:26645394
Rare cases of congenital arthrogryposis multiplex caused by novel recurrent CHRNG mutations., PMID:25608830
Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence., PMID:25537362
Germline mutations in RYR1 are associated with foetal akinesia deformation sequence/lethal multiple pterygium syndrome., PMID:25476234
Spectrum of neuropathophysiology in spinal muscular atrophy type I., PMID:25470343
Orthopaedic manifestations and treatment outcome of two siblings with Escobar syndrome and homozygous mutations in the CHRNG gene., PMID:25411939
Anti-agrin autoantibodies in myasthenia gravis., PMID:24793185
Nonlethal multiple pterygium syndrome: Escobar syndrome., PMID:24472885
Is webbing (pterygia) a constant feature in patients with Escobar syndrome?, PMID:24254455
Neuromotor synapses in Escobar syndrome., PMID:24038971
Clinical phenotype and the lack of mutations in the CHRNG, CHRND, and CHRNA1 genes in two Indian families with Escobar syndrome., PMID:23448903
Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFβ3-knockout mice alleles: RNA-Seq analysis of TGFβ3 Mice., PMID:23421592
Alternatively spliced variants of gamma-subunit of muscle-type acetylcholine receptor in fetal and adult skeletal muscle of mouse., PMID:22488527
Ocular and generalized myasthenia gravis induced by human acetylcholine receptor γ subunit immunization., PMID:22246876
For research use only. Not for human or drug use.
