Catalog No.
RHA23301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
NCAN, CSPG3, Neurocan core protein, NEUR, Chondroitin sulfate proteoglycan 3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O14594
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1D19
CSF levels of brain-derived proteins correlate with brain ventricular volume in cognitively healthy 70-year-olds., PMID:39668376
CSF protein ratios with enhanced potential to reflect Alzheimer's disease pathology and neurodegeneration., PMID:38350954
Exploring the Diagnosis and Profile of Cannabis Allergy., PMID:30273677
Neuroanatomical characterization of perineuronal net components in the human cochlear nucleus and superior olivary complex., PMID:30025262
Bevacizumab reduces neurocan content and gene expression in newborn rat retina in vitro., PMID:25061112
The diagnostic performance of allergen-molecules in comparison to allergen-extracts., PMID:21973104
Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord., PMID:20534825
NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury., PMID:19604403
Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration., PMID:18385092
Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes., PMID:15968632
Lesion-induced differential expression and cell association of Neurocan, Brevican, Versican V1 and V2 in the mouse dorsal root entry zone., PMID:15896911
Axon behaviour at Schwann cell - astrocyte boundaries: manipulation of axon signalling pathways and the neural adhesion molecule L1 can enable axons to cross., PMID:15355310
Developmental changes of aggrecan, versican and neurocan in the retina and optic nerve., PMID:15336497
Expression of phosphacan and neurocan during early development of mouse retinofugal pathway., PMID:15283989
Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells., PMID:15208358
Altered neurotrophin receptor function in the developing prefrontal cortex leads to adult-onset dopaminergic hyperresponsivity and impaired prepulse inhibition of acoustic startle., PMID:15050860
Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures., PMID:14637091
Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro., PMID:12821372
Accumulation of neurocan, a brain chondroitin sulfate proteoglycan, in association with the retinal vasculature in RCS rats., PMID:12601056
Limited growth of severed CNS axons after treatment of adult rat brain with hyaluronidase., PMID:12478611
Developmentally regulated expression of brain-specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the postnatal rat hippocampus., PMID:11702233
Inhibitory effects of neurocan and phosphacan on neurite outgrowth from retinal ganglion cells in culture., PMID:11431463
Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury., PMID:11425904
Expression of brain specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the developing and adult hippocampus of Ihara's epileptic rats., PMID:11292447
Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R., PMID:11077416
Upregulated expression of neurocan, a nervous tissue specific proteoglycan, in transient retinal ischemia., PMID:10937593
Characterization of the L1-neurocan-binding site. Implications for L1-L1 homophilic binding., PMID:10934197
Coordinate regulation of cadherin and integrin function by the chondroitin sulfate proteoglycan neurocan., PMID:10851024
Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice., PMID:10793198
Neurocan is upregulated in injured brain and in cytokine-treated astrocytes., PMID:10729323
Distinct spatial and temporal distributions of aggrecan and versican in the embryonic chick heart., PMID:10589023
Identification of a nervous tissue-specific chondroitin sulfate proteoglycan, neurocan, in developing rat retina., PMID:10476802
Integrin and neurocan binding to L1 involves distinct Ig domains., PMID:10455125
Two types of brain chondroitin sulfate proteoglycan: their distribution and possible functions in the rat embryo., PMID:9809586
The core protein of the chondroitin sulfate proteoglycan phosphacan is a high-affinity ligand of fibroblast growth factor-2 and potentiates its mitogenic activity., PMID:9705269
Immunocytochemical localization and biochemical characterization of large proteoglycans in developing rat bone., PMID:9680765
Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican., PMID:9642104
Occurrence of a N-terminal proteolytic fragment of neurocan, not a C-terminal half, in a perineuronal net in the adult rat cerebrum., PMID:9593817
Transient compartmental expression of neurocan in the developing striatum of the rat., PMID:9512005
Mapping of a defined neurocan binding site to distinct domains of tenascin-C., PMID:9341124
Identification of monoclonal antibody At5 as a new member of HNK-1 antibody family: the reactivity with myelin-associated glycoprotein and with two brain-specific proteoglycans, phosphacan and neurocan., PMID:9016838
Structural and electron microscopic analysis of neurocan and recombinant neurocan fragments., PMID:8663259
TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM., PMID:8663515
Chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of nervous tissue: developmental changes of neurocan and phosphacan., PMID:7595522
Chondroitin sulfate proteoglycans in the developing cerebral cortex: the distribution of neurocan distinguishes forming afferent and efferent axonal pathways., PMID:7636035
Distribution of a brain-specific proteoglycan, neurocan, and the corresponding mRNA during the formation of barrels in the rat somatosensory cortex., PMID:7620606
Immunological identification of two proteoglycan fragments derived from neurocan, a brain-specific chondroitin sulfate proteoglycan., PMID:7849571
Developmentally regulated expression of a brain specific species of chondroitin sulfate proteoglycan, neurocan, identified with a monoclonal antibody IG2 in the rat cerebrum., PMID:8052408
The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth., PMID:7513709
Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue., PMID:7512960
For research use only. Not for human or drug use.
