Catalog No.
RHE45801
Species reactivity
Human, Mouse, Rat, Cow, Dog, Monkey, Zebrafish
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
c-Jun N-terminal kinase 3, JNK1, JNK2, JNK3, JNK3 alpha protein kinase, JNK3A, MAP kinase 10, MAP kinase p49 3F12, MAPK 10, MAPK10, JNK1/2/3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P45983, P45984, P53779
Applications
IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4 ℃ short term (1-2 weeks).
Store at -20 ℃ 12 months.
Store at -80 ℃ long term.
Clone ID
R1C15
PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion., PMID:40048154
IQGAP1 promotes early B cell development, is essential for the development of marginal zone (MZ) B cells, and is critical for both T-dependent and T-independent antibody responses., PMID:39585462
JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL., PMID:39570282
Correction: The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation., PMID:39392382
Flavonoids with Anti-Angiogenesis Function in Cancer., PMID:38611849
Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms., PMID:38515057
Arrestin-3-Dependent Activation of c-Jun N-Terminal Kinases (JNKs)., PMID:37668419
Screening Kinase-Dependent Phosphorylation of Key Metabolic Reprogramming Regulators., PMID:37258766
c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor that regulates early retinal development., PMID:36434388
Tumor Necrosis Factor-α-Induced C-C Motif Chemokine Ligand 20 Expression through TNF Receptor 1-Dependent Activation of EGFR/p38 MAPK and JNK1/2/FoxO1 or the NF-κB Pathway in Human Cardiac Fibroblasts., PMID:36012347
IL-38, a potential therapeutic agent for lupus, inhibits lupus progression., PMID:35776155
CARD9 Mediates Pancreatic Islet Beta-Cell Dysfunction Under the Duress of Hyperglycemic Stress., PMID:35362297
JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth., PMID:35347634
Toll-like receptor 2 and 6 agonist fibroblast-stimulating lipopeptide increases expression and secretion of CXCL1 and CXCL2 by uveal melanocytes., PMID:35074346
Fab Fragment of Immunoglobulin Y Modulates NF-κB and MAPK Signaling through TLR4 and αVβ3 Integrin and Inhibits the Inflammatory Effect on R264.7 Macrophages., PMID:34337939
Upregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts., PMID:34234507
The effect of biodegradable silk fibroin-based scaffolds containing glial cell line-derived neurotrophic factor (GDNF) on the corneal regeneration process., PMID:34119551
Cultured Human Uveal Melanocytes Express/secrete CXCL1 and CXCL2 Constitutively and Increased by Lipopolysaccharide via Activation of Toll-like Receptor 4., PMID:33979551
Fine particulate matter (PM2.5) promotes IgE-mediated mast cell activation through ROS/Gadd45b/JNK axis., PMID:33676788
Erythroid differentiation regulator 1 promotes wound healing by inducing the production of C‑C motif chemokine ligand 2 via the activation of MAP kinases in vitro and in vivo., PMID:33125115
Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo., PMID:32764489
Topical Application of 7,3',4'-Trihydroxyisoflavone Alleviates Atopic Dermatitis-Like Symptoms in NC/Nga Mice., PMID:31853913
ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells., PMID:31443721
Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in RAW264.7 cells., PMID:31148200
An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy., PMID:31086176
Pro-atherogenic proteoglycanase ADAMTS-1 is down-regulated by lauric acid through PI3K and JNK signaling pathways in THP-1 derived macrophages., PMID:30989556
Ultravist Induces the Expression of MCP-1 and VCAM-1 in IL-4-Stimulated HUVECs., PMID:30918133
Titanium dioxide nanotubes of defined diameter enhance mesenchymal stem cell proliferation via JNK- and ERK-dependent up-regulation of fibroblast growth factor-2 by T lymphocytes., PMID:30757966
Visfatin Promotes Wound Healing through the Activation of ERK1/2 and JNK1/2 Pathway., PMID:30463229
Combination Therapy with Low-Dose IVIG and a C1-esterase Inhibitor Ameliorates Brain Damage and Functional Deficits in Experimental Ischemic Stroke., PMID:29299869
Dual regulation of HMGB1 by combined JNK1/2-ATF2 axis with miR-200 family in nonalcoholic steatohepatitis in mice., PMID:29298863
Proinflammatory effects and mechanisms of calprotectin on human gingival fibroblasts., PMID:28643937
Cyclic peptide *CRRETAWAC* attenuates fibronectin-induced cytokine secretion of human airway smooth muscle cells by inhibiting FAK and p38 MAPK., PMID:28402030
ERK1 Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun Activity and Cell Transformation., PMID:28106280
JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts., PMID:28054591
αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor., PMID:27450452
Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells., PMID:27377703
JNK does not regulate meiotic progression in Xenopus oocytes: The strange case of pJNK and pERK., PMID:27297883
The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation., PMID:27203743
Suppression of IL-8-Src signalling axis by 17β-estradiol inhibits human mesenchymal stem cells-mediated gastric cancer invasion., PMID:26945908
JNK in spinal cord facilitates bone cancer pain in rats through modulation of CXCL1., PMID:26838746
Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells., PMID:26716417
SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response., PMID:26619119
Leptin Promotes cPLA₂ Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade., PMID:26593914
Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells., PMID:26514923
E-cadherin knockdown increases β-catenin reducing colorectal cancer chemosensitivity only in three-dimensional cultures., PMID:26316041
Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection., PMID:26046590
SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL., PMID:25946330
Chrysin inhibits tumor promoter-induced MMP-9 expression by blocking AP-1 via suppression of ERK and JNK pathways in gastric cancer cells., PMID:25875631
Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor., PMID:25784649
For research use only. Not for human or drug use.
