Catalog No.
RHA69702
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
BCL2L11, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death, BIM, Bcl2-L-11
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O43521
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1E10
Novel PI3kδ inhibitor roginolisib synergizes with venetoclax in hematologic malignancies., PMID:40534489
Development of a Novel Biomarker Platform for Profiling Key Protein-Protein Interactions to Predict the Efficacy of BH3-Mimetic Drugs., PMID:40507334
Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement., PMID:38562920
Development of an Oral IgA Response against SARS-CoV-2 Following Immunization with Different COVID-19 Vaccines., PMID:38140560
Mesenchymal Stem Cell Microvesicles from Adipose Tissue: Unraveling Their Impact on Primary Ovarian Cancer Cells and Their Therapeutic Opportunities., PMID:37958844
Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells., PMID:37664151
Efficacy of retreatment with polatuzumab vedotin in combination with rituximab in polatuzumab vedotin-resistant DLBCL models., PMID:37548343
A Step Forward toward Selective Activation/Inhibition of Bak, a Pro-Apoptotic Member of the Bcl-2 Protein Family: Discovery of New Prospective Allosteric Sites Using Molecular Dynamics., PMID:37226335
Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer., PMID:36622698
SymMap database and TMNP algorithm reveal Huanggui Tongqiao granules for Allergic rhinitis through IFN-mediated neuroimmuno-modulation., PMID:36252774
Molecular classification of human papillomavirus-positive cervical cancers based on immune signature enrichment., PMID:36203656
Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy., PMID:36048524
A Novel Anti-CD22 scFv.Bim Fusion Protein Effectively Induces Apoptosis in Malignant B cells and Promotes Cytotoxicity., PMID:35838885
Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory., PMID:35716600
Naturally-Occurring Antibodies Against Bim are Decreased in Alzheimer's Disease and Attenuate AD-type Pathology in a Mouse Model., PMID:35570231
Resistance to obinutuzumab-induced antibody-dependent cellular cytotoxicity caused by abnormal Fas signaling is overcome by combination therapies., PMID:35218445
Anti-cancer effects of pyrazole-platinum(II) complexes combined with anti-MUC1 monoclonal antibody versus monotherapy in DLD-1 and HT-29 colon cancer cells., PMID:35121220
Nuclear Envelope Alterations in Myotonic Dystrophy Type 1 Patient-Derived Fibroblasts., PMID:35008948
EGFR Inhibitors Plus Bevacizumab are Superior Than EGFR Inhibitors Alone as First-Line Setting in Advanced NSCLC With EGFR Mutations and BIM Deletion Polymorphisms (BIM-CLICaP)., PMID:34994616
EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8+ T Cells., PMID:34925340
CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1., PMID:34707185
Comprehensive characterization of central BCL-2 family members in aberrant eosinophils and their impact on therapeutic strategies., PMID:34654952
The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody Responses and NF-κB Pathway Activation., PMID:34543116
Impaired B Cell Apoptosis Results in Autoimmunity That Is Alleviated by Ablation of Btk., PMID:34512628
Pathology Features of Immune and Inflammatory Myopathies, Including a Polymyositis Pattern, Relate Strongly to Serum Autoantibodies., PMID:34363679
The interactions of bacteriophage Ace and Shiga toxin-producing Escherichia coli during biocontrol., PMID:34329454
Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection., PMID:34247195
Neurotrophin-3 contributes to benefits of human embryonic stem cell-derived cardiovascular progenitor cells against reperfused myocardial infarction., PMID:33529481
CRISPR-based strategies in infectious disease diagnosis and therapy., PMID:33393066
Budget Impact Analysis of the Introduction of Rituximab and Trastuzumab Intravenous Biosimilars to EU-5 Markets., PMID:33368051
Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells., PMID:33311449
Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation., PMID:33086063
Bim establishes the B-cell repertoire from early to late in the immune response., PMID:32889526
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development., PMID:32868930
Targeting HER3, a Catalytically Defective Receptor Tyrosine Kinase, Prevents Resistance of Lung Cancer to a Third-Generation EGFR Kinase Inhibitor., PMID:32847130
FOXO3a accumulation and activation accelerate oxidative stress-induced podocyte injury., PMID:32786113
BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression., PMID:32717030
Therapeutic potential of muscle growth promoters in a stress urinary incontinence model., PMID:32686522
ABC Efflux Transporters and the Circuitry of miRNAs: Kinetics of Expression in Cancer Drug Resistance., PMID:32340269
Activation of Protein Kinase Cδ Contributes to the Induction of Src/EGF Receptor/ERK Signaling in Ammonia-treated Astrocytes., PMID:32125625
Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production., PMID:32073750
Vasoinhibin generation and effect on neuronal apoptosis in the hippocampus of late mouse embryos., PMID:32048872
E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells., PMID:32005754
Involvement of Up-regulation of Death Receptors and Bim in Hispolon-mediated TNF-related Apoptosis-inducing Ligand Sensitization in Human Renal Carcinoma., PMID:31624721
High-throughput autoantibody analysis in malignant pleural effusion and tuberculosis pleural effusion., PMID:31567996
Blood Predictive Biomarkers for Patients With Non-small-cell Lung Cancer Associated With Clinical Response to Nivolumab., PMID:31562055
ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells., PMID:31443721
Proapoptotic protein BIM as a novel prognostic marker in mantle cell lymphoma., PMID:31425695
Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1., PMID:31181072
Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth., PMID:31178149
For research use only. Not for human or drug use.
