Catalog No.
YHC15601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro2-Gln81
Predicted molecular weight
10.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05204
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Non-histone chromosomal protein HMG-17, High mobility group nucleosome-binding domain-containing protein 2, HMG17, HMGN2
Characterization of cytokine treatment on human pancreatic islets by top-down proteomics., PMID:40463221
Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning., PMID:40406620
High mobility group protein N2 inhibits the progression of hepatocellular carcinoma and the related molecular mechanisms., PMID:39676764
[Corrigendum] Nucleosome‑binding protein HMGN2 exhibits antitumor activity in human SaO2 and U2‑OS osteosarcoma cell lines., PMID:39422077
An evolutionarily distinct Hmgn2 variant influences shape recognition in Medaka Fish., PMID:39179658
A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma., PMID:38225273
Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins., PMID:37950483
HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture for seasonal allergic rhinitis., PMID:37869664
Development of multifunctional synthetic nucleosomes to interrogate chromatin-mediated protein interactions., PMID:37134166
Novel biomarkers predict prognosis and drug-induced neuroendocrine differentiation in patients with prostate cancer., PMID:36686485
A pilot study on identifying gene signatures as markers for predicting patient response to antiseizure medications., PMID:36658410
Expression, tumor immune infiltration, and prognostic impact of HMGs in gastric cancer., PMID:36568211
Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins., PMID:36435799
Central gene transcriptional regulatory networks shaping monocyte development in bone marrow., PMID:36304450
HMGN2 represses gene transcription via interaction with transcription factors Lef-1 and Pitx2 during amelogenesis., PMID:35872015
Recombinant jurkat cells (HMGN2-T cells) secrete cytokines and inhibit the growth of tumor cells., PMID:35861945
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin., PMID:35761366
H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors., PMID:35197580
Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome., PMID:34946949
Lysine succinylation on non-histone chromosomal protein HMG-17 (HMGN2) regulates nucleosomal DNA accessibility by disrupting the HMGN2-nucleosome association., PMID:34458839
The regulatory effect of acetylation of HMGN2 and H3K27 on pyocyanin-induced autophagy in macrophages by affecting Ulk1 transcription., PMID:34278675
Prolactin Drives a Dynamic STAT5A/HDAC6/HMGN2 Cis-Regulatory Landscape Exploitable in ER+ Breast Cancer., PMID:33589921
Prognostic value of HMGN family expression in acute myeloid leukemia., PMID:33467898
High mobility group nucleosomal binding 2 reduces integrin α5/β1-mediated adhesion of Klebsiella pneumoniae on human pulmonary epithelial cells via nuclear factor I., PMID:33034909
Transcriptomic analysis of peripheral blood mononuclear cells in head and neck squamous cell carcinoma patients., PMID:32892371
Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair., PMID:32152397
Exogenous HMGN2 inhibits the migration and invasion of osteosarcoma cell lines., PMID:35117527
FAM96B inhibits the senescence of dental pulp stem cells., PMID:32039527
The interactome and proteomic responses of ALKBH7 in cell lines by in-depth proteomics analysis., PMID:31889914
Maintenance of active chromatin states by HMGN2 is required for stem cell identity in a pluripotent stem cell model., PMID:31831052
Nucleosome binding peptide presents laudable biophysical and in vivo effects., PMID:31810135
High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis., PMID:31699896
HMGN2 regulates non-tuberculous mycobacteria survival via modulation of M1 macrophage polarization., PMID:31596045
High-throughput assessment of the antibody profile in ovarian cancer ascitic fluids., PMID:31428516
High-mobility group protein N2 induces autophagy by activating AMPK/ULK1 pathway and thereby boosts UPEC proliferation within bladder epithelial cells., PMID:30952427
Effect of HMGN2 on proliferation and apoptosis of MCF-7 breast cancer cells., PMID:30655878
Binding of HMGN proteins to cell specific enhancers stabilizes cell identity., PMID:30532006
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei., PMID:30021884
Non-histone nuclear protein HMGN2 differently regulates the urothelium barrier function by altering expression of antimicrobial peptides and tight junction protein genes in UPEC J96-infected bladder epithelial cell monolayer., PMID:29549670
Increased expression of high-mobility group nucleosomal-binding domain 2 protein in various tumor cell lines., PMID:29541221
HMGN2: An Antitumor Effector Molecule of γδT Cells., PMID:29401165
Evidence For Hmgn2 Involvement in Mouse Embryo Implantation and Decidualization., PMID:29216626
A Systematic Study of PLLA Aligned Nanofiber-Induced Differentiation of PC12 Cells Using mRNA-microRNAProtein Biomics Integrated Analyses., PMID:31251138
A simple and versatile system for the ATP-dependent assembly of chromatin., PMID:28982979
HMGN1 and 2 remodel core and linker histone tail domains within chromatin., PMID:28973435
[High Mobility Group Chromosomal Protein N2 Inhibit Cervical Cancer Transplanted in Nude Mice]., PMID:28598086
[The Role of HMGN2 in the Development of Periodontitis Dental Plaque]., PMID:28591948
Antibacterial mechanism of high-mobility group nucleosomal-binding domain 2 on the Gram-negative bacteria Escherichia coli., PMID:28471113
Nuclear protein HMGN2 attenuates pyocyanin-induced oxidative stress via Nrf2 signaling and inhibits Pseudomonas aeruginosa internalization in A549 cells., PMID:28408162
Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells., PMID:28035005
For research use only. Not for human or drug use.
