Catalog No.
RHA72001
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
Spry-2, SPRY2, Protein sprouty homolog 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O43597
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1E18
MicroRNA-21-5p participates in IgA nephropathy by driving T helper cell polarization., PMID:31863364
Spred negatively regulates lens growth by modulating epithelial cell proliferation and fiber differentiation., PMID:30290165
Effect of FGF2 on the activity of SPRYs/DUSP6/ERK signaling pathway in endometrial glandular epithelial cells of endometriosis., PMID:29630097
Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred., PMID:29501879
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura., PMID:29497996
Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways., PMID:27415760
Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling., PMID:27277891
Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL., PMID:26809508
Pathways driving the endocytosis of mutant and wild-type EGFR in cancer., PMID:25594057
SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer., PMID:23624922
Sprouty genes function in suppression of prostate tumorigenesis., PMID:23150596
Immunolocalization of sprouty-1 and sprouty-2 in developing rat lung., PMID:22236546
3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM., PMID:21998699
Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy., PMID:21909357
Activation of unfolded protein response in transgenic mouse lenses., PMID:21310900
The elusive role of the SPRY2 domain in RyR1., PMID:21239886
Sprouty2 downregulates angiogenesis during mouse skin wound healing., PMID:21076020
Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells., PMID:20624167
A novel role of Sprouty 2 in regulating cellular apoptosis., PMID:18070883
Regulator of epidermal growth factor signaling: Sprouty., PMID:16780213
Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia., PMID:15937482
[Angiogenic growth factors in rheumatoid arthritis]., PMID:15799344
Chick delta1-crystallin enhancer influences mouse alphaA-crystallin promoter activity in transgenic mice., PMID:15505059
For research use only. Not for human or drug use.
