Catalog No.
RHA68003
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
High temperature requirement protein A2, OMI, HtrA2, PRSS25, Serine protease 25, Serine proteinase OMI, Serine protease HTRA2, mitochondrial, HTRA2, Omi stress-regulated endoprotease
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O43464
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1E07
Parkinson's disease neurons exhibit alterations in mitochondrial quality control proteins., PMID:37553379
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration., PMID:36064790
Copper-imidazo[1,2-a]pyridines differentially modulate pro- and anti-apoptotic protein and gene expression in HL-60 and K562 leukaemic cells to cause apoptotic cell death., PMID:34634376
Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Networks in Retinal Tissues., PMID:34440217
Analysis of Proapoptotic Protein Trafficking to and from Mitochondria., PMID:34096003
EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway., PMID:32978170
Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells., PMID:31683713
Synthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy., PMID:31443184
Immune response against HtrA proteases in children with cutaneous mastocytosis., PMID:30148508
Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex., PMID:27324898
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2., PMID:26340347
Inhibition of Human Pancreatic Cancer Cell Proliferation by Devil's Club Oplopanax horridus and Its Polyacetylene Bioactive Compound., PMID:26221768
Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer., PMID:25672320
Upregulation of mitochondrial protease HtrA2/Omi contributes to manganese-induced neuronal apoptosis in rat brain striatum., PMID:24657776
The identification and expression of the full-length HtrA2 gene from Penaeus monodon (black tiger shrimp)., PMID:24096090
The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats., PMID:23413020
Differential gene expression profiles may differentiate responder and nonresponder patients with rheumatoid arthritis for methotrexate (MTX) monotherapy and MTX plus tumor necrosis factor inhibitor combined therapy., PMID:22753658
Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death., PMID:20651226
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex., PMID:20614026
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases., PMID:20467442
Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration., PMID:19443712
Intracellular Abeta and C99 aggregates induce mitochondria-dependent cell death in human neuroglioma H4 cells through recruitment of the 20S proteasome subunits., PMID:19362074
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies., PMID:18800009
Arsenic trioxide sensitizes promonocytic leukemia cells to TNFalpha-induced apoptosis via p38-MAPK-regulated activation of both receptor-mediated and mitochondrial pathways., PMID:17673311
Expression analysis of proteases of Mycobacterium leprae in human skin lesions., PMID:17624714
Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria., PMID:16998592
Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria., PMID:16968707
The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells., PMID:16724231
Expression of the Staphylococcus aureus surface proteins HtrA1 and HtrA2 in Lactococcus lactis., PMID:15321674
Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1., PMID:15306124
Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex., PMID:14993223
Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA., PMID:14709600
Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions., PMID:14502242
Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy., PMID:12915451
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity., PMID:11803371
Activity-dependent regulation of alternative splicing patterns in the rat brain., PMID:10103073
For research use only. Not for human or drug use.
