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Anti-GDF11/BMP11 Antibody (R1G46)

Catalog #:   RHB63001 Specific References (47) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IF, IHC, WB
Accession: O95390
Overview

Catalog No.

RHB63001

Species reactivity

Human, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000

Target

GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O95390

Applications

IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1G46

Data Image
  • Western blot
    All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
  • Western blot
    Western blot analysis of BMP11 expression in (1) HeLa cell lysate; (2) C6 cell lysate.
References

Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control., PMID:40481031

ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice., PMID:39994804

GDF11 alleviates cardiac ischemia/reperfusion injury by suppressing the mtDNA damage-inflammatory response axis., PMID:39961488

The regulatory effect of growth differentiation factor 11 on different cells., PMID:38143761

Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans., PMID:37742057

Acute endurance exercise modulates growth differentiation factor 11 in cerebrospinal fluid of healthy young adults., PMID:37033257

The hepatic effects of GDF11 on health and disease., PMID:36584866

GDF11 promotes wound healing in diabetic mice via stimulating HIF-1ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization., PMID:36347996

GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway., PMID:36293138

Detection of GDF11 by using a Ti3C2-MXene-based fiber SPR biosensor., PMID:34809067

Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs., PMID:34520530

GDF11 enhances therapeutic functions of mesenchymal stem cells for angiogenesis., PMID:34384486

Novel myostatin-specific antibody enhances muscle strength in muscle disease models., PMID:33495503

TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass., PMID:33250771

Myostatin Inhibitors: Panacea or Predicament for Musculoskeletal Disorders?, PMID:32911580

GDF11 replenishment protects against hypoxia-mediated apoptosis in cardiomyocytes by regulating autophagy., PMID:32861661

Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss., PMID:31983062

Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells., PMID:31767630

GDF11 impairs liver regeneration in mice after partial hepatectomy., PMID:31654062

Steady-state and regenerative hematopoiesis occurs normally in mice in the absence of GDF11., PMID:31530563

GDF11 is not the target of luspatercept., PMID:31395583

Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals., PMID:30998775

Luspatercept for the treatment of anemia in myelodysplastic syndromes and primary myelofibrosis., PMID:30602619

Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle., PMID:30563942

GDF11 antagonizes TNF-α-induced inflammation and protects against the development of inflammatory arthritis in mice., PMID:30407878

Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults., PMID:30380014

Growth differentiation factor 11 ameliorates experimental colitis by inhibiting NLRP3 inflammasome activation., PMID:30188752

GDF11 Improves Angiogenic Function of EPCs in Diabetic Limb Ischemia., PMID:30026260

[Not Available]., PMID:29463398

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15., PMID:29425507

Blocking extracellular activation of myostatin as a strategy for treating muscle wasting., PMID:29396542

A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys., PMID:29121992

Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy., PMID:29109273

A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform., PMID:28599707

GDF11 Attenuates Development of Type 2 Diabetes via Improvement of Islet β-Cell Function and Survival., PMID:28450417

Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms., PMID:26917343

Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925

Production of bioactive chicken (Gallus gallus) follistatin-type proteins in E. coli., PMID:26302688

Systemic factors mediate reversible age-associated brain dysfunction., PMID:25400086

Development of novel activin-targeted therapeutics., PMID:25399825

Identification and expression of a novel transcript of the growth and differentiation factor-11 gene., PMID:24378996

An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy., PMID:24298022

PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations., PMID:21480163

Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease., PMID:20618701

Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators., PMID:18927237

Autoregulation of neurogenesis by GDF11., PMID:12546816

Mesendoderm induction and reversal of left-right pattern by mouse Gdf1, a Vg1-related gene., PMID:11071769

Datasheet
$ 290
Product specifications
50 μg 290 100 μg 484

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For research use only. Not for human or drug use.

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Anti-GDF11/BMP11 Antibody (R1G46) [RHB63001]
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