Catalog No.
RHB44603
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Applications
IF, IHC, WB
Recommended Dilution
| Application |
Dilution |
| IF |
1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
Target
Autophagy-related protein 12, APG12-like, Ubiquitin-like protein ATG12, APG12L, APG12, ATG12
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O94817
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1G02
Note
For research use only.
NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia., PMID:17213804
Autophagy during proliferation and encystation in the protozoan parasite Entamoeba invadens., PMID:17923513
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production., PMID:18849965
Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease., PMID:20102518
IL-6 inhibits IFN-γ induced autophagy in Mycobacterium tuberculosis H37Rv infected macrophages., PMID:22426116
Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment., PMID:23307622
The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer., PMID:23965851
Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells., PMID:24211352
Electroconvulsive seizures enhance autophagy signaling in rat hippocampus., PMID:24316174
Post-transcriptional regulation of autophagy in C2C12 myotubes following starvation and nutrient restoration., PMID:25043686
Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production., PMID:25151985
Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy., PMID:26923481
A Prospective Pharmacogenomic Study of Crohn's Disease Patients during Routine Therapy with Anti-TNF-α Drug Adalimumab: Contribution of ATG5, NFKB1, and CRP Genes to Pharmacodynamic Variability., PMID:27096233
[Effect of Xinfeng Capsule on AS Patients and Their Serum Immunoglobulin Subtypes and Peripheral Lymphocyte Autophagy]., PMID:27236888
Tranexamic acid inhibits melanogenesis by activating the autophagy system in cultured melanoma cells., PMID:28669590
Crosstalk Influence between P38MAPK and Autophagy on Mitochondria-Mediated Apoptosis Induced by Anti-Fas Antibody/Actinomycin D in Human Hepatoma Bel-7402 Cells., PMID:29039784
Effect of follicle cell autophagy on gonadal development of triploid female rainbow trout (Oncorhynchus mykiss)., PMID:29086110
ATG5 is required for B cell polarization and presentation of particulate antigens., PMID:30196744
Decreased Expression of MicroRNA-107 in B Lymphocytes of Patients with Antibody-Mediated Renal Allograft Rejection., PMID:30333363
Endometrial autophagy is essential for embryo implantation during early pregnancy., PMID:32072231
Alpha-neoendorphin can reduce UVB-induced skin photoaging by activating cellular autophagy., PMID:32526201
Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice., PMID:32677505
An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells., PMID:32897127
Vitamin D - A host directed autophagy mediated therapy for tuberculosis., PMID:33039674
The Role of Autophagy-Mediated Dengue Virus Antibody-Dependent Enhancement Infection of THP-1 Cells., PMID:33202415
Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells., PMID:33673233
Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes., PMID:33730050
The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore., PMID:33783314
Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells., PMID:33801244
Positively Correlated CD47 Activation and Autophagy in Umbilical Cord Blood-Derived Mesenchymal Stem Cells during Senescence., PMID:33936211
Effects of in vitro vitamin D treatment on function of T cells and autophagy mechanisms in high-fat diet-induced obese mice., PMID:34858547
Evaluation of the mTORC activity in the presence of Toxoplasma gondii and azathioprine in human monocyte cell line., PMID:36941573
Upregulation of ATG9b by propranolol promotes autophagic cell death of hepatic stellate cells to improve liver fibrosis., PMID:37970991
Senecavirus A induces mitophagy to promote self-replication through direct interaction of 2C protein with K27-linked ubiquitinated TUFM catalyzed by RNF185., PMID:38084826
MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest., PMID:39586385
For research use only. Not for human or drug use.
