A Computationally Designed Prefusion Stabilized Human Metapneumovirus Fusion Protein Vaccine Antigen Elicited a Potent Neutralization Response., PMID:40432132
Clinical Insights and Advancements in Human Metapneumovirus Management and Prognosis., PMID:40351504
A tumor-binding antibody with cross-reactivity to viral antigens., PMID:40009215
Fumarprotocetraric acid and geraniin were identified as novel inhibitors of human respiratory syncytial virus infection in vitro., PMID:39776441
Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus., PMID:39550381
Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer., PMID:39054318
Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice., PMID:38898106
VLPs generated by the fusion of RSV-F or hMPV-F glycoprotein to HIV-Gag show improved immunogenicity and neutralizing response in mice., PMID:38641492
A tale of two fusion proteins: understanding the metastability of human respiratory syncytial virus and metapneumovirus and implications for rational design of uncleaved prefusion-closed trimers., PMID:38496645
A general computational design strategy for stabilizing viral class I fusion proteins., PMID:38351001
A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein., PMID:38117059
Structural characterization of M8C10, a neutralizing antibody targeting a highly conserved prefusion-specific epitope on the metapneumovirus fusion trimerization interface., PMID:38032197
Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus., PMID:37738240
Structural basis for respiratory syncytial virus and human metapneumovirus neutralization., PMID:37544710
Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode., PMID:37516111
Neutralising antibodies against human metapneumovirus., PMID:37499668
The HRA2pl fusion peptide exerts in vitro antiviral activity against human respiratory paramyxoviruses and pneumoviruses., PMID:37153148
A general computational design strategy for stabilizing viral class I fusion proteins., PMID:36993551
Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus., PMID:36130517
A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein., PMID:36003370
Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein., PMID:35944529
Elicitation of pneumovirus-specific B cell responses by a prefusion-stabilized respiratory syncytial virus F subunit vaccine., PMID:35731888
Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus., PMID:35696580
Profiling of hMPV F-specific antibodies isolated from human memory B cells., PMID:35538099
Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins., PMID:35288548
Avian Cell Line DuckCelt®-T17 Is an Efficient Production System for Live-Attenuated Human Metapneumovirus Vaccine Candidate Metavac®., PMID:34696298
Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses., PMID:34551978
Structure, Immunogenicity, and Conformation-Dependent Receptor Binding of the Postfusion Human Metapneumovirus F Protein., PMID:34160259
Sendai Virus-Vectored Vaccines That Express Envelope Glycoproteins of Respiratory Viruses., PMID:34072332
Antibody recognition of the Pneumovirus fusion protein trimer interface., PMID:33035266
Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice., PMID:32007293
Antibody Epitopes of Pneumovirus Fusion Proteins., PMID:31849961
Characterization of potent RSV neutralizing antibodies isolated from human memory B cells and identification of diverse RSV/hMPV cross-neutralizing epitopes., PMID:31402751
A Potent Neutralizing Site III-Specific Human Antibody Neutralizes Human Metapneumovirus In Vivo., PMID:31292250
Antigenic and sequence variability of the human respiratory syncytial virus F glycoprotein compared to related viruses in a comprehensive dataset., PMID:30292456
Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins., PMID:29470533
Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses., PMID:29217660
Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein., PMID:29142300
Effectiveness of Palivizumab in High-risk Infants and Children: A Propensity Score Weighted Regression Analysis., PMID:28709160
A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge., PMID:28605636
Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus., PMID:28134915
Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors., PMID:28111638
Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation., PMID:27611367
A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV., PMID:27224013
Novel Respiratory Syncytial Virus-Like Particle Vaccine Composed of the Postfusion and Prefusion Conformations of the F Glycoprotein., PMID:27030590
Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates., PMID:26772634
Human Metapneumovirus., PMID:26104361
Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells., PMID:26063431
The Pneumovirinae fusion (F) protein: A common target for vaccines and antivirals., PMID:25738581
Adjuvant effect of the human metapneumovirus (HMPV) matrix protein in HMPV subunit vaccines., PMID:25519171