Catalog No.
RHH38901
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG2b, kappa
Clonality
Monoclonal
Target
ICA512-TMF, ICA512-CCF, Receptor-type tyrosine-protein phosphatase-like N, Islet cell autoantigen 3, ICA512, PTPRN, Islet cell antigen 512, ICA 512, PTP IA-2, ICA3, ICA512-NTF, R-PTP-N
Concentration
0.43 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16849
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
100 mM Pro-Ac, 20 mM Arg, pH 5.0
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
clone 76F
M120 Risk Score Improves Identification of Children at High Risk of Developing Clinical Type 1 Diabetes and Reports Short-Term Response to Preventive Immunotherapy., PMID:40208750
Islet autoantibodies in Thai individuals diagnosed with type 1 diabetes before 30 years of age: a large multicentre nationwide study., PMID:39971754
First-onset type 1 diabetes in an elderly woman with multiple islet-associated autoantibodies, and a literature review., PMID:37524323
L-Asparaginase-Induced Continuous Hyperglycemia With Type 1 Diabetes-Related Antibodies and HLA Genotypes: A Case Study., PMID:36381756
Case Report: Markedly Long-Term Preservation of Pancreatic β-Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years., PMID:34899702
Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus., PMID:34205321
Research of anti-GAD and anti-IA2 autoantibodies by ELISA test in a series of Moroccan pediatric patients with diabetes type 1., PMID:33402983
Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR., PMID:33186361
Islet autoantibody profiles associated with higher diabetes risk in Lithuanian compared with English schoolchildren., PMID:32979862
Autoantibodies against zinc transporter 8 further stratify the autoantibody-defined risk for type 1 diabetes in a general population of schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes: results from the Karlsburg Type 1 Diabetes Risk Study., PMID:32799407
Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia., PMID:32705316
Masked type 1 diabetes mellitus (T1DM) unveiled by glucocorticoid replacement: a case of simultaneous development of T1DM and hypophysitis in an elderly woman., PMID:32669510
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes., PMID:32634859
A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion., PMID:32556999
Association of diabetes-related autoantibodies with the incidence of asthma, eczema and allergic rhinitis in the TRIGR randomised clinical trial., PMID:32548702
A non-coding RNASEH1 gene variant associates with type 1 diabetes and interacts with HLA tagSNPs in families from Colombia., PMID:32447804
Organ-specific autoantibodies in Chinese patients newly diagnosed with type 1 diabetes mellitus., PMID:32295990
Older age of childhood type 1 diabetes onset is associated with islet autoantibody positivity >30 years later: the Pittsburgh Epidemiology of Diabetes Complications Study., PMID:32011014
Beware Ketoacidosis with SGLT2 Inhibitors in Latent Autoimmune Diabetes of the Adult., PMID:31923401
Prevalence of anti-GAD and IA2 autoantibodies in a French cohort of patients with diabetes eligible for bariatric surgery., PMID:31874247
Low prevalence of maternal microchimerism in peripheral blood of Japanese children with type 1 diabetes., PMID:31872455
Identification of a subgroup of black South Africans with type 1 diabetes who are older at diagnosis but have lower levels of glutamic acid decarboxylase and islet antigen 2 autoantibodies., PMID:31811665
Autoimmune Diabetes Recurrence After Pancreas Transplantation: Diagnosis, Management, and Literature Review., PMID:31767825
Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot., PMID:31152768
Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood., PMID:31120497
Reference limits for GAD65 and IA-2 autoantibodies by chemiluminescence immunoassay in Northern European adults and children., PMID:30727763
Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes., PMID:30588857
Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin-requiring diabetes in China: A population-based multicentre nationwide survey., PMID:30471182
Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes., PMID:30327357
Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children., PMID:30305370
Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study., PMID:29532109
Combined checkpoint inhibitor therapy causing diabetic ketoacidosis in metastatic melanoma., PMID:29254501
Increasing ICA512 autoantibody titers predict development of abnormal oral glucose tolerance tests., PMID:28707353
Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients., PMID:28701371
Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity., PMID:28597949
Thyroid profile and autoantibodies in Type 1 diabetes subjects: A perspective from Eastern India., PMID:28217497
Inverse Relationship Between Organ-Specific Autoantibodies and Systemic Immune Mediators in Type 1 Diabetes and Type 2 Diabetes: Action LADA 11., PMID:27573939
The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2)., PMID:27329026
[Clinical characteristics of patients aged 65 and older with newly developed type 1 diabetes: An analysis of elderly patients at our hospital]., PMID:27250221
Islet cell-associated autoantibodies in Ethiopians with diabetes mellitus., PMID:27220543
Prognostic Classification Factors Associated With Development of Multiple Autoantibodies, Dysglycemia, and Type 1 Diabetes-A Recursive Partitioning Analysis., PMID:27208341
HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft., PMID:27208324
Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study., PMID:27194320
Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease., PMID:27029857
Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes., PMID:27027642
Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes., PMID:26740600
Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays., PMID:26450993
Utility of diabetes-associated autoantibodies for classification of new onset diabetes in children and adolescents., PMID:26315669
Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies., PMID:26313035
Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: Implications for determinant spreading., PMID:26071317
For research use only. Not for human or drug use.
