Catalog No.
YHC14601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly157
Predicted molecular weight
19.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05161
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interferon-induced 17 kDa protein, G1P2, hUCRP, Ubiquitin-like protein ISG15, IP17, UCRP, ISG15, Ubiquitin cross-reactive protein, Interferon-induced 15 kDa protein
Activity-Based Protein Profiling (ABPP) of Cellular DeISGylating Enzymes and Inhibitor Screening., PMID:40515982
Targeting USP18 overcomes acquired resistance in hepatocellular carcinoma by regulating NCOA4 deISGylation and ferroptosis., PMID:40514377
LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling., PMID:40495222
IFIT2-induced transcriptomic changes in Mycobacterium tuberculosis infected macrophages., PMID:40463504
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis., PMID:40462493
Differential regulation of STING expression and cisplatin sensitivity by autophagy in non-small cell lung cancer cells., PMID:40445433
Elucidating the chromatin-driven transcription regulatory networks response to Streptococcus agalactiae infection under low temperature in Nile tilapia., PMID:40441668
Mechanisms of USP18 specificity towards ISG15 revealed by paralog sequence analysis comparison., PMID:40436319
Proliferative arrest induces neuronal differentiation and innate immune responses in normal and Creutzfeldt-Jakob Disease agent (CJ) infected rat septal neurons., PMID:40434970
Virus-specific host responses and gene signatures following infection with major SARS-CoV-2 variants of concern: role of ZBP1 in viral clearance and lung inflammation., PMID:40416961
[Cucurbitacin B alleviates skin lesions and inflammation in a psoriasis mouse model by inhibiting the cGAS-STING signaling pathway]., PMID:40415622
Spermidine reduces ISGylation and enhances ISG15-USP18 interaction., PMID:40410283
HERC5-mediated ISGylation of SARS-CoV-2 nsp8 facilitates its degradation and inhibits viral replication., PMID:40409630
Potential drug targets for peripheral artery disease identified through Mendelian randomization analysis., PMID:40394637
Conceptus signaling markers in immune cells enhance pregnancy prediction in beef cattle., PMID:40394099
Transcriptomic analysis of differential expression between surviving and nonsurviving patients infected by the SARS-CoV-2 Delta variant., PMID:40374692
Interferon-induced protein ISG15 in the central nervous system, quo vadis?, PMID:40353372
Verification of biological markers of subacute cutaneous lupus erythematosus via TMT labelling proteomics combined with transcriptome data., PMID:40323689
Type II interferons activate MHC-I pathway to enhance antigen presentation of grass carp reovirus VP35 DNA vaccine., PMID:40320154
Single-cell RNA sequencing reveals a fibroblast gene signature that promotes T-cell infiltration in muscle-invasive bladder cancer., PMID:40319103
A novel homozygous ISG15 missense variant leads to severe inflammatory skin lesions, interstitial pneumonia, and basal ganglia calcifications in a Chinese infant with ISG15 deficiency., PMID:40318816
Thymoquinone enhances efficacy of cervical Cancer therapeutic vaccines via modulating CD8+ T cells., PMID:40316484
Chasing Virus Replication and Infection: PAMP-PRR Interaction Drives Type I Interferon Production, Which in Turn Activates ISG Expression and ISGylation., PMID:40284971
Insight into mechanism of ALKBH5-mediated N6-methyladenosine (m6A) regulating porcine epidemic diarrhea virus infection in IPEC-J2 cells., PMID:40280045
LDHA-lactate axis modulates mitophagy inhibiting CSFV replication., PMID:40265937
Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling., PMID:40260261
Anti-SARS-CoV-2 Small Molecule Targeting of Oxysterol-Binding Protein (OSBP) Activates Cellular Antiviral Innate Immunity., PMID:40255103
The first trimester human placenta responds to Zika virus infection inducing an interferon (IFN) and antiviral interferon stimulated gene (ISG) response., PMID:40253335
NLRC3 regulates RIP2, STING, TBK1, and TRAF6 mediated type I IFN signaling and inflammatory response in large yellow croaker Larimichthys crocea., PMID:40252745
Molecular Interplay of ISG15/ISGylation in Neuropathologies., PMID:40231507
The embryonic DPPA3 gene stimulates the expression of pregnancy-related genes in bovine endometrial cells., PMID:40222672
Cohort-based pan-cancer analysis and experimental studies reveal ISG15 gene as a novel biomarker for prognosis and immunotherapy efficacy prediction., PMID:40208307
Proteome profiling of the lung tissues of the mice co-infected with H9N2 influenza A virus and Pseudomonas aeruginosa., PMID:40187293
Chronic sleep deprivation promotes experimental autoimmune uveitis through STAT1 phosphorylation, ISG15 expression and enhanced pathogenicity of macrophages., PMID:40163942
Identification of aberrant interferon-stimulated gene associated host responses potentially linked to poor prognosis in COVID-19 during the Omicron wave., PMID:40155905
Rescue of a unique ovine parainfluenza virus type 3 strain via Red/ET assembly., PMID:40147559
Sustained release of ubiquitin-like protein ISG-15 enhances tendon-to-bone healing following anterior cruciate ligament reconstruction in a mouse model., PMID:40144394
ATG16L1 WD domain and linker regulates lipid trafficking to maintain plasma membrane integrity to limit influenza virus infection., PMID:40143422
BRCA1 regulates glucose and lipid metabolism in diabetes mellitus with metabolic dysfunction-associated steatotic liver disease via the PI3K/Akt signaling pathway., PMID:40138287
ISG15 Enhances the Activity of γ-Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet-Promoted Hepatocellular Carcinoma., PMID:40126377
ISG15 depletion enhances oHSV-1 replication and antitumor efficacy in oral squamous cell carcinoma., PMID:40121989
ISGylation: is our genome yearning for such a modification?, PMID:40103488
Hexokinase 2 promotes ISGylation of Acyl-CoA synthetase long-chain family member 4 in sepsis-induced microglia cells., PMID:40086696
Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming., PMID:40069143
Mpox virus poxin-schlafen fusion protein suppresses innate antiviral response by sequestering STAT2., PMID:40066622
E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma., PMID:40045362
Predicting interactome networks of up/down regulated proteins and drug-gene interaction analysis associated with peri-implantitis., PMID:40028501
Analysis of differential transcriptome expression reveals that ISG15 provides support for embryo development by promoting angiogenesis in porcine mesometrium., PMID:40024418
Gene Expression Signatures of Porcine Bone Marrow-Derived Antigen-Presenting Cells Infected with Classical Swine Fever Virus., PMID:40006915
The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses., PMID:39998221
For research use only. Not for human or drug use.
