Catalog No.
RHB63001
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O95390
Applications
IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1G46
Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control., PMID:40481031
ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice., PMID:39994804
GDF11 alleviates cardiac ischemia/reperfusion injury by suppressing the mtDNA damage-inflammatory response axis., PMID:39961488
The regulatory effect of growth differentiation factor 11 on different cells., PMID:38143761
Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans., PMID:37742057
Acute endurance exercise modulates growth differentiation factor 11 in cerebrospinal fluid of healthy young adults., PMID:37033257
The hepatic effects of GDF11 on health and disease., PMID:36584866
GDF11 promotes wound healing in diabetic mice via stimulating HIF-1ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization., PMID:36347996
GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway., PMID:36293138
Detection of GDF11 by using a Ti3C2-MXene-based fiber SPR biosensor., PMID:34809067
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs., PMID:34520530
GDF11 enhances therapeutic functions of mesenchymal stem cells for angiogenesis., PMID:34384486
Novel myostatin-specific antibody enhances muscle strength in muscle disease models., PMID:33495503
TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass., PMID:33250771
Myostatin Inhibitors: Panacea or Predicament for Musculoskeletal Disorders?, PMID:32911580
GDF11 replenishment protects against hypoxia-mediated apoptosis in cardiomyocytes by regulating autophagy., PMID:32861661
Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss., PMID:31983062
Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells., PMID:31767630
GDF11 impairs liver regeneration in mice after partial hepatectomy., PMID:31654062
Steady-state and regenerative hematopoiesis occurs normally in mice in the absence of GDF11., PMID:31530563
GDF11 is not the target of luspatercept., PMID:31395583
Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals., PMID:30998775
Luspatercept for the treatment of anemia in myelodysplastic syndromes and primary myelofibrosis., PMID:30602619
Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle., PMID:30563942
GDF11 antagonizes TNF-α-induced inflammation and protects against the development of inflammatory arthritis in mice., PMID:30407878
Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults., PMID:30380014
Growth differentiation factor 11 ameliorates experimental colitis by inhibiting NLRP3 inflammasome activation., PMID:30188752
GDF11 Improves Angiogenic Function of EPCs in Diabetic Limb Ischemia., PMID:30026260
[Not Available]., PMID:29463398
Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15., PMID:29425507
Blocking extracellular activation of myostatin as a strategy for treating muscle wasting., PMID:29396542
A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys., PMID:29121992
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy., PMID:29109273
A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform., PMID:28599707
GDF11 Attenuates Development of Type 2 Diabetes via Improvement of Islet β-Cell Function and Survival., PMID:28450417
Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms., PMID:26917343
Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925
Production of bioactive chicken (Gallus gallus) follistatin-type proteins in E. coli., PMID:26302688
Systemic factors mediate reversible age-associated brain dysfunction., PMID:25400086
Development of novel activin-targeted therapeutics., PMID:25399825
Identification and expression of a novel transcript of the growth and differentiation factor-11 gene., PMID:24378996
An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy., PMID:24298022
PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations., PMID:21480163
Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease., PMID:20618701
Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators., PMID:18927237
Autoregulation of neurogenesis by GDF11., PMID:12546816
Mesendoderm induction and reversal of left-right pattern by mouse Gdf1, a Vg1-related gene., PMID:11071769