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Anti-KDM1A Antibody (R1E53)

Catalog #:   RHA88901 Specific References (29) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IF, IP, WB
Accession: O60341
Overview

Catalog No.

RHA88901

Species reactivity

Human, Rat, Hamster

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000

Target

Lysine-specific histone demethylase 1A, KDM1, [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A, Flavin-containing amine oxidase domain-containing protein 2, KIAA0601, BRAF35-HDAC complex protein BHC110, KDM1A, AOF2, LSD1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O60341

Applications

IF, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1E53

Data Image
  • Immunofluorescence
    Immunocytochemistry analysis of KDM4B/JMJD2B(green) in Hela using KDM4B/JMJD2B antibody,and DAPI(blue)
  • Western blot
    Western blot analysis of KDM1/LSD1 in Jurkat lysates using KDM1A antibody.
  • Western blot
    Western blot analysis of KDM1/LSD1 in Hela, CHO-K1, C6, Jurkat lysates using KDM1/LSD1 antibody.
References

Lysine-specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti-programmed death 1 therapy in liver cancer., PMID:40356247

LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer., PMID:40088674

Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy., PMID:39872303

Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis., PMID:34771652

Targeting LSD1 suppresses stem cell-like properties and sensitizes head and neck squamous cell carcinoma to PD-1 blockade., PMID:34689153

Phase Ib study of patients with metastatic castrate-resistant prostate cancer treated with different sequencing regimens of atezolizumab and sipuleucel-T., PMID:34376554

LSD1 silencing contributes to enhanced efficacy of anti-CD47/PD-L1 immunotherapy in cervical cancer., PMID:33731702

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch., PMID:32612611

Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade., PMID:30111819

Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9., PMID:29959229

LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation., PMID:29618057

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma., PMID:29559475

RORα2 requires LSD1 to enhance tumor progression in breast cancer., PMID:28931919

Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression., PMID:26671628

Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium., PMID:26446227

Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry., PMID:25759518

Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2)., PMID:25036127

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate., PMID:24687155

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development., PMID:24619213

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion., PMID:23054398

Novel colorimetric assay of LSD1 activity using gold nanoparticles., PMID:22534778

A sensitive, homogeneous, and high-throughput assay for lysine-specific histone demethylases at the H3K4 site., PMID:22192306

Screening assays for epigenetic targets using native histones as substrates., PMID:21965113

Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4., PMID:21940714

Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1)., PMID:21876670

High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases., PMID:21859682

Screening for lysine-specific demethylase-1 inhibitors using a label-free high-throughput mass spectrometry assay., PMID:21855527

Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1., PMID:19193804

Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation., PMID:19124609

Datasheet

Document Download

Anti-KDM1A Antibody (R1E53).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

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Anti-KDM1A Antibody (R1E53) [RHA88901]
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