Catalog No.
RHA40702
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
Doublecortin-like and CAM kinase-like 1, DCAMKL1, KIAA0369, Doublecortin-like kinase 1, DCLK1, Doublecortin domain-containing protein 3A, Serine/threonine-protein kinase DCLK1, DCDC3A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O15075
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1D47
Clinical significance of "S" isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody., PMID:40109216
DCLK1 in gastrointestinal cancer: A driver of tumor progression and a promising therapeutic target., PMID:40056091
Pleiotropic effects of DCLK1 in cancer and cancer stem cells., PMID:36250024
Preventive cancer stem cell-based vaccination modulates tumor development in syngeneic colon adenocarcinoma murine model., PMID:36040667
Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles., PMID:35738074
Oncogenic functions and clinical significances of DCLK1 isoforms in colorectal cancer: a systematic review and meta-analysis., PMID:35717205
Dietary antigens suppress the proliferation of type 2 innate lymphoid cells by restraining homeostatic IL-25 production., PMID:35523930
Duodenal cholinergic tuft cell number is increased in functional dyspepsia., PMID:35388579
Cytoplasmic expression of DCLK1-S, a novel DCLK1 isoform, is associated with tumor aggressiveness and worse disease-specific survival in colorectal cancer., PMID:34958000
Recent advances in drug delivery systems for targeting cancer stem cells., PMID:33532180
Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment., PMID:33348546
Morphological characterization of brush cells in the rat trachea., PMID:32933721
The prognostic value of leucine-rich repeat-containing G-protein (Lgr5) and its impact on clinicopathological features of colorectal cancer., PMID:32671503
Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis., PMID:32203220
DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers., PMID:31878090
Intestinal dysbacteriosis-induced IL-25 promotes development of HCC via alternative activation of macrophages in tumor microenvironment., PMID:31296243
Antibodies to a CA 19-9 Related Antigen Complex Identify SOX9 Expressing Progenitor Cells In Human Foetal Pancreas and Pancreatic Adenocarcinoma., PMID:30814526
Analysis of the clinical significance of DCLK1+ colorectal cancer using novel monoclonal antibodies against DCLK1., PMID:30174443
Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells., PMID:29604293
Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer., PMID:29577277
Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity., PMID:28570279
A novel antibody against cancer stem cell biomarker, DCLK1-S, is potentially useful for assessing colon cancer risk after screening colonoscopy., PMID:28414327
Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut., PMID:28375676
A novel double-targeted nondrug delivery system for targeting cancer stem cells., PMID:27994463
Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients., PMID:27881125
Overexpression of DCLK1 is predictive for recurrent disease in major salivary gland malignancies., PMID:27470117
[Cancer stemness and circulating tumor cells]., PMID:25985635
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma., PMID:25605241
DCLK1 is detectable in plasma of patients with Barrett's esophagus and esophageal adenocarcinoma., PMID:25283374
Characterization of anoikis-resistant cells in mouse colonic epithelium., PMID:23629020
Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin., PMID:23374535
Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis., PMID:22605579
Gastric tuft cells express DCLK1 and are expanded in hyperplasia., PMID:21688022
Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells., PMID:21183658
Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas., PMID:20522640
DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization., PMID:11124993
For research use only. Not for human or drug use.
