Catalog No.
YHC19901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln639-Thr778
Predicted molecular weight
43.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P06400
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
pRb, p110-RB1, Retinoblastoma-associated protein, Rb, p105-Rb, RB1, pp110
Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems., PMID:40514658
Targeting anti-apoptosis as a therapeutic strategy in neuroendocrine neoplasms., PMID:40512124
Integrating Aggressive-Variant Prostate Cancer-Associated Tumor Suppressor Gene Status with Clinical Variables to Refine Prognosis and Predict Androgen Receptor Pathway Inhibitor Response in Metastatic Hormone-Sensitive Setting., PMID:40508118
SLIT/ROBO Pathway and Prostate Cancer: Gene and Protein Expression and Their Prognostic Values., PMID:40508075
DNA damage response inhibition is an early event in cadmium-induced breast carcinogenesis., PMID:40505819
Defining CDK12 as a tumor suppressor and therapeutic target in mouse models of tubo-ovarian high-grade serous carcinoma., PMID:40504161
Insights into retinoblastoma pathogenesis: unraveling RB1, N-MYC and miRNA profiles., PMID:40499938
Ginsenoside Rb1 inhibits chronic stress-induced colorectal cancer via regulating glycolysis and β2-AR/CREB1 signaling pathway., PMID:40498670
Eribulin inhibits tumor growth of two novel patient-derived xenograft models of Merkel cell carcinoma., PMID:40494738
Ageing Signatures and Disturbed Muscle Regeneration in Muscle Proteome of Inclusion Body Myositis., PMID:40485189
Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance., PMID:40473819
Case Report: A novel germline donor splicing site mutation of RB1 gene in a Chinese Tibetan pedigree with familial retinoblastoma., PMID:40463882
Exceptional Long-term Response to Immunotherapy in an African American Man With STK11/TP53/RB1-Mutated Metastatic Lung Adenocarcinoma., PMID:40448514
Detection of hotspot mutations in oral cancer through Ion AmpliSeq™ cancer hotspot panel v.2.0: A circulating DNA fragmentomics approach in the Northeast Indian population., PMID:40440828
First-line serplulimab plus chemotherapy in extensive-stage small-cell lung cancer: Updated results and biomarker analysis from the ASTRUM-005 randomized clinical trial., PMID:40440184
Mutational analysis and protein expression of PI3K/AKT pathway in four mucinous cystadenocarcinoma of the breast., PMID:40437613
BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress., PMID:40436896
Infection with the Endonuclear Symbiotic Bacterium Holospora obtusa Reversibly Alters Surface Antigen Expression of the Host Paramecium caudatum., PMID:40431163
Dedifferentiated Solitary Fibrous Tumor: A Clinicopathologic, Immunohistochemical, and Molecular Characterization of 25 Cases., PMID:40420616
Pancreatic adenocarcinoma in a patient with a germline RB1 pathogenic variant., PMID:40418431
Genomics-led approach to drug testing in models of undifferentiated pleomorphic sarcoma., PMID:40415599
BaZiBuShen inhibition of oocyte ferroptosis in primordial follicles through activation of NF2-YAP pathway for the treatment of chemotherapy-induced premature ovarian insufficiency., PMID:40412775
SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma., PMID:40402518
RB1 and p53 are diagnostic markers for treatment-related neuroendocrine prostate cancer: a clinical and pathological analysis of 23 cases., PMID:40401001
A proteotranscriptomic approach to dissect the molecular landscape of human retinoblastoma., PMID:40395327
APOBEC3 mutagenesis drives therapy resistance in breast cancer., PMID:40379787
NSP6 regulates calcium overload-induced autophagic cell death and is regulated by KLHL22-mediated ubiquitination., PMID:40373961
Outcomes After Radiation for Oligoprogressive Disease Sites in Patients With EGFR-Mutant Lung Cancer Treated With Osimertinib., PMID:40373257
Radiation-Induced Synchronous Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Clinical, Morphological, and Genetic Insights., PMID:40362680
Plasmacytoid urothelial carcinoma of the urinary bladder: A single institution experience with focus on next-generation sequencing (NGS) and PD-L1 immunohistochemistry., PMID:40349989
An exploration of the protective effects of Ginsenoside Rb1 against acute lung injury using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experiments., PMID:40347881
Ocular manifestations in pediatric tumor suppressor gene mutations: a case series and literature review of RB1, NF1, NF2, VHL, and TSC., PMID:40346602
Oncocytic subtype of well differentiated neuroendocrine tumor: clinicopathologic and molecular associations of a cohort diagnosed on fine needle aspiration (FNA)., PMID:40345926
Drosha: a new tumor suppressor in pineoblastoma., PMID:40345854
Modulation of adipose tissue phenotype and longevity-related gene expression by nuclear factor E2-related factor 2 knockdown in 3T3-L1 cells., PMID:40341662
Guiding precision medicine strategy for intravenous ginsenosides via pharmacokinetic-informed bioinformatic approaches: a study on XueShuanTong., PMID:40339549
Retinoblastoma: Molecular Evaluation of Tumor Samples, Aqueous Humor, and Peripheral Blood Using a Next-Generation Sequence Panel., PMID:40332023
Nutraceuticals Targeting Cannabinoid Receptor 1 and Transient Receptor Potential Vanilloid 1 for Pain Relief: A Computational Screening Approach., PMID:40330338
Conserved Local Structural Motifs in Glycoside Hydrolase Families Facilitate the Discovery of Functional Enzymes., PMID:40324897
Delving Into Retinoblastoma Genetics: Discovery of Novel Mutations and Their Clinical Impact: Retrospective Cohort Study., PMID:40317918
Renshenjian decoction alleviates diabetes via HIF-1α/SPTLC2 pathway by targeting ceramide synthesis., PMID:40316155
Cell cycle duration determines oncogenic transformation capacity., PMID:40307557
An organoid library unveils subtype-specific IGF-1 dependency via a YAP-AP1 axis in human small cell lung cancer., PMID:40307487
Dual Role of CRABP2 in Colorectal Cancer: Oncogenesis via Nuclear RB1 and Cytoplasmic AFG3L2/SLC25A39 Axis, While Limiting Liver Metastasis through Cytoplasmic AFG3L2/PINK1/Parkin-Mediated Mitophagy., PMID:40305785
Association of Androgen Receptor Expression With Tumor Immune Landscape and Treatment Outcomes of Patients With Breast Cancer., PMID:40294352
Primary de novo Epidermal Growth Factor Receptor Mutant Small Cell Lung Carcinomas: Clinicopathological Study of a Rare Entity Presenting in Treatment-Naïve Setting with Review of Literature., PMID:40289562
Ginsenoside Rb1 Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway., PMID:40283937
MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues., PMID:40279415
Folliculin (FLCN) in Thyroid Tumors: Incidence, Significance, and Role as a Driver Gene and Secondary Alteration., PMID:40277780
SLAYER: a computational framework for identifying synthetic lethal interactions through integrated analysis of cancer dependencies., PMID:40276038
For research use only. Not for human or drug use.
