Catalog No.
RHB05001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000
Target
Nibrin, P95, NBS1, Cell cycle regulatory protein p95, NBS, Nijmegen breakage syndrome protein 1, NBN
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O60934
Applications
IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1E92
Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis., PMID:38908771
Comprehensive characterization of genomic features and clinical outcomes following targeted therapy and secondary cytoreductive surgery in OCCC: a single center experience., PMID:38606821
Safety, immunogenicity and efficacy of an mRNA-based COVID-19 vaccine, GLB-COV2-043, in preclinical animal models., PMID:38040905
Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis., PMID:37652913
Antibodies Produced in Response to a Live-Attenuated Dengue Vaccine Are Functional in Activating the Complement System., PMID:36461942
Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A., PMID:32313230
PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy., PMID:31053471
Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model., PMID:27467592
Clinical course and therapeutic implications for lymphoid malignancies in Nijmegen breakage syndrome., PMID:26826318
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes., PMID:26405826
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells., PMID:26073085
Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation., PMID:25485873
Impact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel., PMID:25268703
Pulmonary coccidioidomycosis: pictorial review of chest radiographic and CT findings., PMID:25019431
The MRN-CtIP pathway is required for metaphase chromosome alignment., PMID:23434370
High LET radiation amplifies centrosome overduplication through a pathway of γ-tubulin monoubiquitination., PMID:23433796
The defect in humoral immunity in patients with Nijmegen breakage syndrome is explained by defects in peripheral B lymphocyte maturation., PMID:22851427
[Heterozygous carriers of Slavic mutation 657del5 of NBN gene in patients with colorectal cancer]., PMID:21560448
siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells., PMID:21501031
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1., PMID:21297581
Autophosphorylation and ATM activation: additional sites add to the complexity., PMID:21149446
UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells., PMID:20947453
Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex., PMID:20943970
MCL-1 localizes to sites of DNA damage and regulates DNA damage response., PMID:20647761
Loss of juxtaposition of RAG-induced immunoglobulin DNA ends is implicated in the precursor B-cell differentiation defect in NBS patients., PMID:20378756
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair., PMID:20081839
Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation., PMID:19896956
DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories., PMID:19597347
Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1., PMID:19338747
Unique morphological spectrum of lymphomas in Nijmegen breakage syndrome (NBS) patients with high frequency of consecutive lymphoma formation., PMID:18788073
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites., PMID:18582474
Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats., PMID:18253720
Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling., PMID:18248856
NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse., PMID:18003706
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients., PMID:17786349
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain., PMID:17706468
Defective signal joint recombination in fanconi anemia fibroblasts reveals a role for Rad50 in V(D)J recombination., PMID:17524422
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis., PMID:17485521
The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity., PMID:17121922
Heat-induced phosphorylation of NBS1 in human skin fibroblast cells., PMID:16823774
The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions., PMID:15937485
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response., PMID:15916964
Nibrin functions in Ig class-switch recombination., PMID:15668383
Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain., PMID:15635255
The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia., PMID:15451479
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention., PMID:15201865
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts., PMID:15199173
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks., PMID:15180989
Retrospective diagnosis and subsequent prenatal diagnosis of Nijmegen breakage syndrome., PMID:14974117
Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells., PMID:12509260
For research use only. Not for human or drug use.
