Catalog No.
YHC19101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser763-Lys956
Predicted molecular weight
23.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P06213
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
INSR, IR, CD220, Insulin receptor
Rare Homozygous Variants in INSR and NFXL1 Are Associated with Severe Treatment-Resistant Psychosis., PMID:40430072
Case Report: The long-term effects of the empagliflozin therapy on glycemia and renal function in a patient with Rabson-Mendenhall syndrome caused by two heterozygous variants in INSR gene., PMID:40241988
Genetic determinants and clinical significance of circulating and tumor-specific levels of insulin-like growth factor binding protein 7 (IGFBP7) in a Swedish breast cancer cohort., PMID:40230015
Ginsenoside Rk1 inhibits the malignant progression of lung cancer by inactivating the INSR/PI3K/AKT pathway., PMID:40187002
Genetic variants in insulin, leptin, and their receptors are associated with overweight in a Brazilian asthma cohort., PMID:40132274
Investigation of associations between polycystic ovary syndrome and INSR gene polymorphisms rs2059806 and rs2252673., PMID:40105555
[Analysis of novel mutations in the insulin receptor gene of a family with type A insulin resistance syndrome]., PMID:40050092
IGF1R/ARRB1 Mediated Regulation of ERK and cAMP Pathways in Response to Aβ Unfolds Novel Therapeutic Avenue in Alzheimer's Disease., PMID:39969678
Assessment of Changes in the Expression of Genes Involved in Insulin Signaling and Glucose Transport in Leukocytes of Women with Gestational Diabetes During Pregnancy and in the Postpartum Period., PMID:39684804
Functional analysis of fibroblasts and macrophages in head and neck paragangliomas., PMID:39619326
Association between insulin-associated gene polymorphisms and new-onset diabetes mellitus in statin-treated patients., PMID:39614667
Association Between NsiI and PmLI Insulin Receptors on the Development of Polycystic Ovarian Syndrome., PMID:39551955
A series of genetically confirmed congenital lipodystrophy and diabetes in adult southern Indian patients., PMID:39550450
Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells., PMID:39419341
The Impact of Dibutyl Phthalate on Insulin Signaling in Human Skeletal Muscle Cells., PMID:39327244
Metabolic and hormonal profiling in polycystic ovarian syndrome: insights into INSR gene variations., PMID:39287700
Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility., PMID:39201651
Agonist Discovery for Membrane Proteins on Live Cells by Using DNA-encoded Libraries., PMID:39171830
Using site-directed mutagenesis to further the understanding of insulin receptor-insulin like growth factor-1 receptor heterodimer structure., PMID:39033666
Insulin receptor orchestrates kidney antibacterial defenses., PMID:38976738
Alterations to metabolic hormones in amyotrophic lateral sclerosis and frontotemporal dementia postmortem human tissue., PMID:38917432
Marine-Derived Phosphoeleganin and Its Semisynthetic Derivative Decrease IL6 Levels and Improve Insulin Signaling in Human Hepatocellular Carcinoma Cells., PMID:38892230
Research into how carvacrol and metformin affect several human proteins in a hyperglycemic condition: A comparative study in silico and in vitro., PMID:38880320
The brain insulin receptor gene network and associations with frailty index., PMID:38752921
A Novel Mutation in the INSR Gene Causes Severe Insulin Resistance and Rabson-Mendenhall Syndrome in a Paraguayan Patient., PMID:38542117
Activation of the insulin receptor by insulin-like growth factor 2., PMID:38521788
The interaction between magnesium intake, the genetic variant INSR rs1799817 and colorectal cancer risk in a Korean population: a case-control study., PMID:38389245
Type A insulin resistance syndrome due to a novel heterozygous c.3486_3503del (p.Arg1163_Ala1168del) INSR gene mutation in an adolescent girl and her mother., PMID:38289143
Changes in Expression of Key Genes in Alzheimer's Disease: A Specific Brain Tissue Change., PMID:38267766
Impact of INSR (rs2229429) G>A genetic polymorphism on response to exogenous insulin in type 1 diabetic Iraqi patients., PMID:40023858
Association between diabetes and stress-induced hyperglycemia with skeletal muscle gene expression of INSR in critically ill patients: A prospective cohort study., PMID:37863470
Can obesity exacerbate hyperinsulinaemia in the presence of the mutation of an insulin receptor gene?, PMID:37717597
Uterine inflammatory myofibroblastic tumor with THBS1-INSR fusion., PMID:37156213
Diazoxide-unresponsive Hyperinsulinemic Hypoglycaemia in a Preterm Infant with Heterozygous Insulin Receptor Gene Mutation., PMID:37074094
Associations between heredity, height, BMI, diabetes mellitus type 1 or 2 and gene variants in the insulin receptor (INSR) gene in patients with schizophrenia., PMID:36931226
INSR novel mutations identified in a Chinese family with severe INSR-related insulin resistance syndromes: A case report., PMID:36626508
Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes., PMID:36408724
Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology., PMID:36189587
Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart., PMID:35786404
Excess 11-Oxygenated Androgens in Women With Severe Insulin Resistance Are Mediated by Adrenal Insulin Receptor Signaling., PMID:35696182
Mechanism of INSR clustering with insulin activation and resistance revealed by super-resolution imaging., PMID:35579582
Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling., PMID:35074483
Syndrome of Congenital Insulin Resistance Caused by a Novel INSR Gene Mutation., PMID:34965699
Insulin-Responsive Transcription Factors., PMID:34944530
Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance., PMID:34921686
Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood-Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells., PMID:34811625
The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network., PMID:34732766
Long-Term Effects of Metreleptin in Rabson-Mendenhall Syndrome on Glycemia, Growth, and Kidney Function., PMID:34718628
Structures and interactions of insulin-like peptides from cone snail venom., PMID:34661928
Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation., PMID:34644569
For research use only. Not for human or drug use.
