Catalog No.
YHC24101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe216-Gly465
Predicted molecular weight
55.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07237
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein disulfide-isomerase, Cellular thyroid hormone-binding protein, PDI, p55, ERBA2L, PO4DB, Prolyl 4-hydroxylase subunit beta, P4HB, PDIA1
USP5-induced deubiquitination of P4HB alleviates ER stress-mediated apoptosis in intestinal ischemia/reperfusion., PMID:40506531
FMO3 exacerbates hepatic endoplasmic reticulum stress in drug-induced liver injury by inhibiting CREB3/P4HB axis and activating TMAO-mediated PERK pathway., PMID:40345485
P4HB, a novel succinated protein, is essential for fumarate-induced cancer metastasis., PMID:40318732
Distribution of epithelial endoplasmic reticulum stress-related proteins in adult and pediatric Crohn's disease: Association with inflammation and fibrosis., PMID:40300947
Biliverdin alleviates cerebral ischemia-reperfusion injury by regulating the P4hb/MAPK/mTOR pathway to inhibit autophagy., PMID:40258578
Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies., PMID:40240912
Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1., PMID:40202514
Computational profiling of molecular biomarkers in congenital disorders of glycosylation Type-I and binding analysis of Ginkgolide A with P4HB., PMID:40117797
Endoplasmic reticulum stress causes long bone shortening in P4hbC402R/+ mice: A mouse model exhibiting significant features of cole-carpenter syndrome driven by P4HB mutations., PMID:39778777
Potential role of P4HB in the tumor microenvironment and its clinical prognostic value: a comprehensive pan-cancer analysis and experimental validation with a focus on KIRC., PMID:39754183
P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker., PMID:39580454
Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption., PMID:39494721
Analysis of Punicalin and Punicalagin Interaction with PDIA3 and PDIA1., PMID:39408858
Inhibition of protein disulfide isomerase mitigates steroid-induced osteonecrosis of the femoral head by suppressing osteoclast activity through the reduction of cellular oxidative stress., PMID:39393751
P4HB regulates the TGFβ/SMAD3 signaling pathway through PRMT1 to participate in high glucose-induced epithelial-mesenchymal transition and fibrosis of renal tubular epithelial cells., PMID:39251943
Efficacy Evaluation of Treatment of Psoriasis Via Narrow Band-Ultraviolet Radiation., PMID:39188934
Epididymal mRNA expression profiles for the protein disulfide isomerase gene family: Modulation by development and androgens., PMID:39087751
Redox Enzymes P4HB and PDIA3 Interact with STIM1 to Fine-Tune Its Calcium Sensitivity and Activation., PMID:39062821
Detection of neoplastic-immune hybrid cells with metastatic properties in uveal melanoma., PMID:39030653
Unveiling a new strategy for PDIA1 inhibition: Integration of activity-based probes profiling and targeted degradation., PMID:38917491
Effects of alcohol consumption and tobacco smoking on the composition of the ensemble of drug metabolizing enzymes and transporters in human liver., PMID:38798409
ARIP: A Tool for Precise Interatomic Contact Area and Volume Calculation in Proteins., PMID:38791216
Fabrication of Bioresorbable Barrier Membranes from Gelatin/Poly(4-Hydroxybutyrate) (P4HB)., PMID:38621113
Exome sequencing identified mutations in the WNT1 and COL1A2 genes in osteogenesis imperfecta cases., PMID:38536562
De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis., PMID:38489269
SHH regulates penile morphology and smooth muscle through a mechanism involving BMP4 and GREM1., PMID:38451321
Two-Year Preclinical Evaluation of Long-Term Absorbable Poly-4-hydroxybutyrate Scaffold for Surgical Correction of Pelvic Organ Prolapse., PMID:38430238
Exploring the Influence of Zinc Ions on the Conformational Stability and Activity of Protein Disulfide Isomerase., PMID:38396772
The Regenerative Capacity of Tissue-Engineered Amniotic Membranes., PMID:38391263
Integration of multi-omics and clinical treatment data reveals bladder cancer therapeutic vulnerability gene combinations and prognostic risks., PMID:38299148
Analysis of joint protein expression profile in anterior disc displacement of TMJ with or without OA., PMID:38251222
Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion., PMID:38211723
Detection of neoplastic-immune hybrid cells with metastatic properties in uveal melanoma., PMID:38106024
ARID1A loss induces P4HB to activate fibroblasts to support lung cancer cell growth, invasion, and chemoresistance., PMID:38100120
Targeting Prolyl 4-Hydroxylase Subunit Beta (P4HB) in Cancer: New Roads to Travel., PMID:38029391
Analysis of uveal melanoma scRNA sequencing data identifies neoplastic-immune hybrid cells that exhibit metastatic potential., PMID:37961378
Circular RNA P4HB promotes glycolysis and tumor progression by binding with PKM2 in lung adenocarcinoma., PMID:37880717
Establishment of prognostic model of bladder cancer based on apoptosis-related genes, in which P4HB promotes BLCA progression., PMID:37845668
MiR-204-5p regulates HUVEC cell inflammation and apoptosis by targeting P4HB., PMID:37807312
Deciphering the immunological and prognostic features of bladder cancer through platinum-resistance-related genes analysis and identifying potential therapeutic target P4HB., PMID:37790935
Prolyl 4-hydroxylase subunit beta (P4HB) could serve as a prognostic and radiosensitivity biomarker for prostate cancer patients., PMID:37480146
Expression, localization, and function of P4HB in the spermatogenesis of Chinese mitten crab (Eriocheir sinensis)., PMID:37334119
Establishment of cancer-associated fibroblasts-related subtypes and prognostic index for prostate cancer through single-cell and bulk RNA transcriptome., PMID:37270661
Multifunctional Fluorinated Lubricant-Infused Poly(4-Hydroxybutyrate) (P4HB) Membranes for Full-Thickness Abdominal Wall Defect Repair., PMID:37243394
The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis., PMID:37205565
A meta-analysis and bioinformatics analysis of P4HB expression levels in the prognosis of cancer patients., PMID:37119730
Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors., PMID:37070480
Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines., PMID:37070091
Integrative analysis of transcriptomic landscape and urinary signature reveals prognostic biomarkers for clear cell renal cell carcinoma., PMID:37035174
The Effect of N6-Methyladenosine Regulators and m6A Reader YTHDC1-Mediated N6-Methyladenosine Modification Is Involved in Oxidative Stress in Human Aortic Dissection., PMID:36819785
For research use only. Not for human or drug use.
