Catalog No.
YHD45801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr311-Ser382
Predicted molecular weight
36.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21453
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
S1PR1, Sphingosine 1-phosphate receptor 1, Endothelial differentiation G-protein coupled receptor 1, EDG1, CHEDG1, Sphingosine 1-phosphate receptor Edg-1, S1P1, S1P receptor Edg-1, S1P receptor 1, CD363
Surface CD69-Negative CD4 and CD8 Bone Marrow-Resident Human Memory T Cells., PMID:40375826
A guide to selecting high-performing antibodies for S1PR1 (UniProt ID: P21453) for use in western blot, immunoprecipitation, and immunofluorescence., PMID:40291769
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage., PMID:40266369
Identification of the potential role of S1PR1 in adult moyamoya disease based on multiple bioinformatics analysis and experimental verification., PMID:40105149
S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity., PMID:39979282
CD44v, S1PR1, HER3, MET and cancer-associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb., PMID:39757718
S1PR1 suppresses lung adenocarcinoma progression through p-STAT1/miR-30c-5 p/FOXA1 pathway., PMID:39551792
Evaluation of proximod, a selective agonist of sphingosine-1-phosphate receptor-1, in healthy volunteers and patients with rheumatoid arthritis: a phase 1, double-blind, randomised, placebo-controlled, ascending dose trial., PMID:39454617
S1PR1 mediates Th17 cell migration from the thymus to the skin in health and disease., PMID:39380990
Sphingosine-1 phosphate receptor 1 (S1PR1) expression maintains stemness of acute myeloid leukemia stem cells., PMID:39111385
Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist., PMID:39030171
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid., PMID:38907081
Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis., PMID:38855867
Mitigation of myocardial ischemia/reperfusion-induced chronic heart failure via Shexiang Baoxin Pill-mediated regulation of the S1PR1 signaling pathway., PMID:38569296
The coumarin component isofraxidin targets the G-protein-coupled receptor S1PR1 to modulate IL-17 signaling and alleviate ulcerative colitis., PMID:38479159
S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes., PMID:38194271
InfluenZing Lung Fibrosis: Reinforcing Endothelial Surface Expression of S1PR1 to Attenuate Post-Acute Respiratory Distress Syndrome Lung Remodeling., PMID:37967249
Quantitative Analysis of S1PR1 Expression in the Postmortem Multiple Sclerosis Central Nervous System., PMID:37882753
CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus., PMID:37858140
S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway., PMID:37828220
HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus., PMID:37762169
Force-Loaded Cementocytes Regulate Osteoclastogenesis via S1P/S1PR1/Rac1 Axis., PMID:37735908
Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1., PMID:37220855
Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment., PMID:37170724
S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720., PMID:37048053
Dialogue between VE-Cadherin and Sphingosine 1 Phosphate Receptor1 (S1PR1) for Protecting Endothelial Functions., PMID:36835432
S1PR1 modulators in multiple sclerosis: Efficacy, safety, comparison, and chemical structure insights., PMID:36758307
S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma., PMID:36600310
Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients., PMID:36555755
Knockdown of BATF3 Inhibits Gastric Cancer Cell Growth and Radioresistance via S1PR1/STAT3 Pathway., PMID:36261191
New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1., PMID:36209115
S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission., PMID:36071219
S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression., PMID:36068200
Structural insights into sphingosine-1-phosphate receptor activation., PMID:35412894
Downregulation of miR-33a/b and miR-181a contributes to recurrent pregnancy loss by upregulating S1PR1 and repressing regulatory T cell differentiation., PMID:35325806
In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P1) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P1 Receptor Modulator., PMID:35163112
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate., PMID:35136060
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis., PMID:35077170
Radiosynthesis and evaluation of a fluorine-18 radiotracer [18F]FS1P1 for imaging sphingosine-1-phosphate receptor 1., PMID:35029272
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis., PMID:34873055
Tyrosine phosphorylation of S1PR1 leads to chaperone BiP-mediated import to the endoplasmic reticulum., PMID:34652421
Characterisation of peri-implantation endometrial Treg and identification of an altered phenotype in recurrent pregnancy loss., PMID:34552206
Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition., PMID:34526663
Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4., PMID:34504486
Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein., PMID:34407633
SMYD3 promotes hepatocellular carcinoma progression by methylating S1PR1 promoters., PMID:34301921
Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy., PMID:34068927
The targetable nanoparticle BAF312@cRGD-CaP-NP represses tumor growth and angiogenesis by downregulating the S1PR1/P-STAT3/VEGFA axis in triple-negative breast cancer., PMID:34059068
Targeting Immune Cell Trafficking - Insights From Research Models and Implications for Future IBD Therapy., PMID:34017333
S1PR1 signaling in cancer: A current perspective., PMID:33931142
For research use only. Not for human or drug use.
